TNFRSF14 and MASP2

		TNFRSF14	MASP2
Description		TNF receptor superfamily member 14	MBL associated serine protease 2
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane	Extracellular Region Extracellular Space Extracellular Exosome Symbiont Cell Surface
	Molecular Function	Virus Receptor Activity Tumor Necrosis Factor Receptor Activity Protein Binding Cytokine Binding Ubiquitin Protein Ligase Binding Receptor Ligand Activity	Complement Component C4b Binding Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Identical Protein Binding Metal Ion Binding Calcium-dependent Protein Binding
	Biological Process	Adaptive Immune Response Immune System Process Positive Regulation Of Cytokine Production Involved In Immune Response Immune Response Cell Surface Receptor Signaling Pathway T Cell Costimulation Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of T Cell Proliferation Innate Immune Response Negative Regulation Of Alpha-beta T Cell Proliferation Symbiont Entry Into Host Cell Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Negative Regulation Of Adaptive Immune Memory Response Positive Regulation Of T Cell Migration	Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Immune System Process Proteolysis Complement Activation Complement Activation, Classical Pathway Opsonization Zymogen Activation Killing Of Cells Of Another Organism Innate Immune Response Protein Maturation
Pathways		TNFs bind their physiological receptors Co-inhibition by BTLA Co-inhibition by BTLA
Drugs			beta-Hydroxyasparagine Narsoplimab
Diseases			Mannose-binding lectin pathway component defects, including the following two diseases: Mannose-binding lectin deficiency; Mannose-binding lectin-associated serine protease (MASP) 2 deficiency
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Autoimmune thyroid disease ( 32581359) Body mass index ( 26426971) Celiac disease ( 20190752) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 28067908) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 28445677) Primary sclerosing cholangitis ( 23603763) Rheumatoid arthritis ( 24390342 24449572 18794853 30423114) Ulcerative colitis ( 26398853 28067908 23128233 21297633)	Appendicular lean mass ( 33097823) Beard thickness ( 26926045) Body mass index ( 29273807) Eosinophil percentage of white cells ( 32888494) Male-pattern baldness ( 28196072)
Interacting Genes		30 interacting genes: A2M APP BTLA CD160 CEP126 CHD3 DGKD DRAP1 DYNLL1 ESR1 HDAC3 HDAC4 IMPA2 ITFG1 LTA MBTPS1 NDUFS2 NRIP1 RAD21 SERPINA4 TNFSF13 TNFSF14 TRAF1 TRAF2 TRAF3 TRAF5 UBQLN4 VIM WDR73 ZBTB48	4 interacting genes: C4A FCN2 MBL2 SERPING1
Entrez ID		8764	10747
HPRD ID		04122	05484
Ensembl ID		ENSG00000157873	ENSG00000009724
Uniprot IDs		B9A034 Q92956	A0A8V8TPN9 A0A8V8TQY3 O00187
PDB IDs		1JMA 2AW2 4FHQ 4RSU 5T2Q 5T2R 6NG3 7MSG	1Q3X 1SZB 1ZJK 3TVJ 5JPM
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor Receptor Binding Thioesterase Binding Identical Protein Binding CD40 Receptor Complex Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Signaling Receptor Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Biosynthetic Process Signaling Adaptor Activity Regulation Of Immune Response Regulation Of Apoptotic Process Regulation Of DNA-binding Transcription Factor Activity Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Biosynthetic Process Tumor Necrosis Factor Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Histone Deacetylase Complex Apoptotic Process Nitric-oxide Synthase Regulator Activity Programmed Cell Death Cell Death Transcription Corepressor Binding Positive Regulation Of Lymphocyte Mediated Immunity Negative Regulation Of Glial Cell Apoptotic Process CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Deacetylase Activity Histone Deacetylase Activity, Hydrolytic Mechanism Regulation Of Apoptotic Signaling Pathway Enzyme Binding Positive Regulation Of Gene Expression Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Protein Deacetylation Protein Lysine Deacetylase Activity Regulation Of Nitric Oxide Metabolic Process Regulation Of Immune System Process Regulation Of Nucleobase-containing Compound Metabolic Process Ubiquitin Protein Ligase Binding Positive Regulation Of Type II Interferon Production Immune System Process Regulation Of ATP Metabolic Process Chromatin Binding Positive Regulation Of Metabolic Process Negative Regulation Of Myotube Differentiation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity	Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Opsonization Symbiont Cell Surface Complement Activation Regulation Of Immune Response Positive Regulation Of Phagocytosis Regulation Of Phagocytosis Positive Regulation Of Opsonization Blood Microparticle Killing Of Cells Of Another Organism Regulation Of Opsonization Defense Response To Gram-positive Bacterium Serine-type Endopeptidase Complex Regulation Of Immune System Process Positive Regulation Of Endocytosis Innate Immune Response Cell Killing Defense Response To Symbiont Defense Response To Other Organism Humoral Immune Response Antigen Binding Positive Regulation Of Immune Effector Process Complement Activation, Classical Pathway Zymogen Activation Pattern Recognition Receptor Activity Defense Response To Bacterium Protein Maturation Positive Regulation Of Immune System Process Regulation Of Endocytosis Response To Other Organism External Side Of Plasma Membrane Cell Surface Pattern Recognition Receptor Signaling Pathway Immune Response Immune Effector Process Response To Bacterium Activation Of Immune Response Response To External Biotic Stimulus Regulation Of Innate Immune Response Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Defense Response Collagen Trimer Calcium-dependent Protein Binding Extracellular Space Defense Response To Gram-negative Bacterium Mannan Binding Regulation Of Vesicle-mediated Transport Negative Regulation Of Complement Activation, Lectin Pathway Positive Regulation Of Immune Response Lipoteichoic Acid Immune Receptor Activity
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