POLR1H and SACS

Number of citations of the paper that reports this interaction (PubMedID 16713569)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		POLR1H	SACS
Description		RNA polymerase I subunit H	sacsin molecular chaperone
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GO Annotations	Cellular Component	DNA-directed RNA Polymerase Complex Nucleus Nucleoplasm Nucleolus RNA Polymerase I Complex	Nucleus Cytoplasm Mitochondrion Axon Dendrite Cell Body Fiber
	Molecular Function	Nucleic Acid Binding DNA-directed RNA Polymerase Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Hsp70 Protein Binding Identical Protein Binding Low-density Lipoprotein Particle Receptor Binding Protein-folding Chaperone Binding Proteasome Binding
	Biological Process	Nucleobase-containing Compound Metabolic Process DNA-templated Transcription Termination Of RNA Polymerase I Transcription	Protein Folding Negative Regulation Of Inclusion Body Assembly
Pathways		NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
Drugs
Diseases
GWAS			Blood pressure (smoking interaction) ( 25189868) Hypothyroidism ( 22493691) Metabolite levels ( 23823483) Protein quantitative trait loci ( 18464913) Type 2 diabetes ( 23300278)
Interacting Genes		18 interacting genes: APOA1 ATXN2 CIC DUSP1 FHL3 GFI1B GPR20 HAX1 IL15 IVNS1ABP MAPK8IP2 NONO SACS SERPINA3 TNS2 TRIML2 UBE2I ZNF593	7 interacting genes: ACTN4 ADRB2 DSCAM PICK1 POLR1H TSC22D4 UBE3A
Entrez ID		30834	26278
HPRD ID		09601	05135
Ensembl ID		ENSG00000066379	ENSG00000151835
Uniprot IDs		Q2L6J2 Q9P1U0	A0A804HIQ1 Q9NZJ4
PDB IDs		7OB9 7OBA 7OBB 7VBA 7VBB 7VBC 8A43	1IUR 3O10 5V44 5V45 5V46 5VSX 5VSZ
Enriched GO Terms of Interacting Partners?			Nucleoside Binding Positive Regulation Of Sodium:proton Antiporter Activity Nuclear Receptor-mediated Signaling Pathway Regulation Of Sodium Ion Transport Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Beta2-adrenergic Receptor Activity Modulation Of Chemical Synaptic Transmission Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Sperm Entry Regulation Of Golgi Lumen Acidification Positive Regulation Of Golgi Lumen Acidification Termination Of RNA Polymerase I Transcription
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