TNFRSF14 and NDST2

		TNFRSF14	NDST2
Description		TNF receptor superfamily member 14	N-deacetylase and N-sulfotransferase 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane	Golgi Membrane Golgi Apparatus Membrane
	Molecular Function	Virus Receptor Activity Tumor Necrosis Factor Receptor Activity Protein Binding Cytokine Binding Ubiquitin Protein Ligase Binding Receptor Ligand Activity	Catalytic Activity Sulfotransferase Activity Heparan Sulfate N-sulfotransferase Activity Transferase Activity Hydrolase Activity Deacetylase Activity N-acetylglucosamine Deacetylase Activity Heparan Sulfate N-deacetylase Activity
	Biological Process	Adaptive Immune Response Immune System Process Positive Regulation Of Cytokine Production Involved In Immune Response Immune Response Cell Surface Receptor Signaling Pathway T Cell Costimulation Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of T Cell Proliferation Innate Immune Response Negative Regulation Of Alpha-beta T Cell Proliferation Symbiont Entry Into Host Cell Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Negative Regulation Of Adaptive Immune Memory Response Positive Regulation Of T Cell Migration	Regulation Of Angiotensin Levels In Blood Mast Cell Mediated Immunity Heparan Sulfate Proteoglycan Biosynthetic Process Heparin Proteoglycan Biosynthetic Process
Pathways		TNFs bind their physiological receptors Co-inhibition by BTLA Co-inhibition by BTLA	HS-GAG biosynthesis
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Autoimmune thyroid disease ( 32581359) Body mass index ( 26426971) Celiac disease ( 20190752) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 28067908) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 28445677) Primary sclerosing cholangitis ( 23603763) Rheumatoid arthritis ( 24390342 24449572 18794853 30423114) Ulcerative colitis ( 26398853 28067908 23128233 21297633)	Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Crohn's disease ( 28067908)
Interacting Genes		30 interacting genes: A2M APP BTLA CD160 CEP126 CHD3 DGKD DRAP1 DYNLL1 ESR1 HDAC3 HDAC4 IMPA2 ITFG1 LTA MBTPS1 NDUFS2 NRIP1 RAD21 SERPINA4 TNFSF13 TNFSF14 TRAF1 TRAF2 TRAF3 TRAF5 UBQLN4 VIM WDR73 ZBTB48
Entrez ID		8764	8509
HPRD ID		04122	04465
Ensembl ID		ENSG00000157873	ENSG00000166507
Uniprot IDs		B9A034 Q92956	B4E139 P52849 S4R438
PDB IDs		1JMA 2AW2 4FHQ 4RSU 5T2Q 5T2R 6NG3 7MSG
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor Receptor Binding Thioesterase Binding Identical Protein Binding CD40 Receptor Complex Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Signaling Receptor Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Biosynthetic Process Signaling Adaptor Activity Regulation Of Immune Response Regulation Of Apoptotic Process Regulation Of DNA-binding Transcription Factor Activity Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Biosynthetic Process Tumor Necrosis Factor Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Histone Deacetylase Complex Apoptotic Process Nitric-oxide Synthase Regulator Activity Programmed Cell Death Cell Death Transcription Corepressor Binding Positive Regulation Of Lymphocyte Mediated Immunity Negative Regulation Of Glial Cell Apoptotic Process CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Deacetylase Activity Histone Deacetylase Activity, Hydrolytic Mechanism Regulation Of Apoptotic Signaling Pathway Enzyme Binding Positive Regulation Of Gene Expression Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Protein Deacetylation Protein Lysine Deacetylase Activity Regulation Of Nitric Oxide Metabolic Process Regulation Of Immune System Process Regulation Of Nucleobase-containing Compound Metabolic Process Ubiquitin Protein Ligase Binding Positive Regulation Of Type II Interferon Production Immune System Process Regulation Of ATP Metabolic Process Chromatin Binding Positive Regulation Of Metabolic Process Negative Regulation Of Myotube Differentiation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity	Negative Regulation Of Adaptive Immune Memory Response Tumor Necrosis Factor Receptor Activity Negative Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of T Cell Migration Positive Regulation Of Lymphocyte Migration T Cell Costimulation Regulation Of T Cell Migration Cytokine Binding Negative Regulation Of Alpha-beta T Cell Activation Negative Regulation Of T Cell Proliferation Positive Regulation Of Mononuclear Cell Migration Negative Regulation Of Leukocyte Proliferation Negative Regulation Of Lymphocyte Proliferation Regulation Of Lymphocyte Migration Positive Regulation Of Cytokine Production Involved In Immune Response Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Mononuclear Cell Proliferation Defense Response To Gram-negative Bacterium Virus Receptor Activity Negative Regulation Of Adaptive Immune Response Defense Response To Gram-positive Bacterium Receptor Ligand Activity Regulation Of Alpha-beta T Cell Activation Regulation Of Cytokine Production Involved In Immune Response Symbiont Entry Into Host Cell Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Negative Regulation Of T Cell Activation Negative Regulation Of Leukocyte Cell-cell Adhesion Biological Process Involved In Interaction With Host Negative Regulation Of Lymphocyte Activation Regulation Of Production Of Molecular Mediator Of Immune Response Regulation Of T Cell Proliferation Negative Regulation Of Leukocyte Activation Regulation Of Leukocyte Migration Negative Regulation Of Immune Response Negative Regulation Of Cell Activation Negative Regulation Of Cell-cell Adhesion Regulation Of Adaptive Immune Response Regulation Of Mononuclear Cell Proliferation Positive Regulation Of T Cell Activation Positive Regulation Of Immune Effector Process Regulation Of Leukocyte Proliferation Positive Regulation Of Leukocyte Cell-cell Adhesion Adaptive Immune Response Defense Response To Bacterium Ubiquitin Protein Ligase Binding Negative Regulation Of Cell Adhesion Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion
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