IL10RB and IFNL3

Number of citations of the paper that reports this interaction (PMID 12469119)
211

Data Source:
HPRD (in vivo)

		IL10RB	IFNL3
Gene Name		interleukin 10 receptor, beta	interferon, lambda 3
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Interleukin-28 Receptor Complex Extracellular Vesicular Exosome	Extracellular Space
	Molecular Function	Receptor Activity Interleukin-10 Receptor Activity Protein Binding	Cytokine Activity
	Biological Process	Inflammatory Response Immune Response Signal Transduction Cytokine-mediated Signaling Pathway Defense Response To Virus	JAK-STAT Cascade Negative Regulation Of Viral Genome Replication Positive Regulation Of Immune Response Defense Response To Virus
Pathways
Drugs
Diseases
GWAS		Crohn's disease ( 23128233)
Protein-Protein Interactions		7 interactors: IFNL2 IFNL3 IL10 IL10RA IL22 UCN2 UCN3	1 interactors: IL10RB
Entrez ID		3588	282617
HPRD ID		00473	09587
Ensembl ID		ENSG00000243646	ENSG00000197110
Uniprot IDs		Q08334	Q8IZI9
PDB IDs		3LQM	3HHC
Enriched GO Terms of Interacting Partners?		Response To Glucocorticoid Response To Corticosteroid Response To Lipid Response To External Stimulus Response To Steroid Hormone Response To Immobilization Stress Response To Other Organism Response To Biotic Stimulus Signaling Cell Communication Response To Stress Response To Organic Cyclic Compound Response To Hormone JAK-STAT Cascade Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Response To Organic Substance Negative Regulation Of Interferon-alpha Biosynthetic Process Negative Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Defense Response Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Digestion Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Response To Stimulus Regulation Of Secretion G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Defense Response To Virus Negative Regulation Of Secretion By Cell Negative Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Luteinizing Hormone Secretion Response To Carbon Monoxide Negative Regulation Of Myeloid Dendritic Cell Activation Negative Regulation Of Secretion Cellular Response To Nutrient Levels Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Protein Secretion Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of B Cell Apoptotic Process Regulation Of Immune Response Cellular Response To Extracellular Stimulus Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of MHC Class II Biosynthetic Process Regulation Of Myeloid Dendritic Cell Activation Receptor Biosynthetic Process Cytoplasmic Sequestering Of NF-kappaB Negative Regulation Of Chronic Inflammatory Response Negative Regulation Of Gonadotropin Secretion Negative Regulation Of Cytokine Secretion Involved In Immune Response
Tagcloud ?		bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il11ra il3ra il6st lifr lymphatic microarrays myl9 mylk myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify	accounting arising atypical autonomous clearance deltag flaviviridae hcv hepatocytes heterozygous ifnl4 inefficiently isoform lambda3 load maladaptive nevertheless phhs potency rs368234815 secreted surrounding sustained termed transcript tt upstream virological
Tagcloud (Difference) ?		bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il11ra il3ra il6st lifr lymphatic microarrays myl9 mylk myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify	accounting arising atypical autonomous clearance deltag flaviviridae hcv hepatocytes heterozygous ifnl4 inefficiently isoform lambda3 load maladaptive nevertheless phhs potency rs368234815 secreted surrounding sustained termed transcript tt upstream virological
Tagcloud (Intersection) ?