IL9R and CRADD

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		IL9R	CRADD
Description		interleukin 9 receptor	CARD and death domain containing adaptor protein
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane External Side Of Plasma Membrane Membrane	Nucleus Nucleolus Cytoplasm Cytosol Endopeptidase Complex
	Molecular Function	Cytokine Receptor Activity Interleukin-9 Receptor Activity Interleukin-9 Binding	Protease Binding Protein Binding Protein-macromolecule Adaptor Activity Death Domain Binding
	Biological Process	Signal Transduction Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Regulation Of Cell Population Proliferation	Apoptotic Process DNA Damage Response Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Interleukin-9 signaling	TP53 Regulates Transcription of Caspase Activators and Caspases
Drugs
Diseases
GWAS			Alzheimer's disease (cognitive decline) ( 23535033) Appendicular lean mass ( 33097823) Asthma ( 31959851) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heel bone mineral density ( 28869591 30598549) Height ( 31562340 33713608 18391951 31217584 28552196 25282103) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 25673412 34021172) Lung function (FVC) ( 30804560 30061609) Pulse pressure ( 27841878) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Reticulocyte count ( 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		6 interacting genes: CRADD IL2RG IL9 JAK1 KAT5 YWHAZ	22 interacting genes: ACTN2 APP APPL2 BBS5 CASP2 CASP8 CCSER2 DCXR EEF1A1 ERG28 IL9R KCTD9 KPNA1 LRIF1 PIDD1 PTGER4 RIPK1 SLC35A3 TRIM54 TSHR VTN WIF1
Entrez ID		3581	8738
HPRD ID		02052	04584
Ensembl ID		ENSG00000124334	ENSG00000169372
Uniprot IDs		Q01113	B4DJT6 F5H7C2 F8VV49 F8VVY5 P78560 Q53XL1 Q8IY43
PDB IDs		7OX5	2O71 2OF5 3CRD
Enriched GO Terms of Interacting Partners?		Interleukin-9-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-4-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Positive Regulation Of Regulatory T Cell Differentiation Regulation Of Regulatory T Cell Differentiation Cellular Response To Glucose Starvation DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Cell-cell Adhesion Signal Transduction Cytokine-mediated Signaling Pathway Immune Response Interleukin-9 Receptor Binding Histone H2AK5 Acetyltransferase Activity B Cell Differentiation Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Interleukin-4 Receptor Activity Interleukin-7 Receptor Activity Protein Phosphatase Binding Synaptic Target Recognition Signal Transduction By P53 Class Mediator Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Peptide Crotonyltransferase Activity Positive Regulation Of T Cell Differentiation Positive Regulation Of Lymphocyte Differentiation Interleukin-2 Binding Interleukin-2 Receptor Activity Interleukin-15 Receptor Activity Death Domain Binding Endopeptidase Complex Histone H2A Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Positive Regulation Of Multicellular Organismal Process Signal Transduction In Response To DNA Damage Regulation Of Protein Localization To Nucleus CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Piccolo Histone Acetyltransferase Complex Intracellular Signal Transduction Regulation Of Cell Adhesion Receptor Complex B Cell Activation Positive Regulation Of Leukocyte Differentiation Immune System Process Regulation Of T Cell Differentiation Cellular Response To Starvation Golgi Reassembly DNA-binding Transcription Factor Binding	Positive Regulation Of Neuron Apoptotic Process Death Receptor Binding Endopeptidase Complex Extrinsic Apoptotic Signaling Pathway Signal Transduction Identical Protein Binding Ripoptosome Death-inducing Signaling Complex Positive Regulation Of Inflammatory Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Response To Mechanical Stimulus Cellular Response To Mechanical Stimulus Positive Regulation Of Macrophage Differentiation Negative Regulation Of Necroptotic Process Regulation Of Neuron Apoptotic Process Positive Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Programmed Necrotic Cell Death Cellular Response To Growth Factor Stimulus Execution Phase Of Apoptosis Regulation Of Macrophage Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Growth Factor Regulation Of Reactive Oxygen Species Metabolic Process Amyloid Fibril Formation Apoptotic Signaling Pathway Regulation Of Necroptotic Process Integrin Binding Actin Filament Uncapping Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Endocytosis Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Protein-containing Complex Binding Regulation Of Programmed Necrotic Cell Death Interleukin-9 Binding Interleukin-9 Receptor Activity Negative Regulation Of Eosinophil Extravasation Cellular Response To Thyrotropin-releasing Hormone Symbiont-containing Vacuole L-xylulose Reductase (NADPH) Activity Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Supramolecular Fiber Organization Regulation Of Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
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