ZNRD1 and ZNF593

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		ZNRD1	ZNF593
Gene Name		zinc ribbon domain containing 1	zinc finger protein 593
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm DNA-directed RNA Polymerase I Complex	Nucleus Nucleolus
	Molecular Function	RNA Polymerase I Activity Nucleic Acid Binding Zinc Ion Binding	DNA Binding Transcription Corepressor Activity Metal Ion Binding
	Biological Process	Nucleobase-containing Compound Metabolic Process Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Gene Expression Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated
Pathways		NoRC negatively regulates rRNA expression RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription RNA Polymerase I Transcription Termination RNA Polymerase I Promoter Escape RNA Polymerase I Promoter Clearance Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression
Drugs
Diseases
GWAS		AIDS progression ( 19115949) HIV-1 control ( 20041166)
Protein-Protein Interactions		15 interactors: APOA1 ATXN2 CIC DUSP1 FHL3 GFI1B GPR20 HAX1 IL15 IVNS1ABP NONO SACS SERPINA3 UBE2I ZNF593	7 interactors: GPR3 LNX1 MAP3K7 MAPK8IP2 RAB1A ZAK ZNRD1
Entrez ID		30834	51042
HPRD ID		09601	15866
Ensembl ID		ENSG00000066379
Uniprot IDs		Q2L6J2 Q9P1U0	O00488
PDB IDs			1ZR9
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Intracellular Signal Transduction Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cellular Process Extrathymic T Cell Selection Negative Regulation Of Cell Adhesion Molecule Production Positive Regulation Of SUMO Transferase Activity Regulation Of Signal Transduction Negative Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Interleukin-1 Beta Secretion Regulation Of Signaling Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Cholesterol Import NK T Cell Proliferation Negative Regulation Of Intracellular Signal Transduction Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Interleukin-1 Secretion Alpha-beta T Cell Proliferation Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Ketone Metabolic Process Regulation Of Protein Phosphorylation Skeletal Muscle Atrophy High-density Lipoprotein Particle Clearance Negative Regulation Of Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Natural Killer Cell Proliferation Striated Muscle Atrophy Protein Oxidation Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Gene Expression Regulation Of Natural Killer Cell Proliferation Muscle Atrophy Negative Regulation Of Cytokine Secretion Involved In Immune Response Negative Regulation Of Heterotypic Cell-cell Adhesion High-density Lipoprotein Particle Assembly Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Signaling Regulation Of Cellular Component Organization Negative Regulation Of Oxidative Stress-induced Neuron Death Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway	JNK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade MAPK Cascade Signal Transduction By Phosphorylation Activation Of MAPKK Activity Positive Regulation Of JUN Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Regulation Of JUN Kinase Activity Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Kinase Activity Positive Regulation Of Transferase Activity Regulation Of Phosphorus Metabolic Process Cellular Response To Stress Positive Regulation Of JNK Cascade Regulation Of MAPK Cascade Interleukin-8 Secretion Cargo Loading Into COPII-coated Vesicle Activation Of MAPK Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of Metabolic Process Intracellular Signal Transduction Interleukin-8 Production Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Nonassociative Learning Positive Regulation Of Phosphorylation Positive Regulation Of MAP Kinase Activity Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Positive Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process Cargo Loading Into Vesicle Protein Complex Assembly Activation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Growth Hormone Secretion Cellular Protein Complex Assembly Signal Complex Assembly Positive Regulation Of Signal Transduction I-kappaB Phosphorylation
Tagcloud ?		acceleration angiogenesis arrest block cdk2 cdk4 cip1 controlling cytostatic densities dephosphorylation differentially fragmentary gastric instability kip1 microarray microvessel mkn28 p27 pivotal prb precise ribbon sense skp2 suppressed waf1 zinc
Tagcloud (Difference) ?		acceleration angiogenesis arrest block cdk2 cdk4 cip1 controlling cytostatic densities dephosphorylation differentially fragmentary gastric instability kip1 microarray microvessel mkn28 p27 pivotal prb precise ribbon sense skp2 suppressed waf1 zinc
Tagcloud (Intersection) ?