TNFRSF14 and SERPINA4

Number of citations: 0 (PubMedID 21900206)
Data Source: BioGRID (two hybrid)

		TNFRSF14	SERPINA4
Name		TNF receptor superfamily member 14	serpin family A member 4
Structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane	Extracellular Region Extracellular Space Platelet Dense Granule Lumen Extracellular Exosome
	Molecular Function	Virus Receptor Activity Tumor Necrosis Factor Receptor Activity Protein Binding Cytokine Binding Ubiquitin Protein Ligase Binding Receptor Ligand Activity	Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity
	Biological Process	Adaptive Immune Response Immune System Process Positive Regulation Of Cytokine Production Involved In Immune Response Immune Response Cell Surface Receptor Signaling Pathway T Cell Costimulation Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of T Cell Proliferation Innate Immune Response Negative Regulation Of Alpha-beta T Cell Proliferation Symbiont Entry Into Host Cell Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Negative Regulation Of Adaptive Immune Memory Response Positive Regulation Of T Cell Migration	None
Pathways		TNFs bind their physiological receptors Co-inhibition by BTLA Co-inhibition by BTLA	Platelet degranulation Developmental Lineage of Pancreatic Acinar Cells
Drugs		None	Zinc Copper Zinc acetate
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Autoimmune thyroid disease ( 32581359 ) Body mass index ( 26426971 ) Celiac disease ( 20190752 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Inflammatory bowel disease ( 28067908 ) Medication use (thyroid preparations) ( 31015401 ) Multiple sclerosis ( 28445677 ) Primary sclerosing cholangitis ( 23603763 ) Rheumatoid arthritis ( 24390342 24449572 18794853 30423114 ) Ulcerative colitis ( 26398853 28067908 23128233 21297633 )	Blood protein levels ( 30072576 ) Vaspin levels ( 22907691 )
Novel Interactors		9 novel interactors: ANGPTL7 ENO1 MASP2 NDST2 NID2 POLR1A RPL22 SRM UNC93A	1 novel interactors: TRIP11
Interacting Genes		30 interacting genes: A2M APP BTLA CD160 CEP126 CHD3 DGKD DRAP1 DYNLL1 ESR1 HDAC3 HDAC4 IMPA2 ITFG1 LTA MBTPS1 NDUFS2 NRIP1 RAD21 SERPINA4 TNFSF13 TNFSF14 TRAF1 TRAF2 TRAF3 TRAF5 UBQLN4 VIM WDR73 ZBTB48	14 interacting genes: CFTR CTSD GADD45G ILK KLK1 KLK2 MAP4K2 MAPK6 NR4A1 RASA1 TAB1 TNFRSF14 TNNT1 YAE1
Entrez ID		8764	5267
HPRD ID		04122	01004
Ensembl ID		ENSG00000157873	ENSG00000100665
Uniprot IDs		B9A034 Q92956	A0A024R6I9 P29622
PDB IDs		1JMA 2AW2 4FHQ 4RSU 5T2Q 5T2R 6NG3 7MSG	6F02
GO Terms Enriched among Interactors		Tumor Necrosis Factor Receptor Binding Thioesterase Binding Identical Protein Binding CD40 Receptor Complex Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Signaling Receptor Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Biosynthetic Process Signaling Adaptor Activity Regulation Of Immune Response Regulation Of Apoptotic Process Regulation Of DNA-binding Transcription Factor Activity Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Biosynthetic Process Tumor Necrosis Factor Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Histone Deacetylase Complex Apoptotic Process Nitric-oxide Synthase Regulator Activity Programmed Cell Death Cell Death Transcription Corepressor Binding Positive Regulation Of Lymphocyte Mediated Immunity Negative Regulation Of Glial Cell Apoptotic Process CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Deacetylase Activity Histone Deacetylase Activity, Hydrolytic Mechanism Regulation Of Apoptotic Signaling Pathway Enzyme Binding Positive Regulation Of Gene Expression Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Protein Deacetylation Protein Lysine Deacetylase Activity Regulation Of Nitric Oxide Metabolic Process Regulation Of Immune System Process Regulation Of Nucleobase-containing Compound Metabolic Process Ubiquitin Protein Ligase Binding Positive Regulation Of Type II Interferon Production Immune System Process Regulation Of ATP Metabolic Process Chromatin Binding Positive Regulation Of Metabolic Process Negative Regulation Of Myotube Differentiation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity	None