IL3RA and FOXP1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		IL3RA	FOXP1
Gene Name		interleukin 3 receptor, alpha (low affinity)	forkhead box P1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Nucleus Nucleoplasm
	Molecular Function	Interleukin-3 Receptor Activity	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Metal Ion Binding Androgen Receptor Binding
	Biological Process	Cellular Response To Interleukin-3 Interleukin-3-mediated Signaling Pathway	Negative Regulation Of B Cell Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Positive Regulation Of Endothelial Cell Migration Osteoclast Differentiation Response To Lipopolysaccharide Regulation Of Tumor Necrosis Factor Production Chemokine (C-C Motif) Ligand 2 Secretion Osteoclast Development Macrophage Activation Monocyte Activation Endothelial Cell Activation Regulation Of Monocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Interleukin-1 Beta Secretion Regulation Of Inflammatory Response Negative Regulation Of Androgen Receptor Signaling Pathway T Follicular Helper Cell Differentiation Interleukin-21 Secretion Regulation Of Defense Response To Bacterium Regulation Of Macrophage Colony-stimulating Factor Production Regulation Of Endothelial Tube Morphogenesis Regulation Of Interleukin-12 Secretion
Pathways		Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system GPCR downstream signaling Signaling by Interleukins Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling
Drugs		Sargramostim
Diseases
GWAS		Schizophrenia ( 17522711)	Attention deficit hyperactivity disorder ( 18821565) Subcutaneous adipose tissue ( 22589738)
Protein-Protein Interactions		15 interactors: CDC25A CDK1 CISH CSF2 CSF2RB FOXP1 GNA12 IL3 JAK1 JAK2 LNX1 NR0B2 PPP1CC SAE1 SGK2	5 interactors: CTBP1 FOXP2 FOXP4 IL3RA NCOR2
Entrez ID		3563	27086
HPRD ID		02392	18518
Ensembl ID		ENSG00000185291	ENSG00000114861
Uniprot IDs		P26951	E9PFD3 Q548T7 Q8N2P0 Q8TEA2 Q9H334
PDB IDs			2KIU
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Regulation Of JAK-STAT Cascade Response To Organic Substance Cellular Response To Organic Substance Regulation Of Signaling Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Cytokine-mediated Signaling Pathway Positive Regulation Of JAK-STAT Cascade Positive Regulation Of DNA Replication Regulation Of Signal Transduction Regulation Of Cell Proliferation Cellular Response To Cytokine Stimulus Positive Regulation Of Protein Import Into Nucleus, Translocation Regulation Of Protein Phosphorylation Cellular Protein Modification Process Response To Lipopolysaccharide Cellular Response To Stimulus Response To Molecule Of Bacterial Origin Response To Stimulus Response To Cytokine Regulation Of Protein Import Into Nucleus, Translocation Regulation Of DNA Replication Immune Response Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Positive Regulation Of DNA Metabolic Process Positive Regulation Of Cell Proliferation Growth Hormone Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Response To Lipid Cellular Response To Growth Hormone Stimulus Enzyme Linked Receptor Protein Signaling Pathway Macrophage Activation Regulation Of Phosphorus Metabolic Process Response To Toxic Substance Regulation Of Protein Metabolic Process Response To Bacterium Cell Surface Receptor Signaling Pathway Signal Transduction Peptidyl-tyrosine Autophosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Response To Growth Hormone Histone Phosphorylation Regulation Of Cardiac Muscle Cell Proliferation Cellular Protein Metabolic Process Cellular Response To Hormone Stimulus Regulation Of Intracellular Signal Transduction	White Fat Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Lung Development Respiratory Tube Development Respiratory System Development Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Lung Epithelial Cell Differentiation Lung Cell Differentiation Lung Epithelium Development Regulation Of Transcription From RNA Polymerase II Promoter Putamen Development Caudate Nucleus Development Regulation Of Cellular Ketone Metabolic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter By Histone Modification Tube Development Fat Cell Differentiation Negative Regulation Of Cellular Metabolic Process Interleukin-3-mediated Signaling Pathway Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Lung Goblet Cell Differentiation Vocal Learning Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Cellular Response To Interleukin-3 Righting Reflex Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Telencephalon Development RNA Metabolic Process Negative Regulation Of Histone H4 Acetylation Gene Expression Auditory Behavior Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Lung Secretory Cell Differentiation Striatum Development Forebrain Development Tissue Development Regulation Of Histone H4 Acetylation Mechanosensory Behavior Type I Pneumocyte Differentiation Response To Auditory Stimulus Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Histone Deacetylation Negative Regulation Of Histone Acetylation Heart Development
Tagcloud ?		bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il10ra il10rb il11ra il6st lifr lymphatic microarrays myl9 mylk myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify	3p amplifications breeding classic consuming cooperates costly daunting drive drivers driving endogenously engineering faithful hidden incurable pc pten ptenloxp rapidcap recreate reside rybp sensitized shq1 trp53 trp53loxp unmet validation
Tagcloud (Difference) ?		bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il10ra il10rb il11ra il6st lifr lymphatic microarrays myl9 mylk myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify	3p amplifications breeding classic consuming cooperates costly daunting drive drivers driving endogenously engineering faithful hidden incurable pc pten ptenloxp rapidcap recreate reside rybp sensitized shq1 trp53 trp53loxp unmet validation
Tagcloud (Intersection) ?