AQP2 and GPX8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AQP2	GPX8
Description		aquaporin 2	glutathione peroxidase 8 (putative)
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Transport Vesicle Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Lumenal Side Of Membrane	Endoplasmic Reticulum Lumen Membrane
	Molecular Function	Water Transmembrane Transporter Activity Protein Binding Glycerol Transmembrane Transporter Activity Water Channel Activity Channel Activity	Peroxidase Activity Glutathione Peroxidase Activity Protein Binding Oxidoreductase Activity
	Biological Process	Renal Water Homeostasis Renal Water Transport Water Transport Actin Filament Organization Glycerol Transmembrane Transport Cellular Response To Water Deprivation Protein Homotetramerization Transmembrane Transport Cellular Response To Copper Ion Cellular Response To Mercury Ion Metanephric Collecting Duct Development	Response To Oxidative Stress Cellular Response To Oxidative Stress Cellular Oxidant Detoxification
Pathways		Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins	Detoxification of Reactive Oxygen Species
Drugs			Glutathione Glutathione disulfide Benzoyl peroxide
Diseases		Congenital nephrogenic diabetes insipidus (NDI)
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Obsessive-compulsive disorder ( 22889921)	Cocaine dependence ( 31212010)
Interacting Genes		60 interacting genes: ACTB ARLN BCAP31 CCDC167 CDIPT CERT1 CLCA4 CLDN7 CREB3 CREB3L1 CTSA CXCL16 EEF1A1 EFNA5 ELL2 ERG28 ERGIC3 ERMP1 FAM209A GPAA1 GPX8 IER3 IGFBP5 INSIG2 LEUTX LHFPL5 MRM1 MS4A13 MUC1 NDFIP2 OLFM4 OR10AG1 PANX1 PDZK1IP1 PLP2 PNLIPRP1 RTP2 SLC26A6 SLC30A2 SLC38A7 SLC5A2 SNAP47 SNX5 SPCS1 SSR3 STUB1 STX8 SUPT20H TM9SF2 TMEM109 TMEM218 TMEM230 TMEM236 TMEM60 TMEM86A TMEM97 TRARG1 UBE2J1 VAPB YIPF6	170 interacting genes: AGTRAP AIG1 ALG8 ANKRD46 APOC3 APOD AQP1 AQP2 AQP3 ARLN ASGR1 ASPH BCL2L2 BET1 BIK BMP10 BNIP2 BTN2A2 C14orf180 C1GALT1 C3orf52 CACNG1 CCDC167 CD302 CD53 CD81 CDIPT CDS2 CFHR5 CHST1 CLDN19 CLDND2 CLEC1A CLEC2A CMTM5 CNIH1 CNIH3 COL4A5 COL8A2 CORIN CXCL16 CYB561 CYB561A3 CYB561D2 CYBC1 DNAJC30 DOLK EDDM3B ERG28 ERO1A FA2H FAM3C FAXDC2 GET3 GIMAP1 GOSR2 GPR151 GPR37L1 GRINA GYPA HHATL HMOX2 IGFBP5 INSIG2 ITGAM KIR2DL3 KLRG1 LAPTM4B LEPROTL1 LHFPL5 LNPEP LPAR3 MAN2B2 MARCHF2 MARCHF5 MFSD6 MGST2 MGST3 MIP MMD MYADML2 NEU1 NINJ1 NINJ2 NIPAL3 NKG7 NRM OCLN PAEP PAQR5 PAQR6 PGAP2 PLLP PLN PLP2 PLPP4 PLPP6 PMP22 PNLIPRP1 PRB1 RBFA RND1 RPRM RTP2 SCARB2 SCARF1 SCD SEC22B SELENOK SERINC1 SERINC2 SERP1 SERTM1 SFTPC SGMS2 SLC13A3 SLC30A3 SLC34A3 SLC35A1 SLC35B4 SLC38A7 SLC41A2 SLC61A1 SMAGP SNORC ST6GAL2 STX3 STX8 SYT15 SYT15B TF THBD TIMMDC1 TM4SF4 TMBIM6 TMEM107 TMEM109 TMEM11 TMEM120B TMEM128 TMEM14B TMEM14C TMEM19 TMEM203 TMEM218 TMEM229B TMEM243 TMEM254 TMEM42 TMEM50B TMEM60 TMEM86A TMEM86B TMEM97 TMPRSS4 TMUB2 TRAM1L1 TSPAN33 TSPO2 UNC50 UPK1B VAMP3 VAMP4 VAMP5 VKORC1L1 VSTM1 VTI1B YIF1A YIPF6 ZDHHC22
Entrez ID		359	493869
HPRD ID		00141	17416
Ensembl ID		ENSG00000167580	ENSG00000164294
Uniprot IDs		P41181	B4DPY0 E7ETY7 J3KNB5 Q8TED1
PDB IDs		4NEF 4OJ2 6QF5 8GCL 8GHJ 8OEE 8VVX	3CYN 3KIJ
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Endoplasmic Reticulum Membrane Response To Endoplasmic Reticulum Stress Endoplasmic Reticulum Unfolded Protein Response Cellular Localization Intracellular Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Regulation Of Cellular Response To Stress Establishment Of Localization In Cell Regulation Of Chaperone-mediated Autophagy Regulation Of Response To Endoplasmic Reticulum Stress COPII-coated ER To Golgi Transport Vesicle Regulation Of Cellular Localization Host-mediated Activation Of Viral Genome Replication Carbohydrate Transmembrane Transport	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding Plasma Membrane SNAP Receptor Activity SNARE Complex Golgi Membrane Cholesterol Binding Water Channel Activity Glycerol Transmembrane Transport Transmembrane Transport Channel Activity Renal Water Transport Polyol Transmembrane Transport Glycerol Transmembrane Transporter Activity Vesicle-mediated Transport Lysosomal Membrane Presynaptic Endosome Membrane Alkenylglycerophosphocholine Hydrolase Activity Water Transport Golgi Apparatus Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Lipid Metabolic Process Cellular Response To Mercury Ion Ascorbate Homeostasis ER To Golgi Transport Vesicle Membrane Endomembrane System Lysosome Organelle Fusion Fluid Transport Vesicle Fusion SNARE Binding Carbohydrate Binding Transmembrane Monodehydroascorbate Reductase Activity Membrane Destabilizing Activity Compact Myelin Transmembrane Ascorbate Ferrireductase Activity Respiratory Burst After Phagocytosis Organelle Membrane Fusion Monoatomic Ion Transport Sterol Biosynthetic Process Renal Water Homeostasis Metal Ion Transport Negative Regulation Of Lipoprotein Metabolic Process Water Transmembrane Transporter Activity Late Endosome Membrane Leukotriene-C4 Synthase Activity Membrane Fusion
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