IL10RB and IL10RA

Number of citations of the paper that reports this interaction (PubMedID 9312047)
49

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		IL10RB	IL10RA
Description		interleukin 10 receptor subunit beta	interleukin 10 receptor subunit alpha
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GO Annotations	Cellular Component	Plasma Membrane Membrane Interleukin-28 Receptor Complex	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cilium Membrane Apical Plasma Membrane
	Molecular Function	Interleukin-10 Receptor Activity Protein Binding Coreceptor Activity Signaling Receptor Activity	Interleukin-10 Receptor Activity Protein Binding Interleukin-10 Binding Signaling Receptor Activity
	Biological Process	Inflammatory Response Immune Response Signal Transduction Cytokine-mediated Signaling Pathway Type III Interferon-mediated Signaling Pathway Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Defense Response To Virus Cellular Response To Virus Interleukin-10-mediated Signaling Pathway Positive Regulation Of Cellular Respiration	Negative Regulation Of Autophagy Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Inflammatory Response Regulation Of Synapse Organization Intestinal Epithelial Structure Maintenance Ubiquitin-dependent Endocytosis Interleukin-10-mediated Signaling Pathway
Pathways		Other interleukin signaling Interleukin-10 signaling Interleukin-20 family signaling	Interleukin-10 signaling Nuclear events stimulated by ALK signaling in cancer
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) COVID-19 ( 33949668) Crohn's disease ( 23128233) Multiple sclerosis ( 31604244) Narcolepsy ( 23459209 24204295)	Obesity-related traits ( 23251661)
Interacting Genes		7 interacting genes: IFNL2 IFNL3 IL10 IL10RA IL22 UCN2 UCN3	20 interacting genes: BTRC C1QL4 CDS2 CMTM3 HACD1 IL10 IL10RB JAK1 MAL NIPAL4 PLPP6 RUSF1 SELENOK SLC38A7 SLC66A2 SLC7A14 SMCO4 TMEM242 TMUB2 YIPF6
Entrez ID		3588	3587
HPRD ID		00473	00911
Ensembl ID		ENSG00000243646	ENSG00000110324
Uniprot IDs		A0A1B0GTI5 A0A1B0GU52 Q08334	Q13651
PDB IDs		3LQM 5T5W 6X93 9BPU 9BPV	1J7V 1LQS 1Y6K 1Y6M 1Y6N 5IXI 6X93
Enriched GO Terms of Interacting Partners?		Corticotropin-releasing Hormone Receptor Binding Extracellular Space Corticotropin-releasing Hormone Receptor 2 Binding Cytokine Activity Interleukin-10-mediated Signaling Pathway Type III Interferon-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Response To Glucocorticoid Signaling Receptor Binding Response To Corticosteroid Signal Transduction Negative Regulation Of Inflammatory Response Digestion Response To Steroid Hormone Response To Hormone Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Extracellular Region Positive Regulation Of Receptor Signaling Pathway Via STAT Negative Regulation Of Defense Response Interleukin-10 Receptor Binding Negative Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Response To Lipid Negative Regulation Of Cytokine Activity Interleukin-10 Binding Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Receptor Signaling Pathway Via JAK-STAT Interferon-mediated Signaling Pathway Cellular Response To Virus Cell Surface Receptor Signaling Pathway Via STAT Chronic Inflammatory Response To Antigenic Stimulus Negative Regulation Of Interleukin-18 Production Regulation Of Cytokine Activity Interleukin-10 Receptor Activity Interleukin-22 Receptor Binding Regulation Of Inflammatory Response Negative Regulation Of Autophagy Response To Carbon Monoxide Hormone Activity NADPH Dehydrogenase (quinone) Activity Response To Stress Negative Regulation Of Chronic Inflammatory Response Negative Regulation Of Receptor Binding Negative Regulation Of Myeloid Dendritic Cell Activation Positive Regulation Of B Cell Apoptotic Process Negative Regulation Of Interferon-alpha Production Positive Regulation Of Plasma Cell Differentiation 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) Activity Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity Negative Regulation Of MHC Class II Biosynthetic Process Hormone-mediated Signaling Pathway	Interleukin-10-mediated Signaling Pathway Membrane Response To Inactivity Type III Interferon-mediated Signaling Pathway
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