IMPA2 and SLC44A3

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		IMPA2	SLC44A3
Name		inositol monophosphatase 2	solute carrier family 44 member 3
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Plasma Membrane Membrane
	Molecular Function	Protein Binding Glucose-1-phosphatase Activity Inositol Monophosphate 1-phosphatase Activity Hydrolase Activity Protein Homodimerization Activity Metal Ion Binding Glycerol-2-phosphatase Activity Inositol Monophosphate 3-phosphatase Activity Inositol Monophosphate 4-phosphatase Activity Inositol Monophosphate Phosphatase Activity	Protein Binding Choline Transmembrane Transporter Activity Transmembrane Transporter Activity
	Biological Process	Inositol Metabolic Process Inositol Biosynthetic Process Phosphate-containing Compound Metabolic Process Signal Transduction Response To Lithium Ion Phosphatidylinositol Phosphate Biosynthetic Process	Phosphatidylcholine Biosynthetic Process Choline Transport Transmembrane Transport
Pathways		Synthesis of IP2, IP, and Ins in the cytosol	Synthesis of PC SLC-mediated bile acid transport
Drugs		Lithium cation Lithium citrate Lithium succinate Lithium carbonate	None
GWAS		Diabetic peripheral neuropathy in type 2 diabetes ( 31127053 ) Hemoglobin ( 32888494 ) Obsessive-compulsive disorder or autism spectrum disorder ( 28641744 ) Stroke ( 17434096 )	Computer vision syndrome ( 33941792 ) Haemorrhoidal disease ( 33888516 ) Metabolite levels (Dihydroxy docosatrienoic acid) ( 23934736 ) Myocardial infarction ( 33532862 ) Type 2 diabetes ( 22238593 )
Novel Interactors		None recorded	1 novel interactors: MIR137HG
Interacting Genes		5 interacting genes: CCT6A HERPUD1 SLC44A3 TNFRSF14 UBA3	3 interacting genes: ABHD5 FHL3 IMPA2
Entrez ID		3613	126969
HPRD ID		09329	14637
Ensembl ID		ENSG00000141401	ENSG00000143036
Uniprot IDs		O14732	B4DTF4 E9PIC5 Q8N4M1
PDB IDs		2CZH 2CZI 2CZK 2DDK 2FVZ	Not available
GO Terms Enriched among Interactors		Positive Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Adaptive Immune Memory Response Endomitotic Cell Cycle NEDD8 Activating Enzyme Activity Lewy Body Core	Glycerol-2-phosphatase Activity Glycerophospholipid Biosynthetic Process Inositol Monophosphate 4-phosphatase Activity Inositol Biosynthetic Process Inositol Monophosphate Phosphatase Activity Inositol Monophosphate 1-phosphatase Activity Glucose-1-phosphatase Activity Inositol Monophosphate 3-phosphatase Activity Negative Regulation Of Triglyceride Storage Lipase Activator Activity Phospholipid Biosynthetic Process Glycerophospholipid Metabolic Process Inositol Metabolic Process Glycerolipid Metabolic Process Positive Regulation Of Triglyceride Catabolic Process Phospholipid Metabolic Process Lysophosphatidic Acid Acyltransferase Activity Response To Lithium Ion 1-acylglycerol-3-phosphate O-acyltransferase Activity Triacylglycerol Lipase Activity Lipid Biosynthetic Process Organophosphate Biosynthetic Process Negative Regulation Of Lipid Storage Positive Regulation Of Triglyceride Metabolic Process Positive Regulation Of Lipid Catabolic Process Phosphatidic Acid Biosynthetic Process Phosphatidic Acid Metabolic Process Carboxylic Ester Hydrolase Activity Regulation Of Triglyceride Metabolic Process Regulation Of Lipid Storage Phosphatidylinositol Phosphate Biosynthetic Process Regulation Of Lipid Catabolic Process