ZNRD1 and IL15

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ZNRD1	IL15
Gene Name		zinc ribbon domain containing 1	interleukin 15
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm DNA-directed RNA Polymerase I Complex	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Endosome Golgi Apparatus Integral Component Of Plasma Membrane Cell Surface Membrane
	Molecular Function	RNA Polymerase I Activity Nucleic Acid Binding Zinc Ion Binding	Cytokine Activity Cytokine Receptor Binding Protein Binding
	Biological Process	Nucleobase-containing Compound Metabolic Process Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Gene Expression Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic	Natural Killer Cell Differentiation NK T Cell Proliferation Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Aging Positive Regulation Of Cell Proliferation Skeletal Muscle Atrophy Hyaluronan Metabolic Process Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Natural Killer Cell Differentiation Positive Regulation Of Tissue Remodeling Positive Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Extrathymic T Cell Selection Regulation Of T Cell Differentiation Cell Maturation Lymph Node Development Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Defense Response To Virus By Host Positive Regulation Of Inflammatory Response Positive Regulation Of Immune Response Cellular Response To Vitamin D
Pathways		NoRC negatively regulates rRNA expression RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription RNA Polymerase I Transcription Termination RNA Polymerase I Promoter Escape RNA Polymerase I Promoter Clearance Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression
Drugs
Diseases
GWAS		AIDS progression ( 19115949) HIV-1 control ( 20041166)	Response to treatment for acute lymphoblastic leukemia ( 19176441)
Protein-Protein Interactions		15 interactors: APOA1 ATXN2 CIC DUSP1 FHL3 GFI1B GPR20 HAX1 IL15 IVNS1ABP NONO SACS SERPINA3 UBE2I ZNF593	7 interactors: APP IL15RA IL2RB IL2RG STAT5B TRAF3 ZNRD1
Entrez ID		30834	3600
HPRD ID		09601	02776
Ensembl ID		ENSG00000066379	ENSG00000164136
Uniprot IDs		Q2L6J2 Q9P1U0	P40933 Q6FGX7
PDB IDs			2XQB 2Z3Q 2Z3R 4GS7
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Intracellular Signal Transduction Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cellular Process Extrathymic T Cell Selection Negative Regulation Of Cell Adhesion Molecule Production Positive Regulation Of SUMO Transferase Activity Regulation Of Signal Transduction Negative Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Interleukin-1 Beta Secretion Regulation Of Signaling Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Cholesterol Import NK T Cell Proliferation Negative Regulation Of Intracellular Signal Transduction Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Interleukin-1 Secretion Alpha-beta T Cell Proliferation Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Ketone Metabolic Process Regulation Of Protein Phosphorylation Skeletal Muscle Atrophy High-density Lipoprotein Particle Clearance Negative Regulation Of Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Natural Killer Cell Proliferation Striated Muscle Atrophy Protein Oxidation Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Gene Expression Regulation Of Natural Killer Cell Proliferation Muscle Atrophy Negative Regulation Of Cytokine Secretion Involved In Immune Response Negative Regulation Of Heterotypic Cell-cell Adhesion High-density Lipoprotein Particle Assembly Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Signaling Regulation Of Cellular Component Organization Negative Regulation Of Oxidative Stress-induced Neuron Death Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway	Response To Interleukin-2 Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Interleukin-2-mediated Signaling Pathway Response To Cytokine Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Response To Interleukin-4 Response To Organic Substance Regulation Of Multicellular Organism Growth Positive Regulation Of Mitotic Cell Cycle Interleukin-7-mediated Signaling Pathway Synaptic Growth At Neuromuscular Junction Signal Transduction Collateral Sprouting In Absence Of Injury Signaling Cell Communication Creatinine Metabolic Process Development Of Secondary Male Sexual Characteristics Positive Regulation Of Innate Immune Response Collateral Sprouting Axon Midline Choice Point Recognition Isoleucine Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Allantoin Metabolic Process Positive Regulation Of Natural Killer Cell Proliferation Immune System Process Taurine Metabolic Process Axon Choice Point Recognition Regulation Of Natural Killer Cell Proliferation Regulation Of Innate Immune Response Prolactin Signaling Pathway Response To Interleukin-15 Steroid Metabolic Process Positive Regulation Of Gamma-delta T Cell Differentiation Cellular Response To Stimulus Negative Regulation Of Erythrocyte Differentiation Valine Metabolic Process Neuron Remodeling Creatine Metabolic Process Positive Regulation Of Cell Cycle Positive Regulation Of Gamma-delta T Cell Activation Succinate Metabolic Process Development Of Secondary Female Sexual Characteristics Regulation Of Developmental Growth Toll Signaling Pathway Positive Regulation Of Natural Killer Cell Differentiation Interleukin-4-mediated Signaling Pathway Regulation Of Gamma-delta T Cell Differentiation Development Of Secondary Sexual Characteristics
Tagcloud ?		acceleration angiogenesis arrest block cdk2 cdk4 cip1 controlling cytostatic densities dephosphorylation differentially fragmentary gastric instability kip1 microarray microvessel mkn28 p27 pivotal prb precise ribbon sense skp2 suppressed waf1 zinc	125a 7e 99b arthritis clusters conversion depletion exacerbated immunomodulatory inappropriate involve let micrornas mirna mirnas monocyte monocytes monocytic osteoclast p65 promoters proper rheumatoid shutting tnfaip3 upregulates upregulating upregulation whereby
Tagcloud (Difference) ?		acceleration angiogenesis arrest block cdk2 cdk4 cip1 controlling cytostatic densities dephosphorylation differentially fragmentary gastric instability kip1 microarray microvessel mkn28 p27 pivotal prb precise ribbon sense skp2 suppressed waf1 zinc	125a 7e 99b arthritis clusters conversion depletion exacerbated immunomodulatory inappropriate involve let micrornas mirna mirnas monocyte monocytes monocytic osteoclast p65 promoters proper rheumatoid shutting tnfaip3 upregulates upregulating upregulation whereby
Tagcloud (Intersection) ?