CXCR2 and ST13

Number of citations of the paper that reports this interaction (PubMedID 11751889)
51

Data Source:
BioGRID (two hybrid, pull down, affinity chromatography technology)
HPRD (in vivo)

		CXCR2	ST13
Description		C-X-C motif chemokine receptor 2	ST13 Hsp70 interacting protein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane External Side Of Plasma Membrane Cell Surface Microtubule Cytoskeleton Membrane Secretory Granule Membrane Mast Cell Granule Mitotic Spindle	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Interleukin-8 Receptor Activity G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity C-C Chemokine Binding Interleukin-8 Binding	Protein Binding Hsp70 Protein Binding Protein-macromolecule Adaptor Activity Protein Dimerization Activity
	Biological Process	Dendritic Cell Chemotaxis Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Population Proliferation Calcium-mediated Signaling Neutrophil Chemotaxis Receptor Internalization Interleukin-8-mediated Signaling Pathway Neutrophil Activation Negative Regulation Of Apoptotic Process Chemokine-mediated Signaling Pathway	Protein Folding Response To Bacterium
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation	Regulation of HSF1-mediated heat shock response
Drugs
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 23128233 28067908) Lymphocyte percentage of white cells ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Neutrophil percentage of white cells ( 27863252 32888494) Smooth-surface caries ( 23470693) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252 32888494)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Feeling nervous ( 29500382) Refractive error ( 32231278)
Interacting Genes		32 interacting genes: ADRA1A ARLN ARRB1 ATP13A1 CLDN22 CXCL1 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCR1 EMP1 FKBP8 GNA14 GNA15 GNAI2 GNAI3 GPRASP1 GRIA1 MYO5B PPBP PPP2CA RAB11FIP2 RGS12 SLC18A2 SLC39A2 SMCO4 ST13 TMEM147 TMEM80 TRARG1	25 interacting genes: ALB APOE ASF1A CD101 CDC42 CTRC CXCR2 F2 GRIK1 HSP90AA1 HSPA1A HSPA1B HSPA4 HSPA8 NOS3 OGT OLFM2 PSEN1 PTGER4 RBFOX2 SMAD2 SNCA SRSF8 TTR VAV2
Entrez ID		3579	6767
HPRD ID		00907	08426
Ensembl ID		ENSG00000180871	ENSG00000100380
Uniprot IDs		P25025 Q53PC4	A0A140VKA6 B4E0U6 P50502 Q0IJ56
PDB IDs		4Q3H 5TYT 6KVA 6KVF 6LFM 6LFO 8XVU 8XWA 8XWF 8XWM 8XWN 8XWS 8XWV 8XX3 8XX6 8XX7 8XXH 8XXR 8XXX
Enriched GO Terms of Interacting Partners?		Chemokine Activity Neutrophil Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Neutrophil Migration Cell Chemotaxis Granulocyte Chemotaxis CXCR Chemokine Receptor Binding Antimicrobial Humoral Response Granulocyte Migration Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Chemotaxis Cytokine Activity Myeloid Leukocyte Migration Locomotion Leukocyte Chemotaxis G Protein-coupled Receptor Binding Heterotrimeric G-protein Complex Humoral Immune Response G Protein-coupled Receptor Signaling Pathway Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Killing Of Cells Of Another Organism Leukocyte Migration Inflammatory Response Receptor Internalization Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Killing Signal Transduction Import Into Cell Signaling Endocytosis Negative Regulation Of Adenylate Cyclase Activity Cell Communication Cell Migration Calcium-mediated Signaling Cytoplasmic Vesicle Membrane GTPase Activity Receptor-mediated Endocytosis Cellular Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Defense Response To Symbiont Defense Response To Other Organism Cellular Response To Molecule Of Bacterial Origin Cell Motility G Protein-coupled Acetylcholine Receptor Signaling Pathway Cell-cell Signaling Response To Other Organism Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Vesicle-mediated Transport Plasma Membrane	ATP-dependent Protein Folding Chaperone Protein-containing Complex Regulation Of Protein-containing Complex Assembly Blood Microparticle C3HC4-type RING Finger Domain Binding Regulation Of Biological Quality Regulation Of Supramolecular Fiber Organization ATP-dependent Protein Disaggregase Activity Protein Refolding Negative Regulation Of Cellular Component Organization Tau Protein Binding Regulation Of Protein Catabolic Process Negative Regulation Of Protein-containing Complex Assembly Protein Folding Chaperone Intracellular Signal Transduction Negative Regulation Of Platelet Activation Inclusion Body Response To Stress Regulation Of Inclusion Body Assembly Positive Regulation Of Supramolecular Fiber Organization Chaperone-mediated Protein Complex Assembly Signal Transduction Disordered Domain Specific Binding Response To Unfolded Protein Response To Heat Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Protein Folding Positive Regulation Of Protein Catabolic Process Calcium Ion Homeostasis Regulation Of Proteolysis Aggresome Negative Regulation Of Protein Metabolic Process Positive Regulation Of Signaling Intracellular Signaling Cassette Positive Regulation Of Amyloid Fibril Formation Unfolded Protein Binding Response To Hormone Ficolin-1-rich Granule Lumen Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Heat Acclimation Receptor Ligand Activity Regulation Of Immune System Process Chaperone-mediated Autophagy Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Cellular Response To Heat Positive Regulation Of Microtubule Nucleation
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