IL3RA and SAE1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		IL3RA	SAE1
Description		interleukin 3 receptor subunit alpha	SUMO1 activating enzyme subunit 1
Image
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex	Nucleus Nucleoplasm Cytoplasm SUMO Activating Enzyme Complex
	Molecular Function	Cytokine Receptor Activity Interleukin-3 Receptor Activity Protein Binding Cytokine Binding	Ubiquitin Activating Enzyme Activity Protein Binding Enzyme Activator Activity Ubiquitin-like Modifier Activating Enzyme Activity Ligase Activity SUMO Activating Enzyme Activity ATP-dependent Protein Binding Small Protein Activating Enzyme Binding Protein Heterodimerization Activity
	Biological Process	Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Cellular Response To Interleukin-3 Interleukin-3-mediated Signaling Pathway	Protein Ubiquitination Protein Sumoylation Positive Regulation Of Protein Sumoylation Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin receptor SHC signaling	SUMO is conjugated to E1 (UBA2:SAE1) SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is transferred from E1 to E2 (UBE2I, UBC9)
Drugs		Sargramostim Tagraxofusp
Diseases
GWAS		Schizophrenia ( 17522711)	Hematocrit ( 32888494) Hemoglobin ( 32888494) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Multiple sclerosis ( 21833088 31604244) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376) Neutrophil percentage of white cells ( 32888494) Red blood cell count ( 32888494) White blood cell count ( 27863252 32888494)
Interacting Genes		32 interacting genes: BMP10 C2CD2L CDC25A CDK1 CISH CLDN19 CSF2 CSF2RB EMP3 FOXP1 GIMAP1 GNA12 IL3 JAGN1 JAK1 JAK2 LNX1 NINJ2 NR0B2 PAQR5 PPP1CC SAE1 SERP1 SGK2 SMAGP SYS1 TMEM128 TMEM147 TMEM254 TMEM65 TRARG1 VAMP5	22 interacting genes: AGTR1 APP CEBPA CRX ERCC6 ETV4 HSPA1A HSPA2 IL3RA MEOX2 NFYC PAX5 PAX6 PAX8 PTK2 SUMO2 SUMO3 UBA2 UBD UBE2E3 UBE2I USP39
Entrez ID		3563	10055
HPRD ID		02392	18010
Ensembl ID		ENSG00000185291	ENSG00000142230
Uniprot IDs		P26951	Q9UBE0
PDB IDs		4JZJ 5UV8 5UWC 6NMY	1Y8Q 1Y8R 3KYC 3KYD 6CWY 6CWZ 6XOG 6XOH 6XOI 8VY5
Enriched GO Terms of Interacting Partners?		Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Granulocyte Macrophage Colony-stimulating Factor Receptor Complex Interleukin-3-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Cell Surface Receptor Signaling Pathway Via JAK-STAT Cytokine-mediated Signaling Pathway Regulation Of Insulin Secretion Positive Regulation Of Insulin Secretion Positive Regulation Of Establishment Of Protein Localization Regulation Of Organ Growth Regulation Of Peptide Hormone Secretion Regulation Of Establishment Of Protein Localization Interleukin-5-mediated Signaling Pathway Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Cellular Response To Interleukin-3 Positive Regulation Of Protein Transport Neutrophil Differentiation Positive Regulation Of Organ Growth Regulation Of Cell Population Proliferation Regulation Of Protein Transport Ventricular Cardiac Muscle Cell Development Positive Regulation Of Protein Localization Growth Hormone Receptor Binding Regulation Of Hormone Secretion Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion Regulation Of Protein Secretion Establishment Of Protein Localization To Plasma Membrane Mitotic Nuclear Membrane Disassembly Regulation Of Protein Localization Positive Regulation Of Cell Population Proliferation Regulation Of Heart Growth Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Nuclear Membrane Disassembly Type II Interferon-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Membrane Disassembly Interleukin-6-mediated Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Establishment Of Protein Localization To Membrane Regulation Of Growth Positive Regulation Of Protein Localization To Nucleus Nuclear Envelope Organization Growth Hormone Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Circadian Rhythm Positive Regulation Of Cardiac Muscle Cell Proliferation Myeloid Cell Differentiation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle	Positive Regulation Of Transcription By RNA Polymerase II Nucleus Protein Sumoylation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Positive Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Proteolysis Post-translational Protein Modification Positive Regulation Of Cell Differentiation Nucleoplasm Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Modification By Small Protein Conjugation Small Protein Activating Enzyme Binding Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Biosynthetic Process Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Protein Heterodimerization Activity Regulation Of RNA Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Epithelial Cell Differentiation Regulation Of Macromolecule Metabolic Process Regulation Of Proteolysis HMG Box Domain Binding Protein Modification Process Negative Regulation Of Inclusion Body Assembly Macromolecule Metabolic Process DNA Binding Positive Regulation Of Protein Catabolic Process Positive Regulation Of Developmental Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Tag Activity DNA-templated Transcription Sequence-specific DNA Binding Chromatin Binding SUMO Transferase Activity
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