AQP2 and TM9SF2

Number of citations: 46 (PubMedID 28931009)
Data Source: BioGRID (two hybrid)

		AQP2	TM9SF2
Name		aquaporin 2	transmembrane 9 superfamily member 2
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Transport Vesicle Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Lumenal Side Of Membrane	Cytoplasm Endosome Golgi Apparatus Microtubule Organizing Center Cytoskeleton Plasma Membrane Endosome Membrane Membrane Extracellular Exosome
	Molecular Function	Water Transmembrane Transporter Activity Protein Binding Glycerol Transmembrane Transporter Activity Water Channel Activity Channel Activity	None
	Biological Process	Renal Water Homeostasis Renal Water Transport Water Transport Actin Filament Organization Glycerol Transmembrane Transport Cellular Response To Water Deprivation Protein Homotetramerization Transmembrane Transport Cellular Response To Copper Ion Cellular Response To Mercury Ion Metanephric Collecting Duct Development	Ceramide Metabolic Process Glycosphingolipid Biosynthetic Process Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Protein Localization To Membrane
Pathways		Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins	None
Diseases		Congenital nephrogenic diabetes insipidus (NDI)	None
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Allergic rhinitis ( 30013184 ) Obsessive-compulsive disorder ( 22889921 )	Asthma ( 30929738 31619474 32296059 34103634 ) Asthma (adult onset) ( 30929738 ) Asthma (childhood onset) ( 31036433 ) Metabolite levels ( 23823483 ) Obesity-related traits ( 23251661 ) Periodontal disease-related phenotype (Socransky) ( 26962152 )
Novel Interactors		1 novel interactors: LMAN2L	None recorded
Interacting Genes		60 interacting genes: ACTB ARLN BCAP31 CCDC167 CDIPT CERT1 CLCA4 CLDN7 CREB3 CREB3L1 CTSA CXCL16 EEF1A1 EFNA5 ELL2 ERG28 ERGIC3 ERMP1 FAM209A GPAA1 GPX8 IER3 IGFBP5 INSIG2 LEUTX LHFPL5 MRM1 MS4A13 MUC1 NDFIP2 OLFM4 OR10AG1 PANX1 PDZK1IP1 PLP2 PNLIPRP1 RTP2 SLC26A6 SLC30A2 SLC38A7 SLC5A2 SNAP47 SNX5 SPCS1 SSR3 STUB1 STX8 SUPT20H TM9SF2 TMEM109 TMEM218 TMEM230 TMEM236 TMEM60 TMEM86A TMEM97 TRARG1 UBE2J1 VAPB YIPF6	4 interacting genes: AQP2 HTR2C RAB9A SMAD4
Entrez ID		359	9375
HPRD ID		00141	09198
Ensembl ID		ENSG00000167580	ENSG00000125304
Uniprot IDs		P41181	A0A024QYR8 Q99805
PDB IDs		4NEF 4OJ2 6QF5 8GCL 8GHJ 8OEE 8VVX	Not available
GO Terms Enriched among Interactors		Endoplasmic Reticulum Membrane Endoplasmic Reticulum Membrane Response To Endoplasmic Reticulum Stress Endoplasmic Reticulum Unfolded Protein Response Cellular Localization Intracellular Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Regulation Of Cellular Response To Stress Establishment Of Localization In Cell Regulation Of Chaperone-mediated Autophagy Regulation Of Response To Endoplasmic Reticulum Stress COPII-coated ER To Golgi Transport Vesicle Regulation Of Cellular Localization Host-mediated Activation Of Viral Genome Replication Carbohydrate Transmembrane Transport	Lumenal Side Of Membrane Cellular Response To Mercury Ion Cellular Response To Water Deprivation Cytoplasmic Vesicle Membrane Chemical Homeostasis Glycerol Transmembrane Transporter Activity Gq/11-coupled Serotonin Receptor Activity Positive Regulation Of Phosphatidylinositol Biosynthetic Process 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding Intracellular Signaling Cassette Regulation Of Secretion Regulation Of Secretion By Cell Activin Responsive Factor Complex Left Ventricular Cardiac Muscle Tissue Morphogenesis Gonad Morphogenesis Negative Regulation Of Cardiac Myofibril Assembly Nephrogenic Mesenchyme Morphogenesis Metanephric Mesenchyme Morphogenesis Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Renal Water Transport Response To Water Deprivation Glycerol Transmembrane Transport Water Transmembrane Transporter Activity Tube Development Homeostatic Process Regulation Of Hormone Secretion Regulation Of ERK1 And ERK2 Cascade G Protein-coupled Serotonin Receptor Complex Phospholipase C-activating Serotonin Receptor Signaling Pathway Regulation Of Corticotropin-releasing Hormone Secretion SMAD Protein Complex Positive Regulation Of Luteinizing Hormone Secretion Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Atrioventricular Valve Formation Sebaceous Gland Development Heteromeric SMAD Protein Complex Formation Of Anatomical Boundary Positive Regulation Of Secretion By Cell Brainstem Development Mesendoderm Development Sulfate Binding Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Regulation Of Transforming Growth Factor Beta2 Production Endocardial Cell Differentiation Polyol Transmembrane Transport Metanephric Collecting Duct Development Response To Mercury Ion Serotonin Binding