IL9R and IL2RG

Number of citations of the paper that reports this interaction (PubMedID 11418623)
0

Data Source:
HPRD (in vivo)

		IL9R	IL2RG
Description		interleukin 9 receptor	interleukin 2 receptor subunit gamma
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane External Side Of Plasma Membrane Membrane	Nucleoplasm Endosome Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Receptor Complex
	Molecular Function	Cytokine Receptor Activity Interleukin-9 Receptor Activity Interleukin-9 Binding	Cytokine Receptor Activity Interleukin-2 Receptor Activity Interleukin-4 Receptor Activity Interleukin-7 Receptor Activity Protein Binding Coreceptor Activity Cytokine Binding Interleukin-2 Binding Interleukin-15 Receptor Activity
	Biological Process	Signal Transduction Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Regulation Of Cell Population Proliferation	Mature B Cell Differentiation CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Immune System Process Positive Regulation Of Immunoglobulin Production Immune Response Signal Transduction Gene Expression Regulation Of Gene Expression Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Cellular Homeostasis Lymphocyte Differentiation B Cell Differentiation Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation T Cell Differentiation In Thymus Positive Regulation Of T Cell Differentiation In Thymus Interleukin-15-mediated Signaling Pathway Interleukin-4-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Positive Regulation Of B Cell Differentiation Positive Regulation Of Phagocytosis
Pathways		Interleukin-9 signaling	Interleukin-7 signaling Interleukin-7 signaling RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-9 signaling Interleukin-2 signaling Interleukin-21 signaling Interleukin receptor SHC signaling STAT3 nuclear events downstream of ALK signaling
Drugs			Denileukin diftitox Aldesleukin Resatorvid
Diseases			T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS
Interacting Genes		6 interacting genes: CRADD IL2RG IL9 JAK1 KAT5 YWHAZ	27 interacting genes: AXL CAPNS1 ERRFI1 ICAM1 IL15 IL15RA IL2 IL2RB IL4 IL4R IL7 IL7R IL9R JAK1 JAK3 KRTAP10-3 KRTAP10-8 KRTAP5-7 NOTCH2NLA PTPRJ SHB SHC1 STAT1 STAT5A STK4 WWP1 WWP2
Entrez ID		3581	3561
HPRD ID		02052	02391
Ensembl ID		ENSG00000124334	ENSG00000147168
Uniprot IDs		Q01113	H0Y8J6 P31785
PDB IDs		7OX5	2B5I 2ERJ 3BPL 3QAZ 3QB7 4GS7 5M5E 6OEL 7S2R 8ENT 8EPA 9JQT
Enriched GO Terms of Interacting Partners?		Interleukin-9-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-4-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Positive Regulation Of Regulatory T Cell Differentiation Regulation Of Regulatory T Cell Differentiation Cellular Response To Glucose Starvation DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Cell-cell Adhesion Signal Transduction Cytokine-mediated Signaling Pathway Immune Response Interleukin-9 Receptor Binding Histone H2AK5 Acetyltransferase Activity B Cell Differentiation Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Interleukin-4 Receptor Activity Interleukin-7 Receptor Activity Protein Phosphatase Binding Synaptic Target Recognition Signal Transduction By P53 Class Mediator Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Peptide Crotonyltransferase Activity Positive Regulation Of T Cell Differentiation Positive Regulation Of Lymphocyte Differentiation Interleukin-2 Binding Interleukin-2 Receptor Activity Interleukin-15 Receptor Activity Death Domain Binding Endopeptidase Complex Histone H2A Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Positive Regulation Of Multicellular Organismal Process Signal Transduction In Response To DNA Damage Regulation Of Protein Localization To Nucleus CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Piccolo Histone Acetyltransferase Complex Intracellular Signal Transduction Regulation Of Cell Adhesion Receptor Complex B Cell Activation Positive Regulation Of Leukocyte Differentiation Immune System Process Regulation Of T Cell Differentiation Cellular Response To Starvation Golgi Reassembly DNA-binding Transcription Factor Binding	Cytokine-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Positive Regulation Of Lymphocyte Differentiation Regulation Of Lymphocyte Differentiation Lymphocyte Activation Cell Surface Receptor Signaling Pathway Interleukin-4-mediated Signaling Pathway Positive Regulation Of Leukocyte Differentiation Interleukin-9-mediated Signaling Pathway Leukocyte Activation Regulation Of Hemopoiesis Lymphocyte Differentiation Cell Activation Interleukin-2-mediated Signaling Pathway Positive Regulation Of Cell Activation Regulation Of T Cell Differentiation Cell Surface Receptor Signaling Pathway Via STAT Mononuclear Cell Differentiation Positive Regulation Of Lymphocyte Activation Regulation Of Cell Activation Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Leukocyte Differentiation Regulation Of Multicellular Organismal Development Positive Regulation Of Cell Development Positive Regulation Of T Cell Differentiation Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Adhesion Positive Regulation Of Natural Killer Cell Differentiation Positive Regulation Of Cell-cell Adhesion Regulation Of Cell Development Positive Regulation Of Cell Differentiation Regulation Of Cell-cell Adhesion Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of T Cell Activation Regulation Of Natural Killer Cell Differentiation Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Signal Transduction Cytokine Receptor Activity Regulation Of T-helper Cell Differentiation Positive Regulation Of Immune System Process B Cell Activation Regulation Of Cell Differentiation Regulation Of Cytokine Production Immune System Process Natural Killer Cell Differentiation Regulation Of Immune System Process Natural Killer Cell Activation
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