IL3RA and CISH

Number of citations of the paper that reports this interaction (PubMedID 7796808)
50

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		IL3RA	CISH
Description		interleukin 3 receptor subunit alpha	cytokine inducible SH2 containing protein
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex	Cytosol Plasma Membrane
	Molecular Function	Cytokine Receptor Activity Interleukin-3 Receptor Activity Protein Binding Cytokine Binding	Cytokine Receptor Binding Protein Binding
	Biological Process	Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Cellular Response To Interleukin-3 Interleukin-3-mediated Signaling Pathway	Regulation Of Cell Growth Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Signal Transduction Protein Ubiquitination Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Pathways		Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin receptor SHC signaling	Interleukin-7 signaling Neddylation Growth hormone receptor signaling
Drugs		Sargramostim Tagraxofusp
Diseases
GWAS		Schizophrenia ( 17522711)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Cortical surface area (MOSTest) ( 32665545) Eosinophil percentage of white cells ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		32 interacting genes: BMP10 C2CD2L CDC25A CDK1 CISH CLDN19 CSF2 CSF2RB EMP3 FOXP1 GIMAP1 GNA12 IL3 JAGN1 JAK1 JAK2 LNX1 NINJ2 NR0B2 PAQR5 PPP1CC SAE1 SERP1 SGK2 SMAGP SYS1 TMEM128 TMEM147 TMEM254 TMEM65 TRARG1 VAMP5	20 interacting genes: CSF2RB CSF3R EPOR ERBB2 ETV5 GHR HSPA6 IL2RB IL3RA JAK1 JAK2 JAK3 KIT MAP3K7CL MYD88 PRKCA PRKCB PRKCQ PRLR SMAD2
Entrez ID		3563	1154
HPRD ID		02392	03897
Ensembl ID		ENSG00000185291	ENSG00000114737
Uniprot IDs		P26951	Q9NSE2
PDB IDs		4JZJ 5UV8 5UWC 6NMY
Enriched GO Terms of Interacting Partners?		Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Granulocyte Macrophage Colony-stimulating Factor Receptor Complex Interleukin-3-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Cell Surface Receptor Signaling Pathway Via JAK-STAT Cytokine-mediated Signaling Pathway Regulation Of Insulin Secretion Positive Regulation Of Insulin Secretion Positive Regulation Of Establishment Of Protein Localization Regulation Of Organ Growth Regulation Of Peptide Hormone Secretion Regulation Of Establishment Of Protein Localization Interleukin-5-mediated Signaling Pathway Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Cellular Response To Interleukin-3 Positive Regulation Of Protein Transport Neutrophil Differentiation Positive Regulation Of Organ Growth Regulation Of Cell Population Proliferation Regulation Of Protein Transport Ventricular Cardiac Muscle Cell Development Positive Regulation Of Protein Localization Growth Hormone Receptor Binding Regulation Of Hormone Secretion Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion Regulation Of Protein Secretion Establishment Of Protein Localization To Plasma Membrane Mitotic Nuclear Membrane Disassembly Regulation Of Protein Localization Positive Regulation Of Cell Population Proliferation Regulation Of Heart Growth Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Nuclear Membrane Disassembly Type II Interferon-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Membrane Disassembly Interleukin-6-mediated Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Establishment Of Protein Localization To Membrane Regulation Of Growth Positive Regulation Of Protein Localization To Nucleus Nuclear Envelope Organization Growth Hormone Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Circadian Rhythm Positive Regulation Of Cardiac Muscle Cell Proliferation Myeloid Cell Differentiation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle	Cytokine-mediated Signaling Pathway Cytokine Receptor Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cytokine Binding Receptor Complex Growth Hormone Receptor Signaling Pathway Via JAK-STAT External Side Of Plasma Membrane Protein Phosphorylation Regulation Of Cell Population Proliferation Response To Cytokine Response To Peptide Signal Transduction Phosphorylation Growth Hormone Receptor Signaling Pathway Plasma Membrane Regulation Of Leukocyte Proliferation Positive Regulation Of Leukocyte Proliferation Interleukin-3-mediated Signaling Pathway Cellular Response To Interleukin-3 Protein Kinase Activity Erythropoietin-mediated Signaling Pathway Extrinsic Component Of Plasma Membrane Interleukin-15-mediated Signaling Pathway Growth Hormone Receptor Binding Interleukin-2-mediated Signaling Pathway Kinase Activity Peptidyl-tyrosine Phosphorylation Protein Tyrosine Kinase Activity Negative Regulation Of Programmed Cell Death Regulation Of Immune System Process Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Diacylglycerol-dependent Serine/threonine Kinase Activity Adaptive Immune Response Interleukin-3 Receptor Activity Histone H3T6 Kinase Activity Regulation Of Receptor Signaling Pathway Via JAK-STAT Intracellular Signal Transduction Leukocyte Activation Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Negative Regulation Of Apoptotic Process Positive Regulation Of Interleukin-17 Production Regulation Of Cell Differentiation Regulation Of Developmental Process Regulation Of Platelet Aggregation Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway
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