IL10RB and UCN3

Number of citations of the paper that reports this interaction (PMID 11416224)
149

Data Source:
HPRD (in vitro)

		IL10RB	UCN3
Gene Name		interleukin 10 receptor, beta	urocortin 3
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Interleukin-28 Receptor Complex Extracellular Vesicular Exosome	Extracellular Space Varicosity Axon Terminus
	Molecular Function	Receptor Activity Interleukin-10 Receptor Activity Protein Binding	G-protein Coupled Receptor Binding Hormone Activity Corticotropin-releasing Hormone Receptor 2 Binding
	Biological Process	Inflammatory Response Immune Response Signal Transduction Cytokine-mediated Signaling Pathway Defense Response To Virus	Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Digestion Response To Glucose Cellular Response To Nutrient Levels Positive Regulation Of Insulin Secretion Response To Immobilization Stress Response To Starvation Positive Regulation Of Membrane Potential Response To Corticosterone Cellular Response To Hypoxia
Pathways
Drugs
Diseases
GWAS		Crohn's disease ( 23128233)	Intelligence ( 22449649)
Protein-Protein Interactions		7 interactors: IFNL2 IFNL3 IL10 IL10RA IL22 UCN2 UCN3	3 interactors: CRHR1 CRHR2 IL10RB
Entrez ID		3588	114131
HPRD ID		00473	12066
Ensembl ID		ENSG00000243646	ENSG00000178473
Uniprot IDs		Q08334	Q969E3
PDB IDs		3LQM	2RMH 3N93
Enriched GO Terms of Interacting Partners?		Response To Glucocorticoid Response To Corticosteroid Response To Lipid Response To External Stimulus Response To Steroid Hormone Response To Immobilization Stress Response To Other Organism Response To Biotic Stimulus Signaling Cell Communication Response To Stress Response To Organic Cyclic Compound Response To Hormone JAK-STAT Cascade Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Response To Organic Substance Negative Regulation Of Interferon-alpha Biosynthetic Process Negative Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Defense Response Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Digestion Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Response To Stimulus Regulation Of Secretion G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Defense Response To Virus Negative Regulation Of Secretion By Cell Negative Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Luteinizing Hormone Secretion Response To Carbon Monoxide Negative Regulation Of Myeloid Dendritic Cell Activation Negative Regulation Of Secretion Cellular Response To Nutrient Levels Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Protein Secretion Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of B Cell Apoptotic Process Regulation Of Immune Response Cellular Response To Extracellular Stimulus Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of MHC Class II Biosynthetic Process Regulation Of Myeloid Dendritic Cell Activation Receptor Biosynthetic Process Cytoplasmic Sequestering Of NF-kappaB Negative Regulation Of Chronic Inflammatory Response Negative Regulation Of Gonadotropin Secretion Negative Regulation Of Cytokine Secretion Involved In Immune Response	Cellular Response To Corticotropin-releasing Hormone Stimulus Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger General Adaptation Syndrome, Behavioral Process Corticotropin Secretion General Adaptation Syndrome Cellular Response To Organic Substance Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Regulation Of Corticosterone Secretion Negative Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Epinephrine Secretion Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Feeding Behavior Negative Regulation Of CAMP-mediated Signaling Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Response To Organic Substance Locomotory Exploration Behavior Behavioral Response To Ethanol Positive Regulation Of Mast Cell Degranulation Regulation Of Feeding Behavior Positive Regulation Of CAMP-mediated Signaling Behavioral Response To Cocaine Positive Regulation Of Mast Cell Activation Cellular Response To Hormone Stimulus Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Parturition Cell Surface Receptor Signaling Pathway Negative Regulation Of Cation Channel Activity Positive Regulation Of Regulated Secretory Pathway Regulation Of Voltage-gated Calcium Channel Activity Behavioral Response To Pain Regulation Of CAMP-mediated Signaling Response To Immobilization Stress Hypothalamus Development Regulation Of Mast Cell Degranulation Exploration Behavior Response To Organonitrogen Compound Activation Of Adenylate Cyclase Activity Positive Regulation Of Adenylate Cyclase Activity Regulation Of Mast Cell Activation Response To Hormone Regulation Of Regulated Secretory Pathway Adrenal Gland Development Response To Pain Fear Response Negative Regulation Of Transporter Activity
Tagcloud ?		bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il11ra il3ra il6st lifr lymphatic microarrays myl9 mylk myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify	agonists belonging cardioprotection cardiovascular congestive corticotropin crh exert gastrointestinal gpcr hormones inotropic lusitropic nervous r1 r2 releasing renin reperfusion reproductive restoration summarizes suppress sympathetic ucn1 ucn2 urocortins vasodilation
Tagcloud (Difference) ?		bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il11ra il3ra il6st lifr lymphatic microarrays myl9 mylk myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify	agonists belonging cardioprotection cardiovascular congestive corticotropin crh exert gastrointestinal gpcr hormones inotropic lusitropic nervous r1 r2 releasing renin reperfusion reproductive restoration summarizes suppress sympathetic ucn1 ucn2 urocortins vasodilation
Tagcloud (Intersection) ?