CCDC167 and CX3CR1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CCDC167	CX3CR1
Description		coiled-coil domain containing 167	C-X3-C motif chemokine receptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Membrane	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Neuronal Cell Body Membrane Neuron Projection Perinuclear Region Of Cytoplasm Dendritic Tree Macropinosome Membrane
	Molecular Function	Protein Binding	Cytokine Receptor Activity G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity C-C Chemokine Receptor Activity C-X3-C Chemokine Receptor Activity C-C Chemokine Binding C-X3-C Chemokine Binding CX3C Chemokine Receptor Binding
	Biological Process		Positive Regulation Of Neuroblast Proliferation Adaptive Immune Response Microglial Cell Activation Involved In Immune Response Immune System Process Response To Ischemia Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Brain Development Response To Wounding Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Calcium-mediated Signaling Central Nervous System Maturation Leukocyte Chemotaxis Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Interleukin-1 Beta Production Social Behavior Autocrine Signaling Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Synaptic Plasticity Host-mediated Modulation Of Intestinal Microbiota Composition Regulation Of Neurogenesis Positive Regulation Of Neurogenesis Modulation Of Chemical Synaptic Transmission Leukocyte Tethering Or Rolling Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Synapse Maturation Cell Chemotaxis Antifungal Innate Immune Response Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Cytokine Stimulus Positive Regulation Of Monocyte Chemotaxis Synapse Pruning Negative Regulation Of Hippocampal Neuron Apoptotic Process Multiple Spine Synapse Organization, Single Dendrite Regulation Of Microglial Cell Migration Negative Regulation Of Microglial Cell Mediated Cytotoxicity Negative Regulation Of Apoptotic Signaling Pathway
Pathways			Chemokine receptors bind chemokines G alpha (i) signalling events Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions
Drugs
Diseases			Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
GWAS		Acne (severe) ( 24927181) Restless legs syndrome ( 29029846) Smoking status (ever vs never smokers) ( 30643258)	Alanine aminotransferase levels ( 34315874) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Aspartate aminotransferase levels ( 34315874) Autoimmune thyroid disease ( 32581359) Cognitive decline rate in late mild cognitive impairment ( 26252872) Daytime sleep phenotypes ( 27126917) Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Neutrophil percentage of white cells ( 32888494) White blood cell count ( 32888494)
Interacting Genes		46 interacting genes: APPBP2 AQP2 AQP6 AQP9 ARL13B CD79A CFTR CLDN5 CX3CR1 EBP ELOVL4 ERGIC3 FAM174A FAM210B FFAR2 FOXP1 GJA8 GLP1R GOLT1A GPR152 GPR42 GPX8 HSD17B13 MS4A3 MTNR1A MUC1 NIPA1 OPRM1 RETREG3 SCN3B SERINC2 SLC10A6 SLC18A3 SLC35H1 SLC7A14 SYT2 TACR1 TLCD4 TM4SF19 TMEM179B TMEM237 TMEM51 TMEM80 TMEM86B TMX2 VKORC1	2 interacting genes: CCDC167 CX3CL1
Entrez ID		154467	1524
HPRD ID		18561	03277
Ensembl ID		ENSG00000198937	ENSG00000168329
Uniprot IDs		Q9P0B6	P49238
PDB IDs			7XBW 7XBX
Enriched GO Terms of Interacting Partners?		Membrane Water Transport Fluid Transport Transmembrane Transport Water Channel Activity G Protein-coupled Receptor Activity Plasma Membrane Organic Hydroxy Compound Transport Glycerol Transmembrane Transport G Protein-coupled Peptide Receptor Activity Positive Regulation Of Synaptic Transmission, Cholinergic Channel Activity Renal Water Transport Protein Binding Polyol Transmembrane Transport Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Endoplasmic Reticulum	Leukocyte Adhesive Activation Negative Regulation Of Interleukin-1 Alpha Production CXCR1 Chemokine Receptor Binding Positive Regulation Of Calcium-independent Cell-cell Adhesion Negative Regulation Of Glutamate Receptor Signaling Pathway CX3C Chemokine Receptor Binding Negative Regulation Of Hippocampal Neuron Apoptotic Process Integrin Activation Microglial Cell Proliferation Negative Regulation Of Microglial Cell Activation Autocrine Signaling Positive Regulation Of Glial Cell Migration Regulation Of Microglial Cell Migration Negative Regulation Of Neuron Migration Positive Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Microglial Cell Migration Regulation Of Glutamate Receptor Signaling Pathway Synapse Pruning Regulation Of Hippocampal Neuron Apoptotic Process Neuron Remodeling Macrophage Chemotaxis Angiogenesis Involved In Wound Healing Negative Regulation Of Macrophage Activation Negative Regulation Of Neuroinflammatory Response Regulation Of Microglial Cell Activation Positive Regulation Of Transforming Growth Factor Beta Production Leukocyte Migration Involved In Inflammatory Response Eosinophil Migration Eosinophil Chemotaxis Regulation Of Glial Cell Migration Macrophage Migration Lymphocyte Chemotaxis Glial Cell Proliferation Positive Regulation Of Macrophage Migration CCR Chemokine Receptor Binding Positive Regulation Of Neuroblast Proliferation Regulation Of Lipopolysaccharide-mediated Signaling Pathway Neuron Maturation Microglial Cell Activation Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Chemoattractant Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Interleukin-1 Beta Production Leukocyte Activation Involved In Inflammatory Response Negative Regulation Of Interleukin-1 Production Regulation Of Neuroinflammatory Response Regulation Of Neuroblast Proliferation Positive Chemotaxis Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
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