AQP2 and SSR3

Number of citations of the paper that reports this interaction (PubMedID 28931009)
46

Data Source:
BioGRID (two hybrid)

		AQP2	SSR3
Description		aquaporin 2	signal sequence receptor subunit 3
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Transport Vesicle Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Lumenal Side Of Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Water Transmembrane Transporter Activity Protein Binding Glycerol Transmembrane Transporter Activity Water Channel Activity Channel Activity	Protein Binding
	Biological Process	Renal Water Homeostasis Renal Water Transport Water Transport Actin Filament Organization Glycerol Transmembrane Transport Cellular Response To Water Deprivation Protein Homotetramerization Transmembrane Transport Cellular Response To Copper Ion Cellular Response To Mercury Ion Metanephric Collecting Duct Development	SRP-dependent Cotranslational Protein Targeting To Membrane
Pathways		Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins	SRP-dependent cotranslational protein targeting to membrane
Drugs
Diseases		Congenital nephrogenic diabetes insipidus (NDI)
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Obsessive-compulsive disorder ( 22889921)	Asthma (adult onset) ( 30929738) Chronotype ( 30696823) Malaria ( 31844061) Metabolite levels ( 23823483) Testicular germ cell tumor ( 28604732)
Interacting Genes		60 interacting genes: ACTB ARLN BCAP31 CCDC167 CDIPT CERT1 CLCA4 CLDN7 CREB3 CREB3L1 CTSA CXCL16 EEF1A1 EFNA5 ELL2 ERG28 ERGIC3 ERMP1 FAM209A GPAA1 GPX8 IER3 IGFBP5 INSIG2 LEUTX LHFPL5 MRM1 MS4A13 MUC1 NDFIP2 OLFM4 OR10AG1 PANX1 PDZK1IP1 PLP2 PNLIPRP1 RTP2 SLC26A6 SLC30A2 SLC38A7 SLC5A2 SNAP47 SNX5 SPCS1 SSR3 STUB1 STX8 SUPT20H TM9SF2 TMEM109 TMEM218 TMEM230 TMEM236 TMEM60 TMEM86A TMEM97 TRARG1 UBE2J1 VAPB YIPF6	5 interacting genes: AQP2 PDE4B PRRC2A RABAC1 SSR4
Entrez ID		359	6747
HPRD ID		00141	16206
Ensembl ID		ENSG00000167580	ENSG00000114850
Uniprot IDs		P41181	C9J365 Q9UNL2
PDB IDs		4NEF 4OJ2 6QF5 8GCL 8GHJ 8OEE 8VVX	8B6L
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Endoplasmic Reticulum Membrane Response To Endoplasmic Reticulum Stress Endoplasmic Reticulum Unfolded Protein Response Cellular Localization Intracellular Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Regulation Of Cellular Response To Stress Establishment Of Localization In Cell Regulation Of Chaperone-mediated Autophagy Regulation Of Response To Endoplasmic Reticulum Stress COPII-coated ER To Golgi Transport Vesicle Regulation Of Cellular Localization Host-mediated Activation Of Viral Genome Replication Carbohydrate Transmembrane Transport	Lumenal Side Of Membrane Polyol Transmembrane Transport Renal Water Transport Response To Water Deprivation Glycerol Transmembrane Transport Water Transmembrane Transporter Activity Cellular Response To Mercury Ion Metanephric Collecting Duct Development Cellular Response To Water Deprivation Glycerol Transmembrane Transporter Activity Response To Mercury Ion Basolateral Plasma Membrane Positive Regulation Of Cardiac Muscle Tissue Development ErbB-3 Class Receptor Binding ERBB3:ERBB2 Complex Neuregulin Receptor Activity ERBB2-ERBB3 Signaling Pathway Schwann Cell Differentiation ERBB3 Signaling Pathway Neuregulin Binding Regulation Of Cardiac Muscle Tissue Development Neutrophil Homeostasis Synaptic Vesicle Negative Regulation Of Relaxation Of Muscle CAMP Catabolic Process Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Negative Regulation Of Relaxation Of Cardiac Muscle Regulation Of Relaxation Of Cardiac Muscle Sec61 Translocon Complex Response To Water Negative Regulation Of Motor Neuron Apoptotic Process Gamma-tubulin Complex Membrane Collecting Duct Development Endocardial Cushion Development Cellular Response To Epinephrine Stimulus Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Water Channel Activity Regulation Of Motor Neuron Apoptotic Process Motor Neuron Apoptotic Process Cyclic Nucleotide Catabolic Process Response To Epinephrine Protein Tyrosine Kinase Activator Activity Regulation Of Relaxation Of Muscle Apical Plasma Membrane Renal Water Homeostasis Plasma Membrane Schwann Cell Development Positive Regulation Of Calcineurin-NFAT Signaling Cascade 3',5'-cyclic-AMP Phosphodiesterase Activity
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