IL10RA and HACD1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		IL10RA	HACD1
Description		interleukin 10 receptor subunit alpha	3-hydroxyacyl-CoA dehydratase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cilium Membrane Apical Plasma Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Interleukin-10 Receptor Activity Protein Binding Interleukin-10 Binding Signaling Receptor Activity	Protein Binding Lyase Activity 3-hydroxyacyl-CoA Dehydratase Activity Enzyme Binding Hydroxyapatite Binding Very-long-chain (3R)-3-hydroxyacyl-CoA Dehydratase Activity
	Biological Process	Negative Regulation Of Autophagy Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Inflammatory Response Regulation Of Synapse Organization Intestinal Epithelial Structure Maintenance Ubiquitin-dependent Endocytosis Interleukin-10-mediated Signaling Pathway	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Positive Regulation Of Cell-substrate Adhesion Sphingolipid Biosynthetic Process Fatty Acid Elongation Long-chain Fatty-acyl-CoA Biosynthetic Process Very Long-chain Fatty Acid Biosynthetic Process Protein-containing Complex Assembly Cementum Mineralization
Pathways		Interleukin-10 signaling Nuclear events stimulated by ALK signaling in cancer	Synthesis of very long-chain fatty acyl-CoAs
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Interacting Genes		20 interacting genes: BTRC C1QL4 CDS2 CMTM3 HACD1 IL10 IL10RB JAK1 MAL NIPAL4 PLPP6 RUSF1 SELENOK SLC38A7 SLC66A2 SLC7A14 SMCO4 TMEM242 TMUB2 YIPF6	7 interacting genes: CPLX4 IL10RA LMNA RNF170 TECR TMEM106C UBC
Entrez ID		3587	9200
HPRD ID		00911	10175
Ensembl ID		ENSG00000110324	ENSG00000165996
Uniprot IDs		Q13651	B0YJ81
PDB IDs		1J7V 1LQS 1Y6K 1Y6M 1Y6N 5IXI 6X93
Enriched GO Terms of Interacting Partners?		Interleukin-10-mediated Signaling Pathway Membrane Response To Inactivity Type III Interferon-mediated Signaling Pathway	Regulation Of Cellular Response To X-ray Negative Regulation Of Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Involved In Ureteric Bud Formation Type IV Hypersensitivity Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Ureteric Bud Formation Negative Regulation Of Cell Proliferation Involved In Mesonephros Development Interleukin-10 Binding Pro-T Cell Differentiation Parathyroid Hormone Secretion Interleukin-10 Receptor Activity DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Endoplasmic Reticulum Membrane Very-long-chain Enoyl-CoA Reductase Activity
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