IL13RA2 and BRMS1

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		IL13RA2	BRMS1
Description		interleukin 13 receptor subunit alpha 2	BRMS1 transcriptional repressor and anoikis regulator
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex	Nucleus Nucleoplasm Cytoplasm Sin3-type Complex
	Molecular Function	Cytokine Receptor Activity Protein Binding Cytokine Binding	Protein Binding Histone Deacetylase Binding NF-kappaB Binding
	Biological Process	Negative Regulation Of Immunoglobulin Production Cell Surface Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Transforming Growth Factor Beta1 Production Interleukin-13-mediated Signaling Pathway Negative Regulation Of Mast Cell Degranulation	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Regulation Of Gene Expression Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Protein Deacetylation Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Anoikis
Pathways		Interleukin-4 and Interleukin-13 signaling	HDACs deacetylate histones Potential therapeutics for SARS
Drugs		AER001
Diseases
GWAS			Bipolar disorder ( 21926972 31043756)
Interacting Genes		17 interacting genes: AKT1 BAG4 BRMS1 CASP8 EGFR ERBB2 ESR2 IGF1R IL13 IL4 IL4R NOTCH2 PALB2 PAX2 PIK3CA PLPP6 RB1CC1	50 interacting genes: ANGPTL4 APP ARID4A BEX2 BRMS1L CEP70 CSNK2A1 CYTOR DIRAS3 DNAJB1 DNAJB6 E2F1 EEF1A1 EP300 GOLGB1 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HSP90AA1 HSPA4 IL13RA2 ING1 KLK9 KPNA5 LRIF1 LYPD3 MCRS1 MRC2 NMI PFDN5 PSMC3IP RBBP4 RBBP7 RBP1 RELA SAP30 SIN3A SMARCE1 SMTN SNAI1 SNX6 SPOP SRC SUDS3 TAF1 THRSP UBE2D1
Entrez ID		3598	25855
HPRD ID		02132	05879
Ensembl ID		ENSG00000123496	ENSG00000174744
Uniprot IDs		Q14627	G5E9I4 Q9HCU9
PDB IDs		3LB6	2XUS 4AUV
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Population Proliferation Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Multicellular Organismal Process Immune System Process Response To Epidermal Growth Factor Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Metabolic Process ERBB Signaling Pathway Receptor Complex Positive Regulation Of Epithelial Cell Proliferation Enzyme-linked Receptor Protein Signaling Pathway Cell Activation Animal Organ Development Positive Regulation Of Immune System Process Regulation Of Developmental Process Positive Regulation Of Cold-induced Thermogenesis Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Cell Differentiation Regulation Of Immune System Process Response To Lipid Positive Regulation Of Signal Transduction Regulation Of Metabolic Process Negative Regulation Of Complement-dependent Cytotoxicity Positive Regulation Of Cell Migration Positive Regulation Of Cell Differentiation Leukocyte Activation Apoptotic Process Regulation Of Cold-induced Thermogenesis Positive Regulation Of Cell Motility Positive Regulation Of Cell Communication Positive Regulation Of Signaling Programmed Cell Death Positive Regulation Of Developmental Process Positive Regulation Of Locomotion Cell Death Transmembrane Receptor Protein Tyrosine Kinase Activity Negative Regulation Of Developmental Process Defense Response Interleukin-4-mediated Signaling Pathway Regulation Of Cell Migration Regulation Of Cell Activation	Sin3-type Complex Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Histone Deacetylase Complex Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Stem Cell Population Maintenance Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Chromatin Organization Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Histone Deacetylase Activity Regulation Of Primary Metabolic Process Histone Deacetylase Activity, Hydrolytic Mechanism Histone Deacetylase Binding Chromatin Remodeling Protein Lysine Deacetylase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of RNA Metabolic Process Epigenetic Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Negative Regulation Of Signal Transduction Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Locomotion Negative Regulation Of Developmental Process Nucleus Nucleoplasm Positive Regulation Of Developmental Process Negative Regulation Of Cell Migration Positive Regulation Of Multicellular Organismal Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Motility Negative Regulation Of Multicellular Organismal Process Regulation Of Protein Metabolic Process Protein-containing Complex
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