IL13RA2 and RB1CC1

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		IL13RA2	RB1CC1
Description		interleukin 13 receptor subunit alpha 2	RB1 inducible coiled-coil 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex	Phagophore Assembly Site Autophagosome Membrane Nucleus Cytoplasm Lysosome Vacuole Endoplasmic Reticulum Membrane Cytosol Organelle Membrane Nuclear Membrane Phagophore Assembly Site Membrane Atg1/ULK1 Kinase Complex
	Molecular Function	Cytokine Receptor Activity Protein Binding Cytokine Binding	Protein Binding Protein Kinase Binding Protein-membrane Adaptor Activity Molecular Adaptor Activity
	Biological Process	Negative Regulation Of Immunoglobulin Production Cell Surface Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Transforming Growth Factor Beta1 Production Interleukin-13-mediated Signaling Pathway Negative Regulation Of Mast Cell Degranulation	Autophagosome Assembly Autophagy Of Mitochondrion Pexophagy Liver Development Autophagy Apoptotic Process Heart Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Autophagy Ribophagy Piecemeal Microautophagy Of The Nucleus Negative Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Cell Size Positive Regulation Of JNK Cascade Defense Response To Virus Reticulophagy Glycophagy Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Interleukin-4 and Interleukin-13 signaling	Macroautophagy
Drugs		AER001
Diseases
GWAS			Body size at age 10 ( 32376654) Immunoglobulin light chain (AL) amyloidosis (liver involvement) ( 28679651) Mitochondrial DNA copy number (white blood cells) ( 30704525) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		17 interacting genes: AKT1 BAG4 BRMS1 CASP8 EGFR ERBB2 ESR2 IGF1R IL13 IL4 IL4R NOTCH2 PALB2 PAX2 PIK3CA PLPP6 RB1CC1	35 interacting genes: ATG12 AZI2 BAP1 BLID CALCOCO2 COP1 EPSTI1 ERRFI1 EXOC1 GABARAP GABARAPL1 GABARAPL2 GLCE GREB1 HBP1 IL13RA2 IL24 ITIH5 LYPD3 MADD MECOM MRC2 NSD3 PSMC3IP PTK2 PTK2B RNF20 SYN1 THRSP UBC UMPS VAPA VHL VPS45 WIF1
Entrez ID		3598	9821
HPRD ID		02132	06019
Ensembl ID		ENSG00000123496	ENSG00000023287
Uniprot IDs		Q14627	Q8TDY2
PDB IDs		3LB6	6DCE 6GMA 7CZG 7CZM 7D0E 7EA2 7EAA 8SOI 8SQZ 8SRM 8W6B 8YFK 8YFL 8YFM 8YFN 9C82 9D34
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Population Proliferation Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Multicellular Organismal Process Immune System Process Response To Epidermal Growth Factor Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Metabolic Process ERBB Signaling Pathway Receptor Complex Positive Regulation Of Epithelial Cell Proliferation Enzyme-linked Receptor Protein Signaling Pathway Cell Activation Animal Organ Development Positive Regulation Of Immune System Process Regulation Of Developmental Process Positive Regulation Of Cold-induced Thermogenesis Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Cell Differentiation Regulation Of Immune System Process Response To Lipid Positive Regulation Of Signal Transduction Regulation Of Metabolic Process Negative Regulation Of Complement-dependent Cytotoxicity Positive Regulation Of Cell Migration Positive Regulation Of Cell Differentiation Leukocyte Activation Apoptotic Process Regulation Of Cold-induced Thermogenesis Positive Regulation Of Cell Motility Positive Regulation Of Cell Communication Positive Regulation Of Signaling Programmed Cell Death Positive Regulation Of Developmental Process Positive Regulation Of Locomotion Cell Death Transmembrane Receptor Protein Tyrosine Kinase Activity Negative Regulation Of Developmental Process Defense Response Interleukin-4-mediated Signaling Pathway Regulation Of Cell Migration Regulation Of Cell Activation	Autophagosome Membrane Autophagosome Cellular Response To Nitrogen Starvation Autophagosome Maturation Phosphatidylethanolamine Binding GABA Receptor Binding Autophagy Of Mitochondrion Macroautophagy Autophagosome Assembly Autophagosome Organization Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Beta-tubulin Binding Signal Complex Assembly Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein-containing Complex Disassembly Mitophagy Glycophagy Epidermal Growth Factor Receptor Signaling Pathway Apoptotic Process Ubiquitin Protein Ligase Binding Autophagy Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Tag Activity Vacuole Organization Regulation Of Autophagosome Maturation Programmed Cell Death Cell Death ERBB Signaling Pathway Protein Localization To Endoplasmic Reticulum Positive Regulation Of Proteolysis Glycogen Catabolic Process Regulation Of Proteolysis Histone H3 Methyltransferase Activity Catabolic Process Polysaccharide Catabolic Process Regulation Of Macrophage Chemotaxis Cellular Response To Fluid Shear Stress Neurotransmitter Receptor Regulator Activity Orotidine-5'-phosphate Decarboxylase Activity Orotate Phosphoribosyltransferase Activity Nucleate Erythrocyte Differentiation Thrombocyte Differentiation Golgi Membrane Phospholipid Binding Heparosan-N-sulfate-glucuronate 5-epimerase Activity Meiotic Joint Molecule Formation DNA Recombinase Auxiliary Factor Complex Recombinase Activator Activity Meiotic Strand Invasion Involved In Reciprocal Meiotic Recombination Histone H3K4 Dimethyltransferase Activity
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