ZNRD1 and CIC

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ZNRD1	CIC
Gene Name		zinc ribbon domain containing 1	capicua transcriptional repressor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm DNA-directed RNA Polymerase I Complex	Nucleus
	Molecular Function	RNA Polymerase I Activity Nucleic Acid Binding Zinc Ion Binding	DNA Binding Chromatin Binding Protein Binding
	Biological Process	Nucleobase-containing Compound Metabolic Process Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Gene Expression Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Lung Alveolus Development
Pathways		NoRC negatively regulates rRNA expression RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription RNA Polymerase I Transcription Termination RNA Polymerase I Promoter Escape RNA Polymerase I Promoter Clearance Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression
Drugs
Diseases
GWAS		AIDS progression ( 19115949) HIV-1 control ( 20041166)
Protein-Protein Interactions		15 interactors: APOA1 ATXN2 CIC DUSP1 FHL3 GFI1B GPR20 HAX1 IL15 IVNS1ABP NONO SACS SERPINA3 UBE2I ZNF593	13 interactors: ATXN1 CENPJ CSNK2B GABPB1 GTPBP3 NFYC PICK1 PLK1 PYCR2 SEC62 SETD2 TRIM22 ZNRD1
Entrez ID		30834	23152
HPRD ID		09601	10831
Ensembl ID		ENSG00000066379	ENSG00000079432
Uniprot IDs		Q2L6J2 Q9P1U0	Q96RK0
PDB IDs			4J2J 4J2L
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Intracellular Signal Transduction Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cellular Process Extrathymic T Cell Selection Negative Regulation Of Cell Adhesion Molecule Production Positive Regulation Of SUMO Transferase Activity Regulation Of Signal Transduction Negative Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Interleukin-1 Beta Secretion Regulation Of Signaling Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Cholesterol Import NK T Cell Proliferation Negative Regulation Of Intracellular Signal Transduction Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Interleukin-1 Secretion Alpha-beta T Cell Proliferation Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Ketone Metabolic Process Regulation Of Protein Phosphorylation Skeletal Muscle Atrophy High-density Lipoprotein Particle Clearance Negative Regulation Of Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Natural Killer Cell Proliferation Striated Muscle Atrophy Protein Oxidation Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Gene Expression Regulation Of Natural Killer Cell Proliferation Muscle Atrophy Negative Regulation Of Cytokine Secretion Involved In Immune Response Negative Regulation Of Heterotypic Cell-cell Adhesion High-density Lipoprotein Particle Assembly Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Signaling Regulation Of Cellular Component Organization Negative Regulation Of Oxidative Stress-induced Neuron Death Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway	Heterocycle Metabolic Process Nitrogen Compound Metabolic Process Histone H3-K36 Trimethylation RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process DNA-templated Transcription, Elongation Activation Of APC-Cdc20 Complex Activity Cellular Aromatic Compound Metabolic Process Centrosome Organization Positive Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Cell Migration Involved In Vasculogenesis Microtubule Organizing Center Organization Cellular Nitrogen Compound Metabolic Process G2/M Transition Of Mitotic Cell Cycle Polar Body Extrusion After Meiotic Divisions Cellular Metabolic Process Activation Of Anaphase-promoting Complex Activity Meiotic Cytokinesis L-proline Biosynthetic Process Posttranslational Protein Targeting To Membrane Positive Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Activin Receptor Signaling Pathway DNA Methylation Involved In Embryo Development Adiponectin-activated Signaling Pathway Regulation Of MRNA Export From Nucleus Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Metaphase/anaphase Transition Of Mitotic Cell Cycle Histone H3-K36 Methylation Dendritic Spine Maintenance Regulation Of Metabolic Process Regulation Of Gene Expression, Epigenetic Positive Regulation Of Metabolic Process Tube Development Coronary Vasculature Morphogenesis Endothelial Tube Morphogenesis Gene Expression Regulation Of Centriole Replication Protein Localization To Chromatin Neuronal Ion Channel Clustering Mitotic Cell Cycle Regulation Of RNA Export From Nucleus Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Tagcloud ?		acceleration angiogenesis arrest block cdk2 cdk4 cip1 controlling cytostatic densities dephosphorylation differentially fragmentary gastric instability kip1 microarray microvessel mkn28 p27 pivotal prb precise ribbon sense skp2 suppressed waf1 zinc	aetiology assumed bacteriuria catheterization clean complaints distress epq evaluations eysenck ghq intermittent inventory neurogenic neurotic neuroticism personality practised prescription psychometric spielberger stai thirds tolerability trait undergone unnecessary verify x1
Tagcloud (Difference) ?		acceleration angiogenesis arrest block cdk2 cdk4 cip1 controlling cytostatic densities dephosphorylation differentially fragmentary gastric instability kip1 microarray microvessel mkn28 p27 pivotal prb precise ribbon sense skp2 suppressed waf1 zinc	aetiology assumed bacteriuria catheterization clean complaints distress epq evaluations eysenck ghq intermittent inventory neurogenic neurotic neuroticism personality practised prescription psychometric spielberger stai thirds tolerability trait undergone unnecessary verify x1
Tagcloud (Intersection) ?