CXCR2 and CLDN22

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CXCR2	CLDN22
Description		C-X-C motif chemokine receptor 2	claudin 22
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane External Side Of Plasma Membrane Cell Surface Microtubule Cytoskeleton Membrane Secretory Granule Membrane Mast Cell Granule Mitotic Spindle	Plasma Membrane Bicellular Tight Junction Membrane Anchoring Junction
	Molecular Function	Interleukin-8 Receptor Activity G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity C-C Chemokine Binding Interleukin-8 Binding	Structural Molecule Activity Protein Binding Identical Protein Binding
	Biological Process	Dendritic Cell Chemotaxis Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Population Proliferation Calcium-mediated Signaling Neutrophil Chemotaxis Receptor Internalization Interleukin-8-mediated Signaling Pathway Neutrophil Activation Negative Regulation Of Apoptotic Process Chemokine-mediated Signaling Pathway	Cell Adhesion Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Bicellular Tight Junction Assembly
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation	Tight junction interactions
Drugs
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 23128233 28067908) Lymphocyte percentage of white cells ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Neutrophil percentage of white cells ( 27863252 32888494) Smooth-surface caries ( 23470693) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252 32888494)
Interacting Genes		32 interacting genes: ADRA1A ARLN ARRB1 ATP13A1 CLDN22 CXCL1 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCR1 EMP1 FKBP8 GNA14 GNA15 GNAI2 GNAI3 GPRASP1 GRIA1 MYO5B PPBP PPP2CA RAB11FIP2 RGS12 SLC18A2 SLC39A2 SMCO4 ST13 TMEM147 TMEM80 TRARG1	7 interacting genes: CLEC4C CXCR2 LHFPL5 OPRM1 SPG21 TMBIM6 TREX1
Entrez ID		3579	53842
HPRD ID		00907	13068
Ensembl ID		ENSG00000180871	ENSG00000177300
Uniprot IDs		P25025 Q53PC4	Q8N7P3
PDB IDs		4Q3H 5TYT 6KVA 6KVF 6LFM 6LFO 8XVU 8XWA 8XWF 8XWM 8XWN 8XWS 8XWV 8XX3 8XX6 8XX7 8XXH 8XXR 8XXX
Enriched GO Terms of Interacting Partners?		Chemokine Activity Neutrophil Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Neutrophil Migration Cell Chemotaxis Granulocyte Chemotaxis CXCR Chemokine Receptor Binding Antimicrobial Humoral Response Granulocyte Migration Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Chemotaxis Cytokine Activity Myeloid Leukocyte Migration Locomotion Leukocyte Chemotaxis G Protein-coupled Receptor Binding Heterotrimeric G-protein Complex Humoral Immune Response G Protein-coupled Receptor Signaling Pathway Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Killing Of Cells Of Another Organism Leukocyte Migration Inflammatory Response Receptor Internalization Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Killing Signal Transduction Import Into Cell Signaling Endocytosis Negative Regulation Of Adenylate Cyclase Activity Cell Communication Cell Migration Calcium-mediated Signaling Cytoplasmic Vesicle Membrane GTPase Activity Receptor-mediated Endocytosis Cellular Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Defense Response To Symbiont Defense Response To Other Organism Cellular Response To Molecule Of Bacterial Origin Cell Motility G Protein-coupled Acetylcholine Receptor Signaling Pathway Cell-cell Signaling Response To Other Organism Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Vesicle-mediated Transport Plasma Membrane	Negative Regulation Of Cytosolic Calcium Ion Concentration Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Regulation Of Immunoglobulin Production Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Immune Complex Formation Adenyl Deoxyribonucleotide Binding Immune Response In Brain Or Nervous System Interleukin-8 Receptor Activity Secretory Granule Membrane Interleukin-8-mediated Signaling Pathway Endoribonuclease Inhibitor Activity Cellular Response To Type I Interferon DNA Exonuclease Activity Retrotransposition Transposition Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Interleukin-8 Binding Myeloid Leukocyte Activation Cellular Response To Morphine DNA Synthesis Involved In UV-damage Excision Repair Mast Cell Granule Membrane Regulation Of NMDA Receptor Activity System Process T Cell Antigen Processing And Presentation Negative Regulation Of Calcium Ion Transport Into Cytosol G Protein-coupled Opioid Receptor Activity Calcium Ion Transmembrane Transport Regulation Of Production Of Molecular Mediator Of Immune Response Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of IRE1-mediated Unfolded Protein Response MutSalpha Complex Binding Double-stranded DNA 3'-5' DNA Exonuclease Activity MutLalpha Complex Binding C-X-C Chemokine Receptor Activity Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Immune System Process Behavioral Response To Ethanol Calcium Ion Transport G Protein-coupled Opioid Receptor Signaling Pathway Nervous System Process IRE1-mediated Unfolded Protein Response 3'-5'-DNA Exonuclease Activity CD4 Receptor Binding Stereocilium Bundle Monoatomic Ion Transport Negative Regulation Of Immunoglobulin Production Cellular Response To Hydroxyurea
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