CXCR2 and CXCL2

Number of citations of the paper that reports this interaction (PubMedID 9260277)
41

Data Source:
HPRD (in vitro, in vivo)

		CXCR2	CXCL2
Description		C-X-C motif chemokine receptor 2	C-X-C motif chemokine ligand 2
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GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane External Side Of Plasma Membrane Cell Surface Microtubule Cytoskeleton Membrane Secretory Granule Membrane Mast Cell Granule Mitotic Spindle	Extracellular Region Extracellular Space
	Molecular Function	Interleukin-8 Receptor Activity G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity C-C Chemokine Binding Interleukin-8 Binding	Cytokine Activity Protein Binding Chemokine Activity
	Biological Process	Dendritic Cell Chemotaxis Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Population Proliferation Calcium-mediated Signaling Neutrophil Chemotaxis Receptor Internalization Interleukin-8-mediated Signaling Pathway Neutrophil Activation Negative Regulation Of Apoptotic Process Chemokine-mediated Signaling Pathway	Response To Molecule Of Bacterial Origin Chemotaxis Defense Response Inflammatory Response Immune Response Signal Transduction Killing Of Cells Of Another Organism Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation	Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 23128233 28067908) Lymphocyte percentage of white cells ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Neutrophil percentage of white cells ( 27863252 32888494) Smooth-surface caries ( 23470693) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252 32888494)	Basophil percentage of white cells ( 32888494) Eosinophil percentage of granulocytes ( 27863252) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 23128233) Lymphocyte percentage of white cells ( 27863252 32888494) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494 29403010) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 27863252 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494 29403010 27863252 21738479) White blood cell types ( 21738478)
Interacting Genes		32 interacting genes: ADRA1A ARLN ARRB1 ATP13A1 CLDN22 CXCL1 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCR1 EMP1 FKBP8 GNA14 GNA15 GNAI2 GNAI3 GPRASP1 GRIA1 MYO5B PPBP PPP2CA RAB11FIP2 RGS12 SLC18A2 SLC39A2 SMCO4 ST13 TMEM147 TMEM80 TRARG1	19 interacting genes: CCL11 CCL21 CCL28 CCL5 CCL8 CXCL11 CXCL12 CXCL14 CXCL5 CXCL6 CXCL9 CXCR1 CXCR2 EPS8 PF4 PIK3R1 PLG XCL1 XCL2
Entrez ID		3579	2920
HPRD ID		00907	00741
Ensembl ID		ENSG00000180871	ENSG00000081041
Uniprot IDs		P25025 Q53PC4	P19875
PDB IDs		4Q3H 5TYT 6KVA 6KVF 6LFM 6LFO 8XVU 8XWA 8XWF 8XWM 8XWN 8XWS 8XWV 8XX3 8XX6 8XX7 8XXH 8XXR 8XXX	1QNK 5OB5 8XVU 8XXH
Enriched GO Terms of Interacting Partners?		Chemokine Activity Neutrophil Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Neutrophil Migration Cell Chemotaxis Granulocyte Chemotaxis CXCR Chemokine Receptor Binding Antimicrobial Humoral Response Granulocyte Migration Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Chemotaxis Cytokine Activity Myeloid Leukocyte Migration Locomotion Leukocyte Chemotaxis G Protein-coupled Receptor Binding Heterotrimeric G-protein Complex Humoral Immune Response G Protein-coupled Receptor Signaling Pathway Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Killing Of Cells Of Another Organism Leukocyte Migration Inflammatory Response Receptor Internalization Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Killing Signal Transduction Import Into Cell Signaling Endocytosis Negative Regulation Of Adenylate Cyclase Activity Cell Communication Cell Migration Calcium-mediated Signaling Cytoplasmic Vesicle Membrane GTPase Activity Receptor-mediated Endocytosis Cellular Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Defense Response To Symbiont Defense Response To Other Organism Cellular Response To Molecule Of Bacterial Origin Cell Motility G Protein-coupled Acetylcholine Receptor Signaling Pathway Cell-cell Signaling Response To Other Organism Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Vesicle-mediated Transport Plasma Membrane	Chemokine Activity Leukocyte Migration Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Leukocyte Chemotaxis Chemotaxis Antimicrobial Humoral Response Cell Migration Locomotion Granulocyte Chemotaxis Chemokine-mediated Signaling Pathway Myeloid Leukocyte Migration Cell Motility Granulocyte Migration Cytokine Activity Humoral Immune Response Cytokine-mediated Signaling Pathway Immune System Process Immune Response Mononuclear Cell Migration Defense Response To Symbiont Defense Response To Other Organism Cell Killing Killing Of Cells Of Another Organism Neutrophil Chemotaxis Inflammatory Response CXCR Chemokine Receptor Binding Defense Response Neutrophil Migration Response To Other Organism Response To External Biotic Stimulus G Protein-coupled Receptor Signaling Pathway CCR Chemokine Receptor Binding Chemokine Receptor Binding Extracellular Space Dendritic Cell Migration Extracellular Region Signal Transduction Cell-cell Signaling Signaling Cell Communication Cell Surface Receptor Signaling Pathway Response To Stress Dendritic Cell Chemotaxis Positive Regulation Of Cell Migration Regulation Of Leukocyte Migration Positive Regulation Of Cell Motility Negative Regulation Of Leukocyte Tethering Or Rolling Positive Regulation Of Locomotion Eosinophil Chemotaxis
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