CXCR2 and GRIA1

Number of citations of the paper that reports this interaction (PMID 12888558)
17

Data Source:
HPRD (in vivo)

		CXCR2	GRIA1
Gene Name		chemokine (C-X-C motif) receptor 2	glutamate receptor, ionotropic, AMPA 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Mast Cell Granule	Endoplasmic Reticulum Membrane Plasma Membrane Synaptic Vesicle Cell Surface Postsynaptic Density Cell Junction Dendrite Endocytic Vesicle Membrane Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Selective Glutamate Receptor Complex Dendrite Membrane Dendritic Spine Membrane Neuronal Cell Body Dendritic Spine Axonal Spine Neuron Spine Postsynaptic Membrane Recycling Endosome
	Molecular Function	Signal Transducer Activity Interleukin-8 Receptor Activity Protein Binding C-X-C Chemokine Receptor Activity Interleukin-8 Binding	Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Protein Binding Glutamate Receptor Activity PDZ Domain Binding
	Biological Process	Dendritic Cell Chemotaxis Acute Inflammatory Response To Antigenic Stimulus Chemotaxis Inflammatory Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Neutrophil Chemotaxis Midbrain Development Receptor Internalization Negative Regulation Of Neutrophil Apoptotic Process Interleukin-8-mediated Signaling Pathway Neutrophil Activation Positive Regulation Of Vascular Permeability Positive Regulation Of Angiogenesis Chemokine-mediated Signaling Pathway Metanephric Tubule Morphogenesis Positive Regulation Of Neutrophil Chemotaxis	Signal Transduction Synaptic Transmission Long-term Memory Receptor Internalization Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Long Term Synaptic Depression
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Trafficking of GluR2-containing AMPA receptors Activation of NMDA receptor upon glutamate binding and postsynaptic events Activation of AMPA receptors Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Transmission across Chemical Synapses
Drugs			L-Glutamic Acid Enflurane Isoflurane Methoxyflurane Desflurane Sevoflurane Perampanel
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Smooth-surface caries ( 23470693)	Aging (time to event) ( 21782286) Anthropometric traits ( 19260139) Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 20592726) Obesity-related traits ( 23251661) Sudden cardiac arrest ( 21658281)
Protein-Protein Interactions		21 interactors: ADRA1A ARRB1 CXCL1 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCR1 GNA14 GNA15 GNAI2 GNAI3 GPRASP1 GRIA1 MYO5B PPBP PPP2CA RAB11FIP2 RGS12 ST13	22 interactors: CACNG2 CAMK2G CANX CASP8 CXCR2 DLG1 EPB41L1 EPB41L2 GRIA4 GRID2 GRIK2 GRIP1 GRIPAP1 HOMER1 HSPA5 PICK1 PRKACA PRKCA SDCBP SQSTM1 TANC1 TRPC1
Entrez ID		3579	2890
HPRD ID		00907	00695
Ensembl ID		ENSG00000180871	ENSG00000155511
Uniprot IDs		P25025 Q53PC4	P42261 Q59GL5
PDB IDs
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Leukocyte Migration Cell Chemotaxis G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Behavior Regulation Of Chemotaxis Cell Surface Receptor Signaling Pathway Regulation Of Behavior Inflammatory Response Cytokine-mediated Signaling Pathway Signaling Cell Communication Response To Lipopolysaccharide Receptor Metabolic Process Positive Regulation Of Cell Migration Response To Molecule Of Bacterial Origin Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Platelet Activation Positive Regulation Of Locomotion Signal Transduction Regulation Of Body Fluid Levels Cellular Response To Cytokine Stimulus Chemotaxis Cellular Response To Stimulus Receptor Internalization Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Response To Cytokine Response To External Stimulus Response To Bacterium G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Migration Regulation Of Cell Migration Cell Motility Regulation Of Cell Motility Response To Stress Regulation Of Locomotion Cell Activation Blood Coagulation Cellular Response To Organic Substance Regulation Of Cellular Component Movement Hemostasis Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Response To Other Organism Response To Stimulus Regulation Of Cell Proliferation Response To Biotic Stimulus	Synaptic Transmission Cell-cell Signaling Signaling Cell Communication Response To External Stimulus Positive Regulation Of Macrophage Differentiation Glutamate Receptor Signaling Pathway Protein Localization Cortical Actin Cytoskeleton Organization Positive Regulation Of Dense Core Granule Biogenesis Developmental Process Cortical Cytoskeleton Organization Cell Differentiation Nervous System Development Histone H3-T6 Phosphorylation Positive Regulation Of Transport Cell Surface Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Negative Regulation Of Programmed Cell Death Neutrophil Chemotaxis Chemotaxis Anatomical Structure Development Apoptotic Signaling Pathway Receptor Clustering System Development Neutrophil Migration Positive Regulation Of Myeloid Leukocyte Differentiation Regulation Of Ion Transport Negative Regulation Of Cell Death Granulocyte Chemotaxis Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Anatomical Structure Morphogenesis Intrinsic Apoptotic Signaling Pathway Cell Activation Regulation Of Cellular Localization Regulation Of Apoptotic Process Regulation Of Calcium Ion Transport Cellular Metal Ion Homeostasis Neuron-neuron Synaptic Transmission Regulation Of Signaling Signal Transduction Dendritic Spine Maintenance Response To Cytokine Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Cell Death
Tagcloud ?		ab attenuating chemokine chemokines chemotactic cxcr1 defenses distress donors ena express fmlp functionally ligands migratory milieu neutrophil neutrophils observations offer oncogene persisted pmn polymorphonuclear preserving redundant sepsis septic	acutely arc camksmall cyrillicalpha dioxide durations environ gria2 grin1 grin2a grin2b implied inc inhalation inhaled lifelong m3 periodicals pka pollutant postsynaptic presynaptic psd so2 synapse synaptophysin toxicol ubiquitous wiley
Tagcloud (Difference) ?		ab attenuating chemokine chemokines chemotactic cxcr1 defenses distress donors ena express fmlp functionally ligands migratory milieu neutrophil neutrophils observations offer oncogene persisted pmn polymorphonuclear preserving redundant sepsis septic	acutely arc camksmall cyrillicalpha dioxide durations environ gria2 grin1 grin2a grin2b implied inc inhalation inhaled lifelong m3 periodicals pka pollutant postsynaptic presynaptic psd so2 synapse synaptophysin toxicol ubiquitous wiley
Tagcloud (Intersection) ?