CCDC167 and SYT2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CCDC167	SYT2
Description		coiled-coil domain containing 167	synaptotagmin 2
Image		No pdb structure
GO Annotations	Cellular Component	Membrane	Cytoplasm Plasma Membrane Membrane Axon Clathrin-coated Endocytic Vesicle Membrane Synaptic Vesicle Membrane Dense Core Granule Cytoplasmic Vesicle Chromaffin Granule Membrane Synapse Exocytic Vesicle
	Molecular Function	Protein Binding	SNARE Binding Protein Binding Calcium-dependent Phospholipid Binding Inositol 1,3,4,5 Tetrakisphosphate Binding Metal Ion Binding Calcium Ion Sensor Activity
	Biological Process		Vesicle-mediated Transport Regulation Of Calcium Ion-dependent Exocytosis Cell Differentiation Calcium-dependent Activation Of Synaptic Vesicle Fusion Positive Regulation Of Dendrite Extension Regulation Of Synaptic Vesicle Exocytosis
Pathways			Toxicity of botulinum toxin type B (botB) Neurexins and neuroligins Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs			Botulinum toxin type B
Diseases
GWAS		Acne (severe) ( 24927181) Restless legs syndrome ( 29029846) Smoking status (ever vs never smokers) ( 30643258)	Celiac disease ( 23936387) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383)
Interacting Genes		46 interacting genes: APPBP2 AQP2 AQP6 AQP9 ARL13B CD79A CFTR CLDN5 CX3CR1 EBP ELOVL4 ERGIC3 FAM174A FAM210B FFAR2 FOXP1 GJA8 GLP1R GOLT1A GPR152 GPR42 GPX8 HSD17B13 MS4A3 MTNR1A MUC1 NIPA1 OPRM1 RETREG3 SCN3B SERINC2 SLC10A6 SLC18A3 SLC35H1 SLC7A14 SYT2 TACR1 TLCD4 TM4SF19 TMEM179B TMEM237 TMEM51 TMEM80 TMEM86B TMX2 VKORC1	29 interacting genes: AQP10 BNIP2 CCDC167 CLDN4 CMTM3 FA2H FUNDC2 ITGAM KLHL3 LAT MALL MIP NAPB NRXN1 ORMDL3 PLPP4 PMP22 SLC30A8 SLC35A1 SLC35A4 STON2 SYNCRIP TF THSD7B TMEM107 TMEM229B TSPO2 VAMP4 WNK1
Entrez ID		154467	127833
HPRD ID		18561	02520
Ensembl ID		ENSG00000198937	ENSG00000143858
Uniprot IDs		Q9P0B6	Q8N9I0
PDB IDs			6G5G
Enriched GO Terms of Interacting Partners?		Membrane Water Transport Fluid Transport Transmembrane Transport Water Channel Activity G Protein-coupled Receptor Activity Plasma Membrane Organic Hydroxy Compound Transport Glycerol Transmembrane Transport G Protein-coupled Peptide Receptor Activity Positive Regulation Of Synaptic Transmission, Cholinergic Channel Activity Renal Water Transport Protein Binding Polyol Transmembrane Transport Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Endoplasmic Reticulum	Membrane Pyrimidine Nucleotide-sugar Transmembrane Transporter Activity Transmembrane Transport Pyrimidine Nucleotide-sugar Transmembrane Transport Nucleotide-sugar Transmembrane Transport Homeostatic Process Endocytic Vesicle Water Channel Activity Chemical Homeostasis
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