AQP2 and SLC5A2

Number of citations of the paper that reports this interaction (PubMedID 28931009)
46

Data Source:
BioGRID (two hybrid)

		AQP2	SLC5A2
Description		aquaporin 2	solute carrier family 5 member 2
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GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Transport Vesicle Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Lumenal Side Of Membrane	Plasma Membrane Membrane Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Water Transmembrane Transporter Activity Protein Binding Glycerol Transmembrane Transporter Activity Water Channel Activity Channel Activity	Low-affinity D-glucose:sodium Symporter Activity D-glucose:sodium Symporter Activity Protein Binding Alpha-glucoside Transmembrane Transporter Activity Symporter Activity Solute:sodium Symporter Activity Transmembrane Transporter Activity Metal Ion Binding D-glucose Transmembrane Transporter Activity
	Biological Process	Renal Water Homeostasis Renal Water Transport Water Transport Actin Filament Organization Glycerol Transmembrane Transport Cellular Response To Water Deprivation Protein Homotetramerization Transmembrane Transport Cellular Response To Copper Ion Cellular Response To Mercury Ion Metanephric Collecting Duct Development	Alpha-glucoside Transport Carbohydrate Metabolic Process Monoatomic Ion Transport Sodium Ion Transport Hexose Transmembrane Transport Renal D-glucose Absorption Transmembrane Transport D-glucose Import Across Plasma Membrane Sodium Ion Import Across Plasma Membrane D-glucose Transmembrane Transport
Pathways		Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins	Cellular hexose transport Defective SLC5A2 causes renal glucosuria (GLYS1)
Drugs			Dapagliflozin Canagliflozin Empagliflozin Ertugliflozin Sotagliflozin
Diseases		Congenital nephrogenic diabetes insipidus (NDI)
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Obsessive-compulsive disorder ( 22889921)	Glucosuria ( 30476138) Glucosuria (mild) ( 30476138) Glucosuria (moderate to severe) ( 30476138)
Interacting Genes		60 interacting genes: ACTB ARLN BCAP31 CCDC167 CDIPT CERT1 CLCA4 CLDN7 CREB3 CREB3L1 CTSA CXCL16 EEF1A1 EFNA5 ELL2 ERG28 ERGIC3 ERMP1 FAM209A GPAA1 GPX8 IER3 IGFBP5 INSIG2 LEUTX LHFPL5 MRM1 MS4A13 MUC1 NDFIP2 OLFM4 OR10AG1 PANX1 PDZK1IP1 PLP2 PNLIPRP1 RTP2 SLC26A6 SLC30A2 SLC38A7 SLC5A2 SNAP47 SNX5 SPCS1 SSR3 STUB1 STX8 SUPT20H TM9SF2 TMEM109 TMEM218 TMEM230 TMEM236 TMEM60 TMEM86A TMEM97 TRARG1 UBE2J1 VAPB YIPF6	1 interacting genes: AQP2
Entrez ID		359	6524
HPRD ID		00141	08919
Ensembl ID		ENSG00000167580	ENSG00000140675
Uniprot IDs		P41181	P31639 Q8WY15
PDB IDs		4NEF 4OJ2 6QF5 8GCL 8GHJ 8OEE 8VVX	7VSI 7YNJ 7YNK 8HB0 8HDH 8HEZ 8HG7 8HIN
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Endoplasmic Reticulum Membrane Response To Endoplasmic Reticulum Stress Endoplasmic Reticulum Unfolded Protein Response Cellular Localization Intracellular Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Regulation Of Cellular Response To Stress Establishment Of Localization In Cell Regulation Of Chaperone-mediated Autophagy Regulation Of Response To Endoplasmic Reticulum Stress COPII-coated ER To Golgi Transport Vesicle Regulation Of Cellular Localization Host-mediated Activation Of Viral Genome Replication Carbohydrate Transmembrane Transport	Lumenal Side Of Membrane Cellular Response To Mercury Ion Cellular Response To Water Deprivation Glycerol Transmembrane Transporter Activity Positive Regulation Of Platelet-derived Growth Factor Production Regulation Of Platelet-derived Growth Factor Production Polyol Transmembrane Transport Renal Water Transport Response To Water Deprivation Glycerol Transmembrane Transport Water Transmembrane Transporter Activity Metanephric Collecting Duct Development Response To Mercury Ion Positive Regulation Of Glomerular Mesangial Cell Proliferation Positive Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Cell Proliferation Involved In Kidney Development Response To Water Regulation Of Glomerular Mesangial Cell Proliferation Collecting Duct Development Water Channel Activity Renal Water Homeostasis Positive Regulation Of Transforming Growth Factor Beta Production Cellular Response To Copper Ion Positive Regulation Of Collagen Biosynthetic Process Water Transport Multicellular Organismal-level Water Homeostasis Fluid Transport Response To Copper Ion Channel Activity Regulation Of Collagen Biosynthetic Process Carbohydrate Transmembrane Transport Regulation Of Collagen Metabolic Process Carbohydrate Transport Transport Vesicle Membrane Protein Homotetramerization Multicellular Organismal-level Chemical Homeostasis Serine-type Endopeptidase Inhibitor Activity Protein Tetramerization Peptidase Inhibitor Activity Renal System Process Recycling Endosome Organic Hydroxy Compound Transport Cellular Response To Metal Ion Cytoplasmic Vesicle Membrane
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