IL3RA and C2CD2L

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		IL3RA	C2CD2L
Description		interleukin 3 receptor subunit alpha	C2CD2 like
Image
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Cortical Endoplasmic Reticulum Cytoplasmic Side Of Apical Plasma Membrane Endoplasmic Reticulum-plasma Membrane Contact Site
	Molecular Function	Cytokine Receptor Activity Interleukin-3 Receptor Activity Protein Binding Cytokine Binding	Protein Binding Lipid Binding Phosphatidylinositol Transfer Activity Phosphatidylinositol Binding Insulin Binding
	Biological Process	Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Cellular Response To Interleukin-3 Interleukin-3-mediated Signaling Pathway	Lipid Transport Phospholipid Transport Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Intermembrane Lipid Transfer
Pathways		Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin receptor SHC signaling
Drugs		Sargramostim Tagraxofusp
Diseases
GWAS		Schizophrenia ( 17522711)	Glycated hemoglobin levels ( 34059833) Heel bone mineral density ( 30598549)
Interacting Genes		32 interacting genes: BMP10 C2CD2L CDC25A CDK1 CISH CLDN19 CSF2 CSF2RB EMP3 FOXP1 GIMAP1 GNA12 IL3 JAGN1 JAK1 JAK2 LNX1 NINJ2 NR0B2 PAQR5 PPP1CC SAE1 SERP1 SGK2 SMAGP SYS1 TMEM128 TMEM147 TMEM254 TMEM65 TRARG1 VAMP5	31 interacting genes: AQP6 ARL13B CD79A CHODL CISD2 CLRN1 CPEB2 CXCR3 EBP EPB41 FCER1G GJA8 GJB1 HIBADH IL3RA MUC1 OPRM1 PDZK1IP1 REEP2 REEP4 SDCBP SLC10A6 SLC18A1 SLC61A1 TMEM14B TMEM179B TMEM31 TMEM86B TMEM9 TMPRSS2 TMX2
Entrez ID		3563	9854
HPRD ID		02392	15533
Ensembl ID		ENSG00000185291	ENSG00000172375
Uniprot IDs		P26951	O14523
PDB IDs		4JZJ 5UV8 5UWC 6NMY	5TOD
Enriched GO Terms of Interacting Partners?		Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Granulocyte Macrophage Colony-stimulating Factor Receptor Complex Interleukin-3-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Cell Surface Receptor Signaling Pathway Via JAK-STAT Cytokine-mediated Signaling Pathway Regulation Of Insulin Secretion Positive Regulation Of Insulin Secretion Positive Regulation Of Establishment Of Protein Localization Regulation Of Organ Growth Regulation Of Peptide Hormone Secretion Regulation Of Establishment Of Protein Localization Interleukin-5-mediated Signaling Pathway Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Cellular Response To Interleukin-3 Positive Regulation Of Protein Transport Neutrophil Differentiation Positive Regulation Of Organ Growth Regulation Of Cell Population Proliferation Regulation Of Protein Transport Ventricular Cardiac Muscle Cell Development Positive Regulation Of Protein Localization Growth Hormone Receptor Binding Regulation Of Hormone Secretion Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion Regulation Of Protein Secretion Establishment Of Protein Localization To Plasma Membrane Mitotic Nuclear Membrane Disassembly Regulation Of Protein Localization Positive Regulation Of Cell Population Proliferation Regulation Of Heart Growth Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Nuclear Membrane Disassembly Type II Interferon-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Membrane Disassembly Interleukin-6-mediated Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Establishment Of Protein Localization To Membrane Regulation Of Growth Positive Regulation Of Protein Localization To Nucleus Nuclear Envelope Organization Growth Hormone Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Circadian Rhythm Positive Regulation Of Cardiac Muscle Cell Proliferation Myeloid Cell Differentiation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle	Membrane Endoplasmic Reticulum Membrane Interleukin-3-mediated Signaling Pathway
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