IL10RB and UCN2

Number of citations of the paper that reports this interaction (PubMedID 11416224)
40

Data Source:
HPRD (in vitro)

		IL10RB	UCN2
Description		interleukin 10 receptor subunit beta	urocortin 2
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GO Annotations	Cellular Component	Plasma Membrane Membrane Interleukin-28 Receptor Complex	Extracellular Region Extracellular Space
	Molecular Function	Interleukin-10 Receptor Activity Protein Binding Coreceptor Activity Signaling Receptor Activity	G Protein-coupled Receptor Binding Signaling Receptor Binding Hormone Activity Hormone Binding Corticotropin-releasing Hormone Receptor Binding Corticotropin-releasing Hormone Receptor 2 Binding
	Biological Process	Inflammatory Response Immune Response Signal Transduction Cytokine-mediated Signaling Pathway Type III Interferon-mediated Signaling Pathway Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Defense Response To Virus Cellular Response To Virus Interleukin-10-mediated Signaling Pathway Positive Regulation Of Cellular Respiration	Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Digestion Hormone-mediated Signaling Pathway Cellular Response To Nutrient Levels
Pathways		Other interleukin signaling Interleukin-10 signaling Interleukin-20 family signaling	Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) COVID-19 ( 33949668) Crohn's disease ( 23128233) Multiple sclerosis ( 31604244) Narcolepsy ( 23459209 24204295)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 25082827 28067908)
Interacting Genes		7 interacting genes: IFNL2 IFNL3 IL10 IL10RA IL22 UCN2 UCN3	2 interacting genes: CRHR2 IL10RB
Entrez ID		3588	90226
HPRD ID		00473	16171
Ensembl ID		ENSG00000243646	ENSG00000145040
Uniprot IDs		A0A1B0GTI5 A0A1B0GU52 Q08334	Q96RP3
PDB IDs		3LQM 5T5W 6X93 9BPU 9BPV	2RMG 3N95
Enriched GO Terms of Interacting Partners?		Corticotropin-releasing Hormone Receptor Binding Extracellular Space Corticotropin-releasing Hormone Receptor 2 Binding Cytokine Activity Interleukin-10-mediated Signaling Pathway Type III Interferon-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Response To Glucocorticoid Signaling Receptor Binding Response To Corticosteroid Signal Transduction Negative Regulation Of Inflammatory Response Digestion Response To Steroid Hormone Response To Hormone Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Extracellular Region Positive Regulation Of Receptor Signaling Pathway Via STAT Negative Regulation Of Defense Response Interleukin-10 Receptor Binding Negative Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Response To Lipid Negative Regulation Of Cytokine Activity Interleukin-10 Binding Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Receptor Signaling Pathway Via JAK-STAT Interferon-mediated Signaling Pathway Cellular Response To Virus Cell Surface Receptor Signaling Pathway Via STAT Chronic Inflammatory Response To Antigenic Stimulus Negative Regulation Of Interleukin-18 Production Regulation Of Cytokine Activity Interleukin-10 Receptor Activity Interleukin-22 Receptor Binding Regulation Of Inflammatory Response Negative Regulation Of Autophagy Response To Carbon Monoxide Hormone Activity NADPH Dehydrogenase (quinone) Activity Response To Stress Negative Regulation Of Chronic Inflammatory Response Negative Regulation Of Receptor Binding Negative Regulation Of Myeloid Dendritic Cell Activation Positive Regulation Of B Cell Apoptotic Process Negative Regulation Of Interferon-alpha Production Positive Regulation Of Plasma Cell Differentiation 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) Activity Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity Negative Regulation Of MHC Class II Biosynthetic Process Hormone-mediated Signaling Pathway	Corticotropin-releasing Hormone Receptor Activity Corticotrophin-releasing Factor Receptor Activity Interleukin-10 Receptor Activity Interleukin-28 Receptor Complex Cellular Response To Corticotropin-releasing Hormone Stimulus Type III Interferon-mediated Signaling Pathway Interleukin-10-mediated Signaling Pathway Positive Regulation Of Cellular Respiration G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Cellular Respiration Positive Regulation Of Receptor Signaling Pathway Via STAT Long-term Synaptic Potentiation Axon Terminus Coreceptor Activity Cellular Response To Virus Interferon-mediated Signaling Pathway Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Surface Receptor Signaling Pathway
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