TNFRSF14 and NID2

Data Source: HiPPIP (Novel)

		TNFRSF14	NID2
Name		TNF receptor superfamily member 14	nidogen 2
Structure			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane	Extracellular Region Basement Membrane Extracellular Space Plasma Membrane Extracellular Matrix Extracellular Exosome
	Molecular Function	Virus Receptor Activity Tumor Necrosis Factor Receptor Activity Protein Binding Cytokine Binding Ubiquitin Protein Ligase Binding Receptor Ligand Activity	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Collagen Binding
	Biological Process	Adaptive Immune Response Immune System Process Positive Regulation Of Cytokine Production Involved In Immune Response Immune Response Cell Surface Receptor Signaling Pathway T Cell Costimulation Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of T Cell Proliferation Innate Immune Response Negative Regulation Of Alpha-beta T Cell Proliferation Symbiont Entry Into Host Cell Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Negative Regulation Of Adaptive Immune Memory Response Positive Regulation Of T Cell Migration	Cell Adhesion Cell-matrix Adhesion Basement Membrane Organization
Pathways		TNFs bind their physiological receptors Co-inhibition by BTLA Co-inhibition by BTLA	Laminin interactions Laminin interactions
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Autoimmune thyroid disease ( 32581359 ) Body mass index ( 26426971 ) Celiac disease ( 20190752 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Inflammatory bowel disease ( 28067908 ) Medication use (thyroid preparations) ( 31015401 ) Multiple sclerosis ( 28445677 ) Primary sclerosing cholangitis ( 23603763 ) Rheumatoid arthritis ( 24390342 24449572 18794853 30423114 ) Ulcerative colitis ( 26398853 28067908 23128233 21297633 )	Age-related hearing impairment ( 34108613 ) Apolipoprotein A1 levels ( 32203549 ) Body mass index ( 28892062 ) Craniofacial microsomia ( 26853712 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) HDL cholesterol levels ( 32203549 ) Hip index ( 34021172 ) Lung cancer (smoking interaction) ( 24658283 ) Pulmonary function ( 17903307 ) Triglyceride levels ( 32203549 29403010 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) Waist-to-hip ratio adjusted for body mass index ( 26785701 ) White matter hyperintensity volume ( 33293549 ) White matter hyperintensity volume (adjusted for hypertension) ( 33293549 ) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549 )
Novel Interactors		9 novel interactors: ANGPTL7 ENO1 MASP2 NDST2 NID2 POLR1A RPL22 SRM UNC93A	3 novel interactors: KCNJ1 POLE2 TNFRSF14
Interacting Genes		30 interacting genes: A2M APP BTLA CD160 CEP126 CHD3 DGKD DRAP1 DYNLL1 ESR1 HDAC3 HDAC4 IMPA2 ITFG1 LTA MBTPS1 NDUFS2 NRIP1 RAD21 SERPINA4 TNFSF13 TNFSF14 TRAF1 TRAF2 TRAF3 TRAF5 UBQLN4 VIM WDR73 ZBTB48	24 interacting genes: ANKRD13D CCN3 COL13A1 COL1A1 COL4A1 ELN GNE HOXC8 HSPG2 KPRP KRTAP1-3 KRTAP10-3 KRTAP6-2 LAMC1 LCE1A MAML3 PITX1 PLSCR4 RBP3 SKIL TFG UNKL ZNF581 ZNF774
Entrez ID		8764	22795
HPRD ID		04122	05654
Ensembl ID		ENSG00000157873	ENSG00000087303
Uniprot IDs		B9A034 Q92956	Q14112
PDB IDs		1JMA 2AW2 4FHQ 4RSU 5T2Q 5T2R 6NG3 7MSG	Not available
GO Terms Enriched among Interactors		Tumor Necrosis Factor Receptor Binding Thioesterase Binding Identical Protein Binding CD40 Receptor Complex Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Signaling Receptor Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Biosynthetic Process Signaling Adaptor Activity Regulation Of Immune Response Regulation Of Apoptotic Process Regulation Of DNA-binding Transcription Factor Activity Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Biosynthetic Process Tumor Necrosis Factor Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Histone Deacetylase Complex Apoptotic Process Nitric-oxide Synthase Regulator Activity Programmed Cell Death Cell Death Transcription Corepressor Binding Positive Regulation Of Lymphocyte Mediated Immunity Negative Regulation Of Glial Cell Apoptotic Process CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Deacetylase Activity Histone Deacetylase Activity, Hydrolytic Mechanism Regulation Of Apoptotic Signaling Pathway Enzyme Binding Positive Regulation Of Gene Expression Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Protein Deacetylation Protein Lysine Deacetylase Activity Regulation Of Nitric Oxide Metabolic Process Regulation Of Immune System Process Regulation Of Nucleobase-containing Compound Metabolic Process Ubiquitin Protein Ligase Binding Positive Regulation Of Type II Interferon Production Immune System Process Regulation Of ATP Metabolic Process Chromatin Binding Positive Regulation Of Metabolic Process Negative Regulation Of Myotube Differentiation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity	Extracellular Matrix Basement Membrane Extracellular Matrix Structural Constituent Conferring Tensile Strength Extracellular Matrix Structural Constituent Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Tissue Development Platelet-derived Growth Factor Binding Extracellular Matrix Constituent Conferring Elasticity Skeletal Muscle Tissue Development Collagen Trimer Collagen-activated Signaling Pathway Extracellular Matrix Organization Extracellular Structure Organization Circulatory System Development