AQP2 and TMEM236

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AQP2	TMEM236
Description		aquaporin 2	transmembrane protein 236
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Transport Vesicle Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Lumenal Side Of Membrane	Membrane
	Molecular Function	Water Transmembrane Transporter Activity Protein Binding Glycerol Transmembrane Transporter Activity Water Channel Activity Channel Activity	Protein Binding
	Biological Process	Renal Water Homeostasis Renal Water Transport Water Transport Actin Filament Organization Glycerol Transmembrane Transport Cellular Response To Water Deprivation Protein Homotetramerization Transmembrane Transport Cellular Response To Copper Ion Cellular Response To Mercury Ion Metanephric Collecting Duct Development
Pathways		Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins
Drugs
Diseases		Congenital nephrogenic diabetes insipidus (NDI)
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Obsessive-compulsive disorder ( 22889921)	Allergic disease (asthma, hay fever or eczema) ( 29679657)
Interacting Genes		60 interacting genes: ACTB ARLN BCAP31 CCDC167 CDIPT CERT1 CLCA4 CLDN7 CREB3 CREB3L1 CTSA CXCL16 EEF1A1 EFNA5 ELL2 ERG28 ERGIC3 ERMP1 FAM209A GPAA1 GPX8 IER3 IGFBP5 INSIG2 LEUTX LHFPL5 MRM1 MS4A13 MUC1 NDFIP2 OLFM4 OR10AG1 PANX1 PDZK1IP1 PLP2 PNLIPRP1 RTP2 SLC26A6 SLC30A2 SLC38A7 SLC5A2 SNAP47 SNX5 SPCS1 SSR3 STUB1 STX8 SUPT20H TM9SF2 TMEM109 TMEM218 TMEM230 TMEM236 TMEM60 TMEM86A TMEM97 TRARG1 UBE2J1 VAPB YIPF6	5 interacting genes: AQP2 FAM209A GPR152 OPRM1 TMEM179B
Entrez ID		359	653567
HPRD ID		00141	19339
Ensembl ID		ENSG00000167580	ENSG00000148483
Uniprot IDs		P41181	Q5W0B7
PDB IDs		4NEF 4OJ2 6QF5 8GCL 8GHJ 8OEE 8VVX
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Endoplasmic Reticulum Membrane Response To Endoplasmic Reticulum Stress Endoplasmic Reticulum Unfolded Protein Response Cellular Localization Intracellular Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Regulation Of Cellular Response To Stress Establishment Of Localization In Cell Regulation Of Chaperone-mediated Autophagy Regulation Of Response To Endoplasmic Reticulum Stress COPII-coated ER To Golgi Transport Vesicle Regulation Of Cellular Localization Host-mediated Activation Of Viral Genome Replication Carbohydrate Transmembrane Transport	Lumenal Side Of Membrane Cellular Response To Mercury Ion Cellular Response To Water Deprivation Glycerol Transmembrane Transporter Activity Cellular Response To Morphine Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Response To Water Deprivation Regulation Of NMDA Receptor Activity Water Transmembrane Transporter Activity Polyol Transmembrane Transport Renal Water Transport Glycerol Transmembrane Transport Metanephric Collecting Duct Development Response To Mercury Ion Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Opioid Receptor Activity G Protein-coupled Opioid Receptor Signaling Pathway Behavioral Response To Ethanol Response To Water Water Channel Activity Collecting Duct Development Negative Regulation Of Nitric Oxide Biosynthetic Process G Protein-coupled Receptor Activity Negative Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Neurotransmitter Receptor Activity Response To Morphine Renal Water Homeostasis G Protein-coupled Acetylcholine Receptor Signaling Pathway G-protein Beta-subunit Binding Cellular Response To Copper Ion Water Transport Neuropeptide Binding Multicellular Organismal-level Water Homeostasis G-protein Alpha-subunit Binding Voltage-gated Calcium Channel Activity
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