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CXCR2 and CXCL6
Number of citations of the paper that reports this interaction (PubMedID
10593335
)
0
Data Source:
HPRD
(in vivo)
CXCR2
CXCL6
Description
C-X-C motif chemokine receptor 2
C-X-C motif chemokine ligand 6
Image
GO Annotations
Cellular Component
Nucleoplasm
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Microtubule Cytoskeleton
Membrane
Secretory Granule Membrane
Mast Cell Granule
Mitotic Spindle
Extracellular Region
Extracellular Space
Molecular Function
Interleukin-8 Receptor Activity
G Protein-coupled Receptor Activity
Chemokine Receptor Activity
Protein Binding
C-C Chemokine Receptor Activity
C-X-C Chemokine Receptor Activity
C-C Chemokine Binding
Interleukin-8 Binding
Cytokine Activity
Protein Binding
Chemokine Activity
Heparin Binding
CXCR Chemokine Receptor Binding
Biological Process
Dendritic Cell Chemotaxis
Chemotaxis
Inflammatory Response
Immune Response
Cellular Defense Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Positive Regulation Of Cell Population Proliferation
Calcium-mediated Signaling
Neutrophil Chemotaxis
Receptor Internalization
Interleukin-8-mediated Signaling Pathway
Neutrophil Activation
Negative Regulation Of Apoptotic Process
Chemokine-mediated Signaling Pathway
Leukocyte Homeostasis
Chemotaxis
Defense Response
Inflammatory Response
Immune Response
Signal Transduction
Cell-cell Signaling
Neutrophil Chemotaxis
Response To Lipopolysaccharide
Regulation Of Chemokine Production
Neutrophil Activation
Defense Response To Bacterium
Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Chemokine-mediated Signaling Pathway
Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium
Cellular Response To Lipopolysaccharide
Antibacterial Innate Immune Response
Pathways
Chemokine receptors bind chemokines
G alpha (i) signalling events
Neutrophil degranulation
Chemokine receptors bind chemokines
G alpha (i) signalling events
Drugs
Diseases
GWAS
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Granulocyte count (
27863252
)
Granulocyte percentage of myeloid white cells (
27863252
)
Inflammatory bowel disease (
23128233
28067908
)
Lymphocyte percentage of white cells (
27863252
32888494
)
Monocyte percentage of white cells (
27863252
32888494
)
Myeloid white cell count (
27863252
)
Neutrophil count (
27863252
32888494
)
Neutrophil percentage of white cells (
27863252
32888494
)
Smooth-surface caries (
23470693
)
Sum basophil neutrophil counts (
27863252
)
Sum neutrophil eosinophil counts (
27863252
)
White blood cell count (
27863252
32888494
)
Basophil percentage of granulocytes (
27863252
)
Basophil percentage of white cells (
32888494
)
Blood protein levels in cardiovascular risk (
28369058
)
Eosinophil percentage of granulocytes (
27863252
)
Granulocyte count (
27863252
)
Granulocyte percentage of myeloid white cells (
27863252
)
Inflammatory bowel disease (
23128233
)
Lymphocyte percentage of white cells (
27863252
32888494
)
Monocyte percentage of white cells (
32888494
27863252
)
Myeloid white cell count (
27863252
)
Neonatal cytokine/chemokine levels (fetal genetic effect) (
30134952
)
Neutrophil count (
32888494
27863252
)
Neutrophil percentage of granulocytes (
27863252
)
Neutrophil percentage of white cells (
27863252
32888494
)
Sum basophil neutrophil counts (
27863252
)
Sum neutrophil eosinophil counts (
27863252
)
White blood cell count (
27863252
32888494
)
Interacting Genes
32 interacting genes:
ADRA1A
ARLN
ARRB1
ATP13A1
CLDN22
CXCL1
CXCL2
CXCL3
CXCL5
CXCL6
CXCL8
CXCR1
EMP1
FKBP8
GNA14
GNA15
GNAI2
GNAI3
GPRASP1
GRIA1
MYO5B
PPBP
PPP2CA
RAB11FIP2
RGS12
SLC18A2
SLC39A2
SMCO4
ST13
TMEM147
TMEM80
TRARG1
14 interacting genes:
CCL11
CCL5
CCL7
CCL8
CXCL1
CXCL10
CXCL12
CXCL2
CXCL3
CXCR1
CXCR2
MMP9
PF4
PPBP
Entrez ID
3579
6372
HPRD ID
00907
00735
Ensembl ID
ENSG00000180871
ENSG00000124875
Uniprot IDs
P25025
Q53PC4
P80162
PDB IDs
4Q3H
5TYT
6KVA
6KVF
6LFM
6LFO
8XVU
8XWA
8XWF
8XWM
8XWN
8XWS
8XWV
8XX3
8XX6
8XX7
8XXH
8XXR
8XXX
8XWM
8XXX
Enriched GO Terms of Interacting Partners
?
Chemokine Activity
Neutrophil Chemotaxis
Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Neutrophil Migration
Cell Chemotaxis
Granulocyte Chemotaxis
CXCR Chemokine Receptor Binding
Antimicrobial Humoral Response
Granulocyte Migration
Guanyl Nucleotide Binding
G-protein Beta/gamma-subunit Complex Binding
Chemotaxis
Cytokine Activity
Myeloid Leukocyte Migration
Locomotion
Leukocyte Chemotaxis
G Protein-coupled Receptor Binding
Heterotrimeric G-protein Complex
Humoral Immune Response
G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of G Protein-coupled Receptor Signaling Pathway
Killing Of Cells Of Another Organism
Leukocyte Migration
Inflammatory Response
Receptor Internalization
Regulation Of G Protein-coupled Receptor Signaling Pathway
Cell Killing
Signal Transduction
Import Into Cell
Signaling
Endocytosis
Negative Regulation Of Adenylate Cyclase Activity
Cell Communication
Cell Migration
Calcium-mediated Signaling
Cytoplasmic Vesicle Membrane
GTPase Activity
Receptor-mediated Endocytosis
Cellular Response To Lipopolysaccharide
Response To Molecule Of Bacterial Origin
Defense Response To Symbiont
Defense Response To Other Organism
Cellular Response To Molecule Of Bacterial Origin
Cell Motility
G Protein-coupled Acetylcholine Receptor Signaling Pathway
Cell-cell Signaling
Response To Other Organism
Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway
Vesicle-mediated Transport
Plasma Membrane
Chemokine Activity
Cell Chemotaxis
Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Chemotaxis
Locomotion
Granulocyte Chemotaxis
Leukocyte Chemotaxis
Granulocyte Migration
Antimicrobial Humoral Response
Cytokine Activity
Myeloid Leukocyte Migration
Leukocyte Migration
Cell Migration
Humoral Immune Response
Cell Motility
Killing Of Cells Of Another Organism
Chemokine-mediated Signaling Pathway
Cell Killing
Inflammatory Response
Immune Response
Defense Response To Symbiont
Defense Response To Other Organism
Mononuclear Cell Migration
Neutrophil Chemotaxis
Response To External Biotic Stimulus
Immune System Process
Defense Response
Cytokine-mediated Signaling Pathway
Neutrophil Migration
Extracellular Space
Response To Other Organism
G Protein-coupled Receptor Signaling Pathway
CXCR Chemokine Receptor Binding
Extracellular Region
Eosinophil Chemotaxis
Eosinophil Migration
Signal Transduction
CCR Chemokine Receptor Binding
Positive Regulation Of Lymphocyte Migration
Response To Stress
Positive Regulation Of Leukocyte Migration
Positive Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Regulation Of Lymphocyte Migration
Cell Surface Receptor Signaling Pathway
Intracellular Calcium Ion Homeostasis
Dendritic Cell Chemotaxis
Calcium Ion Homeostasis
Interleukin-8-mediated Signaling Pathway
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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