AQP2 and TMEM230

Number of citations of the paper that reports this interaction (PubMedID 28931009)
46

Data Source:
BioGRID (two hybrid)

		AQP2	TMEM230
Description		aquaporin 2	transmembrane protein 230
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Transport Vesicle Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Lumenal Side Of Membrane	Endosome Early Endosome Late Endosome Autophagosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Synaptic Vesicle Endomembrane System Membrane Axon Cytoplasmic Vesicle Synapse Recycling Endosome
	Molecular Function	Water Transmembrane Transporter Activity Protein Binding Glycerol Transmembrane Transporter Activity Water Channel Activity Channel Activity	Protein Binding
	Biological Process	Renal Water Homeostasis Renal Water Transport Water Transport Actin Filament Organization Glycerol Transmembrane Transport Cellular Response To Water Deprivation Protein Homotetramerization Transmembrane Transport Cellular Response To Copper Ion Cellular Response To Mercury Ion Metanephric Collecting Duct Development	Synaptic Vesicle Transport Axonal Transport
Pathways		Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins
Drugs
Diseases		Congenital nephrogenic diabetes insipidus (NDI)
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Obsessive-compulsive disorder ( 22889921)
Interacting Genes		60 interacting genes: ACTB ARLN BCAP31 CCDC167 CDIPT CERT1 CLCA4 CLDN7 CREB3 CREB3L1 CTSA CXCL16 EEF1A1 EFNA5 ELL2 ERG28 ERGIC3 ERMP1 FAM209A GPAA1 GPX8 IER3 IGFBP5 INSIG2 LEUTX LHFPL5 MRM1 MS4A13 MUC1 NDFIP2 OLFM4 OR10AG1 PANX1 PDZK1IP1 PLP2 PNLIPRP1 RTP2 SLC26A6 SLC30A2 SLC38A7 SLC5A2 SNAP47 SNX5 SPCS1 SSR3 STUB1 STX8 SUPT20H TM9SF2 TMEM109 TMEM218 TMEM230 TMEM236 TMEM60 TMEM86A TMEM97 TRARG1 UBE2J1 VAPB YIPF6	14 interacting genes: AQP2 ARL4D CREB3 ERBB2 ERBB3 ERBB4 HTR4 LMNA MTNR1A MTNR1B RPL28 SGTA TMEM9 VKORC1
Entrez ID		359	29058
HPRD ID		00141	12762
Ensembl ID		ENSG00000167580	ENSG00000089063
Uniprot IDs		P41181	A0A087WTT2 Q96A57
PDB IDs		4NEF 4OJ2 6QF5 8GCL 8GHJ 8OEE 8VVX
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Endoplasmic Reticulum Membrane Response To Endoplasmic Reticulum Stress Endoplasmic Reticulum Unfolded Protein Response Cellular Localization Intracellular Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Regulation Of Cellular Response To Stress Establishment Of Localization In Cell Regulation Of Chaperone-mediated Autophagy Regulation Of Response To Endoplasmic Reticulum Stress COPII-coated ER To Golgi Transport Vesicle Regulation Of Cellular Localization Host-mediated Activation Of Viral Genome Replication Carbohydrate Transmembrane Transport	ERBB3:ERBB2 Complex ERBB2 Signaling Pathway Neuregulin Receptor Activity Melatonin Receptor Activity ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Receptor Complex Basal Plasma Membrane Protein-containing Complex Localization ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Basolateral Plasma Membrane ERBB Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Membrane Regulation Of Body Fluid Levels Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Protein Tyrosine Kinase Activity Peripheral Nervous System Development Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Regulation Of Biological Quality Growth Factor Binding Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Epithelial Cell Proliferation Transmembrane Receptor Protein Tyrosine Kinase Activity Localization Within Membrane Peptidyl-tyrosine Phosphorylation Response To Epidermal Growth Factor Receptor Localization To Synapse Animal Organ Development Establishment Of Planar Polarity Involved In Nephron Morphogenesis Large Intestinal Transit Negative Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Deacetylase Activity Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Protein Localization To Synapse Heart Development Glial Cell Development Lumenal Side Of Membrane Glycerol Transmembrane Transporter Activity Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Cardiac Muscle Tissue Development
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