CXCR2 and TMEM80

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		CXCR2	TMEM80
Name		C-X-C motif chemokine receptor 2	transmembrane protein 80
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane External Side Of Plasma Membrane Cell Surface Microtubule Cytoskeleton Membrane Secretory Granule Membrane Mast Cell Granule Mitotic Spindle	Cilium Membrane Ciliary Transition Zone Cell Projection
	Molecular Function	Interleukin-8 Receptor Activity G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity C-C Chemokine Binding Interleukin-8 Binding	Protein Binding
	Biological Process	Dendritic Cell Chemotaxis Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Population Proliferation Calcium-mediated Signaling Neutrophil Chemotaxis Receptor Internalization Interleukin-8-mediated Signaling Pathway Neutrophil Activation Negative Regulation Of Apoptotic Process Chemokine-mediated Signaling Pathway	Non-motile Cilium Assembly
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation	None
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Granulocyte count ( 27863252 ) Granulocyte percentage of myeloid white cells ( 27863252 ) Inflammatory bowel disease ( 23128233 28067908 ) Lymphocyte percentage of white cells ( 27863252 32888494 ) Monocyte percentage of white cells ( 27863252 32888494 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 27863252 32888494 ) Neutrophil percentage of white cells ( 27863252 32888494 ) Smooth-surface caries ( 23470693 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) White blood cell count ( 27863252 32888494 )	No GWAS studies recorded
Interacting Genes		32 interacting genes: ADRA1A ARLN ARRB1 ATP13A1 CLDN22 CXCL1 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCR1 EMP1 FKBP8 GNA14 GNA15 GNAI2 GNAI3 GPRASP1 GRIA1 MYO5B PPBP PPP2CA RAB11FIP2 RGS12 SLC18A2 SLC39A2 SMCO4 ST13 TMEM147 TMEM80 TRARG1	65 interacting genes: ADGRE2 AGTR1 AIG1 AQP1 ARL6IP6 BET1 BIK C11orf24 C14orf180 C3orf52 C5orf46 CCDC167 CD63 CLDN11 CLDN19 CLDN8 CLDND2 CLEC2D CMTM5 CNIH3 COL4A5 CXCR2 CYBC1 DOLK EMD ERMP1 FAM20B FAM3C FKBP8 FXYD3 GPR37L1 IER3IP1 LAT LSMEM1 MALL MRAP2 NKG7 PRB1 PTPN9 PTPRN RPRM SERP2 SLC30A8 SLC66A2 SMAGP SMCO4 STATH STX7 SYNGR1 TLCD1 TMEM100 TMEM107 TMEM109 TMEM120B TMEM128 TMEM14A TMEM243 TMEM65 TNFRSF10C TRARG1 TSPAN1 TSPO2 TVP23B VKORC1L1 WNT4
Entrez ID		3579	283232
HPRD ID		00907	14143
Ensembl ID		ENSG00000180871	ENSG00000177042
Uniprot IDs		P25025 Q53PC4	A0A0A0MTU4 A0AAA9X375 E9PQJ9 Q96HE8
PDB IDs		4Q3H 5TYT 6KVA 6KVF 6LFM 6LFO 8XVU 8XWA 8XWF 8XWM 8XWN 8XWS 8XWV 8XX3 8XX6 8XX7 8XXH 8XXR 8XXX	Not available
GO Terms Enriched among Interactors		Chemokine Activity Neutrophil Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Neutrophil Migration Cell Chemotaxis Granulocyte Chemotaxis CXCR Chemokine Receptor Binding Antimicrobial Humoral Response Granulocyte Migration Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Chemotaxis Cytokine Activity Myeloid Leukocyte Migration Locomotion Leukocyte Chemotaxis G Protein-coupled Receptor Binding Heterotrimeric G-protein Complex Humoral Immune Response G Protein-coupled Receptor Signaling Pathway Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Killing Of Cells Of Another Organism Leukocyte Migration Inflammatory Response Receptor Internalization Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Killing Signal Transduction Import Into Cell Signaling Endocytosis Negative Regulation Of Adenylate Cyclase Activity Cell Communication Cell Migration Calcium-mediated Signaling Cytoplasmic Vesicle Membrane GTPase Activity Receptor-mediated Endocytosis Cellular Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Defense Response To Symbiont Defense Response To Other Organism Cellular Response To Molecule Of Bacterial Origin Cell Motility G Protein-coupled Acetylcholine Receptor Signaling Pathway Cell-cell Signaling Response To Other Organism Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Vesicle-mediated Transport Plasma Membrane	Membrane Plasma Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Protein Binding