RRAGA and DYNLT1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RRAGA	DYNLT1
Description		Ras related GTP binding A	dynein light chain Tctex-type 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane GATOR1 Complex Gtr1-Gtr2 GTPase Complex FNIP-folliculin RagC/D GAP	Extracellular Region Cytoplasm Golgi Apparatus Spindle Cytoskeleton Cytoplasmic Dynein Complex Microtubule Cytoplasmic Microtubule Dynein Complex Secretory Granule Lumen Host Cell Secretory Vesicle Ficolin-1-rich Granule Lumen
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Protein-membrane Adaptor Activity Protein Heterodimerization Activity Phosphoprotein Binding	Protein Binding Identical Protein Binding Dynein Intermediate Chain Binding
	Biological Process	Autophagosome Assembly Cytoplasmic Translation Apoptotic Process Intracellular Protein Localization Cellular Response To Starvation Negative Regulation Of Autophagy Cellular Response To Nutrient Levels Positive Regulation Of TOR Signaling Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Amino Acid Starvation Intracellular Signal Transduction TORC1 Signaling Glucose Homeostasis Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Cellular Response To Methionine Protein Localization To Lysosome Cellular Response To Amino Acid Stimulus Protein Localization To Membrane Positive Regulation Of TORC1 Signaling	Establishment Of Mitotic Spindle Orientation Microtubule-based Movement Nervous System Development Regulation Of G Protein-coupled Receptor Signaling Pathway Intracellular Transport Of Viral Protein In Host Cell Positive Regulation Of Intracellular Transport Symbiont Entry Into Host Cell Negative Regulation Of Neurogenesis Cell Division Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Transport Of Viral Material Towards Nucleus
Pathways		Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes E3 ubiquitin ligases ubiquitinate target proteins Regulation of PTEN gene transcription Amino acids regulate mTORC1	Neutrophil degranulation
Drugs
Diseases
GWAS
Interacting Genes		5 interacting genes: DYNLT1 FLCN IL7R NOL8 RRAGC	48 interacting genes: ACOX2 ACTN1 APP ARID4B BAG3 BMPR2 CCDC68 DDX54 DHX33 DNAJA2 DOC2A DOC2B DVL1 DVL2 DYNC1I1 DYNC1I2 FXR2 HAVCR1 HSPB7 HSPB9 ILF2 KIF2A KLK15 LNX1 NHSL2 NTAQ1 NUP153 NUP62 OLFM3 PELO PITX2 PSMA1 PTGES3L-AARSD1 PTH2R PVR RAD21 RBM14 RRAGA SDCBP SIRPA SVIL TCEANC TROAP TUBA3C TXN UXT VDAC1 XRN2
Entrez ID		10670	6993
HPRD ID		10205	15987
Ensembl ID		ENSG00000155876	ENSG00000146425
Uniprot IDs		Q7L523	P63172
PDB IDs		5X6V 6CES 6EHR 6NZD 6S6A 6S6D 6SB0 6SB2 6U62 6ULG 6WJ2 6WJ3 7T3A 7T3B 7T3C 7UX2 7UXC 7UXH 8DHB	5JPW 8J07 8PR0 8PR1 8PTK 8RGI
Enriched GO Terms of Interacting Partners?		FNIP-folliculin RagC/D GAP Lysosome Organization Negative Regulation Of Protein Localization To Nucleus Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Positive Regulation Of TORC1 Signaling Protein Destabilization SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process TORC1 Signaling Transport Of Viral Material Towards Nucleus Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Positive Regulation Of TOR Signaling TOR Signaling Regulation Of TORC1 Signaling Interleukin-7 Receptor Activity Intracellular Transport Of Viral Protein In Host Cell Regulation Of TOR Signaling Regulation Of Protein Localization To Nucleus Hemopoiesis Vacuole Organization Cellular Response To Starvation Gtr1-Gtr2 GTPase Complex Negative Regulation Of Lysosome Organization Negative Regulation Of Cell Proliferation Involved In Kidney Development Negative Regulation Of Brown Fat Cell Differentiation Negative Regulation Of Protein Localization Response To Starvation Spindle Interleukin-7-mediated Signaling Pathway Positive Regulation Of T Cell Differentiation In Thymus Intracellular Transport Of Virus Cellular Response To Nutrient Levels Regulation Of Pro-B Cell Differentiation Host Cell Secretory Vesicle Negative Regulation Of T Cell Mediated Cytotoxicity Cell Proliferation Involved In Kidney Development Protein Localization To Nucleolus Regulation Of Lymphoid Progenitor Cell Differentiation Regulation Of Signal Transduction Lysosomal Membrane Regulation Of Protein Stability Regulation Of Autophagy Regulation Of Lysosome Organization Negative Regulation Of Catabolic Process Enzyme-substrate Adaptor Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Aggresome Chemical Synaptic Transmission Frizzled Binding Trans-synaptic Signaling Synaptic Signaling Synapse PTB Domain Binding Convergent Extension Involved In Neural Plate Elongation Microtubule-based Process Outflow Tract Morphogenesis Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cytoplasm Presynapse Regulation Of JNK Cascade Amyloid Fibril Formation Convergent Extension Involved In Organogenesis Regulation Of Spontaneous Synaptic Transmission Spindle Pole Convergent Extension Involved In Gastrulation Aggresome Assembly Spontaneous Neurotransmitter Secretion Synaptic Vesicle Exocytosis Positive Regulation Of Cellular Component Organization Transport Along Microtubule Vesicle-mediated Transport In Synapse Dynein Light Chain Binding Neurotransmitter Transport Positive Regulation Of Neuron Projection Arborization Neurotransmitter Secretion Protein-folding Chaperone Binding Cellular Response To Manganese Ion Regulated Exocytosis Regulation Of Exocytosis Centriolar Subdistal Appendage Inclusion Body Assembly Cytoskeleton-dependent Intracellular Transport Negative Regulation Of Transport Apoptotic Process Hsp70 Protein Binding Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Type 2 Mitophagy Cell-cell Signaling Microtubule-based Transport Programmed Cell Death Cell Death Microtubule Convergent Extension Calcium-dependent Activation Of Synaptic Vesicle Fusion Microtubule Motor Activity Response To Manganese Ion
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