AQP2 and CCDC167

Number of citations of the paper that reports this interaction (PubMedID 28931009)
46

Data Source:
BioGRID (two hybrid)

		AQP2	CCDC167
Description		aquaporin 2	coiled-coil domain containing 167
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Transport Vesicle Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Lumenal Side Of Membrane	Membrane
	Molecular Function	Water Transmembrane Transporter Activity Protein Binding Glycerol Transmembrane Transporter Activity Water Channel Activity Channel Activity	Protein Binding
	Biological Process	Renal Water Homeostasis Renal Water Transport Water Transport Actin Filament Organization Glycerol Transmembrane Transport Cellular Response To Water Deprivation Protein Homotetramerization Transmembrane Transport Cellular Response To Copper Ion Cellular Response To Mercury Ion Metanephric Collecting Duct Development
Pathways		Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins
Drugs
Diseases		Congenital nephrogenic diabetes insipidus (NDI)
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Obsessive-compulsive disorder ( 22889921)	Acne (severe) ( 24927181) Restless legs syndrome ( 29029846) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		60 interacting genes: ACTB ARLN BCAP31 CCDC167 CDIPT CERT1 CLCA4 CLDN7 CREB3 CREB3L1 CTSA CXCL16 EEF1A1 EFNA5 ELL2 ERG28 ERGIC3 ERMP1 FAM209A GPAA1 GPX8 IER3 IGFBP5 INSIG2 LEUTX LHFPL5 MRM1 MS4A13 MUC1 NDFIP2 OLFM4 OR10AG1 PANX1 PDZK1IP1 PLP2 PNLIPRP1 RTP2 SLC26A6 SLC30A2 SLC38A7 SLC5A2 SNAP47 SNX5 SPCS1 SSR3 STUB1 STX8 SUPT20H TM9SF2 TMEM109 TMEM218 TMEM230 TMEM236 TMEM60 TMEM86A TMEM97 TRARG1 UBE2J1 VAPB YIPF6	46 interacting genes: APPBP2 AQP2 AQP6 AQP9 ARL13B CD79A CFTR CLDN5 CX3CR1 EBP ELOVL4 ERGIC3 FAM174A FAM210B FFAR2 FOXP1 GJA8 GLP1R GOLT1A GPR152 GPR42 GPX8 HSD17B13 MS4A3 MTNR1A MUC1 NIPA1 OPRM1 RETREG3 SCN3B SERINC2 SLC10A6 SLC18A3 SLC35H1 SLC7A14 SYT2 TACR1 TLCD4 TM4SF19 TMEM179B TMEM237 TMEM51 TMEM80 TMEM86B TMX2 VKORC1
Entrez ID		359	154467
HPRD ID		00141	18561
Ensembl ID		ENSG00000167580	ENSG00000198937
Uniprot IDs		P41181	Q9P0B6
PDB IDs		4NEF 4OJ2 6QF5 8GCL 8GHJ 8OEE 8VVX
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Endoplasmic Reticulum Membrane Response To Endoplasmic Reticulum Stress Endoplasmic Reticulum Unfolded Protein Response Cellular Localization Intracellular Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Regulation Of Cellular Response To Stress Establishment Of Localization In Cell Regulation Of Chaperone-mediated Autophagy Regulation Of Response To Endoplasmic Reticulum Stress COPII-coated ER To Golgi Transport Vesicle Regulation Of Cellular Localization Host-mediated Activation Of Viral Genome Replication Carbohydrate Transmembrane Transport	Membrane Water Transport Fluid Transport Transmembrane Transport Water Channel Activity G Protein-coupled Receptor Activity Plasma Membrane Organic Hydroxy Compound Transport Glycerol Transmembrane Transport G Protein-coupled Peptide Receptor Activity Positive Regulation Of Synaptic Transmission, Cholinergic Channel Activity Renal Water Transport Protein Binding Polyol Transmembrane Transport Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Endoplasmic Reticulum
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