IMPA2 and UBA3

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		IMPA2	UBA3
Gene Name		inositol(myo)-1(or 4)-monophosphatase 2	ubiquitin-like modifier activating enzyme 3
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Cytosol
	Molecular Function	Inositol Monophosphate 1-phosphatase Activity Protein Homodimerization Activity Metal Ion Binding Inositol Monophosphate 3-phosphatase Activity Inositol Monophosphate 4-phosphatase Activity	Protein Binding ATP Binding Acid-amino Acid Ligase Activity NEDD8 Activating Enzyme Activity Protein Heterodimerization Activity
	Biological Process	Inositol Biosynthetic Process Phosphate-containing Compound Metabolic Process Signal Transduction Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Phosphatidylinositol Phosphorylation Inositol Phosphate Dephosphorylation	Cellular Protein Modification Process Proteolysis Endomitotic Cell Cycle Protein Neddylation Regulation Of Cell Cycle
Pathways		Synthesis of IP2, IP, and Ins in the cytosol Inositol phosphate metabolism	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs		Lithium
Diseases
GWAS		Stroke ( 17434096)
Protein-Protein Interactions		4 interactors: HERPUD1 IMPA1 TNFRSF14 UBA3	9 interactors: CHD3 CPNE2 IMPA2 KDM1A NAE1 NEDD8 UBC UBE2F UBE2M
Entrez ID		3613	9039
HPRD ID		09329	04413
Ensembl ID		ENSG00000141401	ENSG00000144744
Uniprot IDs		O14732	B7Z5F6 Q8TBC4
PDB IDs		2CZH 2CZI 2CZK 2DDK 2FVZ	1R4M 1R4N 1TT5 1Y8X 1YOV 2LQ7 2NVU 3DBH 3DBL 3DBR 3FN1 3GZN
Enriched GO Terms of Interacting Partners?		Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Endomitotic Cell Cycle Positive Regulation Of Cytokine Secretion Involved In Immune Response	Protein Neddylation Protein Modification By Small Protein Conjugation Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Protein Modification Process Regulation Of Primitive Erythrocyte Differentiation Mitotic DNA Integrity Checkpoint Cellular Response To Growth Factor Stimulus Cellular Protein Metabolic Process Regulation Of Apoptotic Process Response To Growth Factor Regulation Of Cell Death Negative Regulation Of Mitotic Cell Cycle Phase Transition Carbohydrate Biosynthetic Process Cellular Metabolic Process Mitotic Cell Cycle Checkpoint Mitotic DNA Replication Checkpoint Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Histone H3-K4 Methylation Histone H3-K9 Demethylation Histone H3-K4 Demethylation Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Cellular Carbohydrate Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Neuron Apoptotic Process Inositol Biosynthetic Process Protein Metabolic Process Positive Regulation Of Megakaryocyte Differentiation DNA Replication Checkpoint Viral Protein Processing Cell Cycle Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Inositol Phosphate Dephosphorylation Positive Regulation Of Hormone Biosynthetic Process Regulation Of Neuron Death Negative Regulation Of Histone H3-K9 Methylation Phosphorylated Carbohydrate Dephosphorylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Granulocyte Differentiation Regulation Of Megakaryocyte Differentiation
Tagcloud ?		accomplices counterbalance dao daoa dictate dpysl2 dtnbp1 famine grin1 grin2b grm3 grm4 hypomyelination il1b il1rn metabotropic ncam1 nd4 ndufv2 nos1 nos1ap nurture oligodendrocyte pdlim5 pik3c3 pip5k2a reconcile rgs4 ywhah	activase activases conjugases developmentally discreet dysregulated e1 e3 homeostatic k48 k63 ligases mount nedd nedd8ylation pias3 polyubiquitination postmortem rnf7 schizophrenia sinai stg sumoylation ubiquitination ubl ufl1 ufmylation underlies
Tagcloud (Difference) ?		accomplices counterbalance dao daoa dictate dpysl2 dtnbp1 famine grin1 grin2b grm3 grm4 hypomyelination il1b il1rn metabotropic ncam1 nd4 ndufv2 nos1 nos1ap nurture oligodendrocyte pdlim5 pik3c3 pip5k2a reconcile rgs4 ywhah	activase activases conjugases developmentally discreet dysregulated e1 e3 homeostatic k48 k63 ligases mount nedd nedd8ylation pias3 polyubiquitination postmortem rnf7 schizophrenia sinai stg sumoylation ubiquitination ubl ufl1 ufmylation underlies
Tagcloud (Intersection) ?