RPS3 and FOLH1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RPS3	FOLH1
Description		ribosomal protein S3	folate hydrolase 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Endoplasmic Reticulum Spindle Cytosol Ribosome Cytoskeleton Plasma Membrane Focal Adhesion Postsynaptic Density Small Ribosomal Subunit Membrane Cytosolic Ribosome Cytosolic Small Ribosomal Subunit Ruffle Membrane Synapse Extracellular Exosome NF-kappaB Complex Mitotic Spindle Ribonucleoprotein Complex	Cytoplasm Plasma Membrane Cell Surface Membrane Extracellular Exosome
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Damaged DNA Binding RNA Binding MRNA Binding Structural Constituent Of Ribosome DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity DNA Endonuclease Activity Protein Binding Microtubule Binding Tubulin Binding Lyase Activity DNA N-glycosylase Activity Enzyme Binding Kinase Binding Protein Kinase Binding Hsp70 Protein Binding Oxidized Purine DNA Binding Oxidized Pyrimidine DNA Binding Ubiquitin-like Protein Conjugating Enzyme Binding Protein-containing Complex Binding Protein Kinase A Binding Iron-sulfur Cluster Binding Hsp90 Protein Binding Small Ribosomal Subunit RRNA Binding Supercoiled DNA Binding Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity DNA-binding Transcription Factor Binding	Catalytic Activity Carboxypeptidase Activity Metallocarboxypeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Dipeptidase Activity Metal Ion Binding Ac-Asp-Glu Binding Tetrahydrofolyl-poly(glutamate) Polymer Binding
	Biological Process	Cytoplasmic Translation DNA Repair Base-excision Repair Translation Translational Initiation Regulation Of Translation Apoptotic Process DNA Damage Response Chromosome Segregation Positive Regulation Of Gene Expression Negative Regulation Of Translation Positive Regulation Of Microtubule Polymerization Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Protein Ubiquitination Positive Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of Interleukin-2 Production Cellular Response To Reactive Oxygen Species Positive Regulation Of Activated T Cell Proliferation Regulation Of Apoptotic Process Negative Regulation Of DNA Repair Positive Regulation Of DNA Repair Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Spindle Assembly Cell Division Response To TNF Agonist Cellular Response To Hydrogen Peroxide Cellular Response To Tumor Necrosis Factor Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Base-excision Repair Positive Regulation Of Apoptotic Signaling Pathway	Proteolysis Glutamate Biosynthetic Process Folic Acid-containing Compound Metabolic Process Intestinal Folate Absorption Positive Regulation Of Glutamate Receptor Signaling Pathway
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency SARS-CoV-1 modulates host translation machinery SARS-CoV-2 modulates host translation machinery Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	Aspartate and asparagine metabolism
Drugs			Capromab pendetide Glutamic acid (2S)-2-{[HYDROXY(4-IODOBENZYL)PHOSPHORYL]METHYL}PENTANEDIOIC ACID DCFBC Spaglumic acid Piflufolastat F 18
Diseases
GWAS			Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) Body size at age 10 ( 32376654) Fasting glucose ( 34059833) Feeling fed-up ( 29500382) HDL cholesterol ( 19060911) HDL cholesterol levels ( 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Height ( 20881960) Intraocular pressure ( 29617998) Serum metabolite concentrations in chronic kidney disease ( 33838163) Serum metabolite levels ( 33031748) Systolic blood pressure ( 30578418) Systolic blood pressure x dichotomous lifestyle risk score interaction (2df test) ( 32227373) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		28 interacting genes: ATP6V0D2 CCT2 CDK1 CDK2 CSNK2A1 DDIT3 DUX4 FNDC3B FOLH1 FOXP1 HSP90AA1 IL7R MDM2 NDRG1 NFKB1 OGT PTEN RELA RNF10 RPL9 SUMO1 SUMO2 UBC UBXN7 USP7 WBP2 YWHAQ ZNF598	4 interacting genes: C3orf52 LCOR MTAP RPS3
Entrez ID		6188	2346
HPRD ID		10941	02961
Ensembl ID		ENSG00000149273	ENSG00000086205
Uniprot IDs		P23396	Q04609
PDB IDs		1WH9 4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6FEC 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBS 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOL 6ZON 6ZP4 6ZUO 6ZV6 6ZVH 6ZVJ 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7A09 7K5I 7QP6 7QP7 7QVP 7R4X 7TQL 7XNX 7XNY 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IFD 8IFE 8JDJ 8JDK 8JDL 8JDM 8K2C 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPK 8PPL 8QOI 8T4S 8UKB 8XP2 8XP3 8XSX 8XSY 8XSZ 8XXL 8XXM 8XXN 8Y0W 8Y0X 8YOO 8YOP 8ZDB 8ZDC 8ZDD 9BKD 9BLN 9C3H 9G8M 9G8O	1Z8L 2C6C 2C6G 2C6P 2CIJ 2JBJ 2JBK 2OOT 2OR4 2PVV 2PVW 2XEF 2XEG 2XEI 2XEJ 3BHX 3BI0 3BI1 3BXM 3D7D 3D7F 3D7G 3D7H 3IWW 3RBU 3SJE 3SJF 3SJG 3SJX 4JYW 4JZ0 4LQG 4MCP 4MCQ 4MCR 4MCS 4NGM 4NGN 4NGP 4NGQ 4NGR 4NGS 4NGT 4OC0 4OC1 4OC2 4OC3 4OC4 4OC5 4OME 4P44 4P45 4P4B 4P4D 4P4E 4P4F 4P4I 4P4J 4W9Y 4X3R 5D29 5ELY 5F09 5O5R 5O5T 5O5U 5OF0 6ETY 6EZ9 6F5L 6FE5 6H7Y 6H7Z 6HKJ 6HKZ 6RBC 6RTI 6S1X 6SGP 6SKH 7BFZ 8BO8 8BOL 8BOW
Enriched GO Terms of Interacting Partners?		Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Regulation Of Proteasomal Protein Catabolic Process Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Cytosol Regulation Of Proteolysis Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Intracellular Signal Transduction Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Regulation Of RNA Metabolic Process PML Body Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Protein Tag Activity Regulation Of Protein Stability Protein Stabilization NF-kappaB P50/p65 Complex DNA Damage Response Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Negative Regulation Of Biosynthetic Process Signal Transduction In Response To DNA Damage Macromolecule Metabolic Process Protein Catabolic Process Post-translational Protein Modification Nucleoplasm Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cyclin-dependent Protein Kinase Activity Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Gene Expression Apoptotic Process Negative Regulation Of Metabolic Process Regulation Of DNA Metabolic Process Programmed Cell Death Regulation Of Schwann Cell Differentiation Cell Death Positive Regulation Of Gene Expression Regulation Of Protein Metabolic Process	Nicotinamide Riboside Catabolic Process S-methyl-5-thioadenosine Phosphorylase Activity Positive Regulation Of Base-excision Repair Response To TNF Agonist Oxidized Pyrimidine DNA Binding Purine Ribonucleoside Salvage L-methionine Salvage From Methylthioadenosine L-methionine Salvage Pentosyltransferase Activity 1,4-alpha-oligoglucan Phosphorylase Activity Oxidized Purine DNA Binding Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of Deoxyribonuclease Activity Ubiquitin-like Protein Conjugating Enzyme Binding Supercoiled DNA Binding Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Positive Regulation Of Endodeoxyribonuclease Activity Small Ribosomal Subunit RRNA Binding NF-kappaB Complex Regulation Of Base-excision Repair DNA N-glycosylase Activity Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Methionine Biosynthetic Process Nucleoside Salvage DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Nucleobase-containing Small Molecule Catabolic Process Methionine Metabolic Process Histone Methyltransferase Binding Sulfur Amino Acid Biosynthetic Process Positive Regulation Of T Cell Receptor Signaling Pathway Ubiquitin-specific Protease Binding DNA Endonuclease Activity Protein Kinase A Binding Purine Nucleoside Metabolic Process Small Ribosomal Subunit Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Purine-containing Compound Salvage Positive Regulation Of Microtubule Polymerization Sulfur Amino Acid Metabolic Process Base-excision Repair Cellular Response To Estradiol Stimulus Response To Testosterone Cytosolic Small Ribosomal Subunit Positive Regulation Of Interleukin-2 Production Hsp90 Protein Binding Nuclear Estrogen Receptor Binding Aspartate Family Amino Acid Metabolic Process Regulation Of Activated T Cell Proliferation Negative Regulation Of DNA Repair
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