IL3RA and CSF2RB

Number of citations of the paper that reports this interaction (PubMedID 8649415)
56

Data Source:
HPRD (in vitro)

		IL3RA	CSF2RB
Description		interleukin 3 receptor subunit alpha	colony stimulating factor 2 receptor subunit beta
Image
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex	Plasma Membrane External Side Of Plasma Membrane Membrane Granulocyte Macrophage Colony-stimulating Factor Receptor Complex
	Molecular Function	Cytokine Receptor Activity Interleukin-3 Receptor Activity Protein Binding Cytokine Binding	Cytokine Receptor Activity Interleukin-3 Receptor Activity Interleukin-5 Receptor Activity Protein Binding Coreceptor Activity Signaling Receptor Activity
	Biological Process	Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Cellular Response To Interleukin-3 Interleukin-3-mediated Signaling Pathway	Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Respiratory Gaseous Exchange By Respiratory System Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Cellular Response To Interleukin-3 Interleukin-5-mediated Signaling Pathway Interleukin-3-mediated Signaling Pathway Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Leukocyte Proliferation
Pathways		Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin receptor SHC signaling	Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Surfactant metabolism Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4 Interleukin receptor SHC signaling
Drugs		Sargramostim Tagraxofusp	Sargramostim NPI 32101 Resatorvid
Diseases
GWAS		Schizophrenia ( 17522711)	Blood protein levels ( 30072576) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Femur bone mineral density x serum urate levels interaction ( 34046847) Inflammatory bowel disease ( 27569725) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mosquito bite size ( 28199695) Multiple sclerosis ( 24076602 31604244) Multiple sclerosis and LDL levels (pleiotropy) ( 26920376) Perceived unattractiveness to mosquitoes ( 28199695)
Interacting Genes		32 interacting genes: BMP10 C2CD2L CDC25A CDK1 CISH CLDN19 CSF2 CSF2RB EMP3 FOXP1 GIMAP1 GNA12 IL3 JAGN1 JAK1 JAK2 LNX1 NINJ2 NR0B2 PAQR5 PPP1CC SAE1 SERP1 SGK2 SMAGP SYS1 TMEM128 TMEM147 TMEM254 TMEM65 TRARG1 VAMP5	27 interacting genes: CISH CSF2 CSF2RA EPOR FES FYN HCK IKBKB IL3 IL3RA IL5RA JAK1 JAK2 KDR KIT LCK LYN MAD2L1 PRKCB PTPN11 PTPN6 RACK1 SHC1 STAT1 STAT3 SYK YWHAZ
Entrez ID		3563	1439
HPRD ID		02392	00739
Ensembl ID		ENSG00000185291	ENSG00000100368
Uniprot IDs		P26951	P32927 Q6NSJ8
PDB IDs		4JZJ 5UV8 5UWC 6NMY	1C8P 1EGJ 1GH7 2GYS 2NA8 2NA9 4NKQ 5DWU 8TLD
Enriched GO Terms of Interacting Partners?		Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Granulocyte Macrophage Colony-stimulating Factor Receptor Complex Interleukin-3-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Cell Surface Receptor Signaling Pathway Via JAK-STAT Cytokine-mediated Signaling Pathway Regulation Of Insulin Secretion Positive Regulation Of Insulin Secretion Positive Regulation Of Establishment Of Protein Localization Regulation Of Organ Growth Regulation Of Peptide Hormone Secretion Regulation Of Establishment Of Protein Localization Interleukin-5-mediated Signaling Pathway Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Cellular Response To Interleukin-3 Positive Regulation Of Protein Transport Neutrophil Differentiation Positive Regulation Of Organ Growth Regulation Of Cell Population Proliferation Regulation Of Protein Transport Ventricular Cardiac Muscle Cell Development Positive Regulation Of Protein Localization Growth Hormone Receptor Binding Regulation Of Hormone Secretion Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion Regulation Of Protein Secretion Establishment Of Protein Localization To Plasma Membrane Mitotic Nuclear Membrane Disassembly Regulation Of Protein Localization Positive Regulation Of Cell Population Proliferation Regulation Of Heart Growth Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Nuclear Membrane Disassembly Type II Interferon-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Membrane Disassembly Interleukin-6-mediated Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Establishment Of Protein Localization To Membrane Regulation Of Growth Positive Regulation Of Protein Localization To Nucleus Nuclear Envelope Organization Growth Hormone Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Circadian Rhythm Positive Regulation Of Cardiac Muscle Cell Proliferation Myeloid Cell Differentiation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle	Cytokine-mediated Signaling Pathway Phosphorylation Cell Surface Receptor Signaling Pathway Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Signal Transduction Positive Regulation Of Cell Population Proliferation Fc Receptor Signaling Pathway Regulation Of Developmental Process Enzyme-linked Receptor Protein Signaling Pathway Protein Kinase Activity Positive Regulation Of Signal Transduction Protein Modification Process Phosphate-containing Compound Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Population Proliferation Regulation Of Multicellular Organismal Development Cell Surface Receptor Signaling Pathway Via STAT SH2 Domain Binding Kinase Activity Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Phosphotyrosine Residue Binding Interleukin-3-mediated Signaling Pathway Regulation Of Signal Transduction Hemopoiesis Regulation Of Leukocyte Proliferation Positive Regulation Of Multicellular Organismal Process Growth Hormone Receptor Signaling Pathway Cytoplasmic Side Of Plasma Membrane Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Protein Autophosphorylation Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Multicellular Organismal Process Immune System Process Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Positive Regulation Of Developmental Process Regulation Of Anatomical Structure Morphogenesis Regulation Of Signaling Regulation Of Cell Communication Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Leukocyte Proliferation Immune Response
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