RRAGA and NOL8

Number of citations of the paper that reports this interaction (PubMedID 14660641)
0

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		RRAGA	NOL8
Description		Ras related GTP binding A	nucleolar protein 8
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane GATOR1 Complex Gtr1-Gtr2 GTPase Complex FNIP-folliculin RagC/D GAP	Nucleus Chromosome Nucleolus
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Protein-membrane Adaptor Activity Protein Heterodimerization Activity Phosphoprotein Binding	Nucleic Acid Binding RNA Binding Protein Binding
	Biological Process	Autophagosome Assembly Cytoplasmic Translation Apoptotic Process Intracellular Protein Localization Cellular Response To Starvation Negative Regulation Of Autophagy Cellular Response To Nutrient Levels Positive Regulation Of TOR Signaling Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Amino Acid Starvation Intracellular Signal Transduction TORC1 Signaling Glucose Homeostasis Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Cellular Response To Methionine Protein Localization To Lysosome Cellular Response To Amino Acid Stimulus Protein Localization To Membrane Positive Regulation Of TORC1 Signaling	RRNA Processing Protein Localization To Nucleolus
Pathways		Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes E3 ubiquitin ligases ubiquitinate target proteins Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs
Diseases
GWAS			Malaria ( 31844061)
Interacting Genes		5 interacting genes: DYNLT1 FLCN IL7R NOL8 RRAGC	7 interacting genes: NIP7 RBFOX2 RNF10 RRAGA RRAGC RRAGD SNRNP40
Entrez ID		10670	55035
HPRD ID		10205	11397
Ensembl ID		ENSG00000155876	ENSG00000198000
Uniprot IDs		Q7L523	A6H8Z4 Q76FK4
PDB IDs		5X6V 6CES 6EHR 6NZD 6S6A 6S6D 6SB0 6SB2 6U62 6ULG 6WJ2 6WJ3 7T3A 7T3B 7T3C 7UX2 7UXC 7UXH 8DHB
Enriched GO Terms of Interacting Partners?		FNIP-folliculin RagC/D GAP Lysosome Organization Negative Regulation Of Protein Localization To Nucleus Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Positive Regulation Of TORC1 Signaling Protein Destabilization SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process TORC1 Signaling Transport Of Viral Material Towards Nucleus Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Positive Regulation Of TOR Signaling TOR Signaling Regulation Of TORC1 Signaling Interleukin-7 Receptor Activity Intracellular Transport Of Viral Protein In Host Cell Regulation Of TOR Signaling Regulation Of Protein Localization To Nucleus Hemopoiesis Vacuole Organization Cellular Response To Starvation Gtr1-Gtr2 GTPase Complex Negative Regulation Of Lysosome Organization Negative Regulation Of Cell Proliferation Involved In Kidney Development Negative Regulation Of Brown Fat Cell Differentiation Negative Regulation Of Protein Localization Response To Starvation Spindle Interleukin-7-mediated Signaling Pathway Positive Regulation Of T Cell Differentiation In Thymus Intracellular Transport Of Virus Cellular Response To Nutrient Levels Regulation Of Pro-B Cell Differentiation Host Cell Secretory Vesicle Negative Regulation Of T Cell Mediated Cytotoxicity Cell Proliferation Involved In Kidney Development Protein Localization To Nucleolus Regulation Of Lymphoid Progenitor Cell Differentiation Regulation Of Signal Transduction Lysosomal Membrane Regulation Of Protein Stability Regulation Of Autophagy Regulation Of Lysosome Organization Negative Regulation Of Catabolic Process Enzyme-substrate Adaptor Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Gtr1-Gtr2 GTPase Complex Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Positive Regulation Of TORC1 Signaling FNIP-folliculin RagC/D GAP Positive Regulation Of TOR Signaling Cellular Response To Amino Acid Stimulus Regulation Of TORC1 Signaling Negative Regulation Of Autophagy Response To Amino Acid Regulation Of TOR Signaling Cellular Response To Starvation Response To Starvation Protein-membrane Adaptor Activity Cellular Response To Nutrient Levels GTPase Binding Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation GTPase Activity Protein Localization To Lysosome Protein Heterodimerization Activity RNA Splicing GTP Binding TORC1 Signaling Lysosomal Membrane Regulation Of Autophagy Negative Regulation Of Catabolic Process GDP Binding TOR Signaling Protein Localization To Vacuole Autophagosome Assembly Response To Nutrient Levels Lysosome Autophagosome Organization Regulation Of Translational Initiation Nucleoplasm Nucleus Cytoplasmic Translation Positive Regulation Of Translation Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane GATOR1 Complex Vacuole Organization Organelle Assembly Negative Regulation Of Translation Cellular Response To Methionine Molecular Adaptor Activity Response To Methionine Sno(s)RNA-containing Ribonucleoprotein Complex Negative Regulation Of Schwann Cell Proliferation
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