IL10RA and IL10RB

Number of citations of the paper that reports this interaction (PMID 9312047)
50

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		IL10RA	IL10RB
Gene Name		interleukin 10 receptor, alpha	interleukin 10 receptor, beta
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Plasma Membrane Integral Component Of Membrane Interleukin-28 Receptor Complex Extracellular Vesicular Exosome
	Molecular Function	Signal Transducer Activity Receptor Activity Interleukin-10 Receptor Activity Protein Binding Interleukin-10 Binding	Receptor Activity Interleukin-10 Receptor Activity Protein Binding
	Biological Process	Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide	Inflammatory Response Immune Response Signal Transduction Cytokine-mediated Signaling Pathway Defense Response To Virus
Pathways
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Crohn's disease ( 23128233)
Protein-Protein Interactions		3 interactors: IL10 IL10RB JAK1	7 interactors: IFNL2 IFNL3 IL10 IL10RA IL22 UCN2 UCN3
Entrez ID		3587	3588
HPRD ID		00911	00473
Ensembl ID		ENSG00000110324	ENSG00000243646
Uniprot IDs		Q13651	Q08334
PDB IDs		1J7V 1LQS 1Y6K 1Y6M 1Y6N	3LQM
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Interferon-alpha Biosynthetic Process Negative Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Immune Response Defense Response Interleukin-2-mediated Signaling Pathway Response To Carbon Monoxide Negative Regulation Of Myeloid Dendritic Cell Activation Cellular Response To Organic Substance Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of B Cell Apoptotic Process Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of MHC Class II Biosynthetic Process Regulation Of Myeloid Dendritic Cell Activation Immune System Process Receptor Biosynthetic Process Cytoplasmic Sequestering Of NF-kappaB Negative Regulation Of Chronic Inflammatory Response Negative Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of MHC Class II Biosynthetic Process Inflammatory Response Cytokine-mediated Signaling Pathway Type 2 Immune Response Response To Organic Substance Response To Interleukin-2 Branching Involved In Labyrinthine Layer Morphogenesis Response To Inactivity Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Cytokine Secretion Involved In Immune Response Regulation Of Chronic Inflammatory Response Cellular Response To Cytokine Stimulus Negative Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of B Cell Proliferation Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of NF-kappaB Import Into Nucleus Regulation Of B Cell Apoptotic Process Regulation Of Tumor Necrosis Factor Biosynthetic Process Cellular Response To Estradiol Stimulus Positive Regulation Of Lymphocyte Apoptotic Process Response To Cytokine Response To Other Organism Negative Regulation Of Interleukin-12 Production Cytoplasmic Sequestering Of Transcription Factor Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Labyrinthine Layer Morphogenesis Response To Biotic Stimulus Cytoplasmic Sequestering Of Protein Response To Stress Regulation Of Sensory Perception Of Pain Negative Regulation Of Growth Of Symbiont In Host	Response To Glucocorticoid Response To Corticosteroid Response To Lipid Response To External Stimulus Response To Steroid Hormone Response To Immobilization Stress Response To Other Organism Response To Biotic Stimulus Signaling Cell Communication Response To Stress Response To Organic Cyclic Compound Response To Hormone JAK-STAT Cascade Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Response To Organic Substance Negative Regulation Of Interferon-alpha Biosynthetic Process Negative Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Defense Response Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Digestion Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Response To Stimulus Regulation Of Secretion G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Defense Response To Virus Negative Regulation Of Secretion By Cell Negative Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Luteinizing Hormone Secretion Response To Carbon Monoxide Negative Regulation Of Myeloid Dendritic Cell Activation Negative Regulation Of Secretion Cellular Response To Nutrient Levels Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Protein Secretion Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of B Cell Apoptotic Process Regulation Of Immune Response Cellular Response To Extracellular Stimulus Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of MHC Class II Biosynthetic Process Regulation Of Myeloid Dendritic Cell Activation Receptor Biosynthetic Process Cytoplasmic Sequestering Of NF-kappaB Negative Regulation Of Chronic Inflammatory Response Negative Regulation Of Gonadotropin Secretion Negative Regulation Of Cytokine Secretion Involved In Immune Response
Tagcloud ?		bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il3ra il6st lifr lymphatic microarrays myl9 mylk myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify	bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il11ra il3ra il6st lifr lymphatic microarrays myl9 mylk myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il11ra il3ra il6st lifr lymphatic microarrays myl9 mylk myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify