CXCL3 and CXCR2

Number of citations of the paper that reports this interaction (PubMedID 8702798)
0

Data Source:
HPRD (in vivo)

		CXCL3	CXCR2
Description		C-X-C motif chemokine ligand 3	C-X-C motif chemokine receptor 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Nucleoplasm Plasma Membrane External Side Of Plasma Membrane Cell Surface Microtubule Cytoskeleton Membrane Secretory Granule Membrane Mast Cell Granule Mitotic Spindle
	Molecular Function	Cytokine Activity Chemokine Activity	Interleukin-8 Receptor Activity G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity C-C Chemokine Binding Interleukin-8 Binding
	Biological Process	Chemotaxis Defense Response Inflammatory Response Immune Response Signal Transduction Neutrophil Chemotaxis Killing Of Cells Of Another Organism Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide	Dendritic Cell Chemotaxis Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Population Proliferation Calcium-mediated Signaling Neutrophil Chemotaxis Receptor Internalization Interleukin-8-mediated Signaling Pathway Neutrophil Activation Negative Regulation Of Apoptotic Process Chemokine-mediated Signaling Pathway
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Urate levels (BMI interaction) ( 25811787)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 23128233 28067908) Lymphocyte percentage of white cells ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Neutrophil percentage of white cells ( 27863252 32888494) Smooth-surface caries ( 23470693) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252 32888494)
Interacting Genes		6 interacting genes: CCL11 CXCL5 CXCL6 CXCR1 CXCR2 XCL2	32 interacting genes: ADRA1A ARLN ARRB1 ATP13A1 CLDN22 CXCL1 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCR1 EMP1 FKBP8 GNA14 GNA15 GNAI2 GNAI3 GPRASP1 GRIA1 MYO5B PPBP PPP2CA RAB11FIP2 RGS12 SLC18A2 SLC39A2 SMCO4 ST13 TMEM147 TMEM80 TRARG1
Entrez ID		2921	3579
HPRD ID		00742	00907
Ensembl ID		ENSG00000163734	ENSG00000180871
Uniprot IDs		P19876	P25025 Q53PC4
PDB IDs		8XWF 8XX3	4Q3H 5TYT 6KVA 6KVF 6LFM 6LFO 8XVU 8XWA 8XWF 8XWM 8XWN 8XWS 8XWV 8XX3 8XX6 8XX7 8XXH 8XXR 8XXX
Enriched GO Terms of Interacting Partners?		Cell Chemotaxis Granulocyte Chemotaxis Chemokine-mediated Signaling Pathway Granulocyte Migration Chemotaxis Locomotion Myeloid Leukocyte Migration Leukocyte Chemotaxis Chemokine Activity Neutrophil Chemotaxis Leukocyte Migration Neutrophil Migration Cell Migration Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cytokine-mediated Signaling Pathway Cell Motility Interleukin-8-mediated Signaling Pathway Immune Response Interleukin-8 Receptor Activity Antimicrobial Humoral Response Inflammatory Response Interleukin-8 Binding Cytokine Activity Humoral Immune Response G Protein-coupled Receptor Signaling Pathway Immune System Process C-X-C Chemokine Receptor Activity CXCR Chemokine Receptor Binding Dendritic Cell Chemotaxis Defense Response Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Dendritic Cell Migration CCR Chemokine Receptor Binding Neutrophil Activation Defense Response To Symbiont Defense Response To Other Organism Cell Surface Receptor Signaling Pathway Signal Transduction Response To Other Organism Receptor Internalization Response To External Biotic Stimulus Secretory Granule Membrane Mononuclear Cell Migration Extracellular Space Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Myeloid Leukocyte Activation Response To Stress Mammary Duct Terminal End Bud Growth	Chemokine Activity Neutrophil Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Neutrophil Migration Cell Chemotaxis Granulocyte Chemotaxis CXCR Chemokine Receptor Binding Antimicrobial Humoral Response Granulocyte Migration Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Chemotaxis Cytokine Activity Myeloid Leukocyte Migration Locomotion Leukocyte Chemotaxis G Protein-coupled Receptor Binding Heterotrimeric G-protein Complex Humoral Immune Response G Protein-coupled Receptor Signaling Pathway Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Killing Of Cells Of Another Organism Leukocyte Migration Inflammatory Response Receptor Internalization Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Killing Signal Transduction Import Into Cell Signaling Endocytosis Negative Regulation Of Adenylate Cyclase Activity Cell Communication Cell Migration Calcium-mediated Signaling Cytoplasmic Vesicle Membrane GTPase Activity Receptor-mediated Endocytosis Cellular Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Defense Response To Symbiont Defense Response To Other Organism Cellular Response To Molecule Of Bacterial Origin Cell Motility G Protein-coupled Acetylcholine Receptor Signaling Pathway Cell-cell Signaling Response To Other Organism Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Vesicle-mediated Transport Plasma Membrane
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?