IL1RAP and MC4R

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		IL1RAP	MC4R
Name		interleukin 1 receptor accessory protein	melanocortin 4 receptor
Structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Cell Surface Membrane Synapse Glutamatergic Synapse	Cytoplasm Plasma Membrane Membrane
	Molecular Function	Interleukin-33 Receptor Activity Interleukin-1 Receptor Activity Coreceptor Activity Hydrolase Activity Signaling Receptor Activity NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating	G Protein-coupled Receptor Activity Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Protein Binding Ubiquitin Protein Ligase Binding Neuropeptide Binding
	Biological Process	Immune System Process Inflammatory Response Immune Response Signal Transduction Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-5 Production Positive Regulation Of Interleukin-6 Production Interleukin-33-mediated Signaling Pathway Innate Immune Response Positive Regulation Of Synapse Assembly Protein-containing Complex Assembly Interleukin-1-mediated Signaling Pathway Regulation Of Postsynaptic Density Assembly Trans-synaptic Signaling By Trans-synaptic Complex Synaptic Membrane Adhesion Regulation Of Presynapse Assembly	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Feeding Behavior Regulation Of Metabolic Process Insulin Secretion Response To Food Response To Insulin Positive Regulation Of Bone Resorption Regulation Of Feeding Behavior Regulation Of Eating Behavior Response To Melanocyte-stimulating Hormone
Pathways		None	Peptide ligand-binding receptors G alpha (s) signalling events Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs		None	Bremelanotide Setmelanotide
GWAS		Blood protein levels ( 30072576 ) Longitudinal change in brain amyloid plaque burden ( 26268530 ) Lung cancer ( 18385676 ) Waist circumference ( 20966902 )	Adult body size ( 32376654 ) Antipsychotic drug-induced weight gain ( 22566560 ) Basal metabolic rate ( 31453325 ) Basal metabolic rate variance ( 31453325 ) BMI (adjusted for smoking behaviour) ( 28443625 ) BMI in non-smokers ( 28443625 ) BMI in smokers ( 28443625 ) Body fat percentage ( 26833246 ) Body mass index ( 18454148 19079260 19079261 20935630 23563607 23669352 24064335 24348519 24861553 25673413 25953783 26426971 26961502 28448500 28552196 28892062 29273807 29381148 31453325 ) Body mass index (adult) ( 28430825 ) Body mass index (age <50) ( 26426971 ) Body mass index (age interaction) ( 25953783 ) Body mass index (age>50) ( 26426971 ) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500 ) Body mass index (joint analysis main effects and smoking interaction) ( 28443625 ) Body mass index (SNP x SNP interaction) ( 22344221 ) Body mass index in physically active individuals ( 28448500 ) Body mass index in physically inactive individuals ( 28448500 ) Body mass index variance ( 31453325 ) Body mass index x age interaction ( 26426971 ) Body mass index x sex x age interaction (4df test) ( 26426971 ) Body size at age 10 ( 32376654 ) C-reactive protein levels ( 30388399 ) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809 ) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809 ) Caffeine consumption from coffee ( 33287642 ) Caffeine consumption from coffee or tea ( 33287642 ) Childhood body mass index ( 26604143 33045005 ) Childhood onset type 2 diabetes ( 33479058 ) Cobalt levels ( 26025379 ) Coffee consumption ( 31046077 ) Coffee consumption (cups per day) ( 31837886 ) Coronary artery disease ( 26343387 33020668 ) Daytime sleep phenotypes ( 27126917 ) Dentures ( 31235808 ) Diastolic blood pressure ( 27841878 ) Fat body mass ( 24064335 ) Fatty acid desaturase activity (serum) ( 30453627 ) Femoral neck bone mineral density ( 30172743 ) Free thyroxine concentration ( 30367059 ) Fruit consumption ( 32066663 ) Hand grip strength ( 29691431 ) HDL cholesterol ( 20686565 24097068 ) HDL cholesterol levels ( 28334899 30698716 32203549 ) HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Heel bone mineral density ( 30598549 ) Height ( 20881960 25282103 25429064 31562340 ) Hip circumference ( 25673412 28552196 31453325 ) Hip circumference variance ( 31453325 ) Leg fat mass and leg lean mass (pleiotropy) ( 32719433 ) Leg lean mass (fat adjusted) ( 32719433 ) Metabolic syndrome ( 31589552 ) Myocardial infarction ( 33532862 ) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808 ) Obese vs. thin ( 30677029 ) Obesity ( 19151714 23563607 ) Obesity (early onset extreme) ( 20421936 23563609 ) Obesity (extreme) ( 30677029 ) Obesity-related traits ( 22013104 ) Systolic blood pressure ( 30224653 ) Total body bone mineral density ( 30172743 ) Triglyceride levels ( 32203549 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Type 2 diabetes ( 22885922 24509480 28869590 30054458 30297969 30718926 32499647 ) Ulna and radius bone mineral density ( 30172743 ) Urate levels ( 23263486 31578528 ) Waist circumference ( 19557197 25673412 28552196 31453325 ) Waist circumference and related phenotypes ( 18454146 ) Waist circumference variance ( 31453325 ) Waist-hip ratio ( 25673412 ) Weight ( 19079260 )
Novel Interactors		2 novel interactors: AP2M1 FXR1	None recorded
Interacting Genes		20 interacting genes: CCNI IL18R1 IL1A IL1B IL1R1 IL1R2 IRAK1 KPNA1 MARCHF8 MC4R MYD88 PIK3R1 PRKCI PRPF40A PTPRD RAC1 SIRPA STAT3 TICAM2 TOLLIP	20 interacting genes: AGRP AIG1 ASIP ATP6V0E2 ATRNL1 CD81 GRK2 IL1RAP MAL MC1R NPC1 NPY PDIA6 PLLP POMC PRKACA TMEM19 TMEM94 TSPAN3 YIPF3
Entrez ID		3556	4160
HPRD ID		04021	01116
Ensembl ID		ENSG00000196083	ENSG00000166603
Uniprot IDs		A8K6K4 Q9NPH3	P32245
PDB IDs		3O4O 4DEP 7FCC	6W25 7AUE 7F53 7F54 7F55 7F58 7PIU 7PIV 8QJ2 8WKY 8WKZ
GO Terms Enriched among Interactors		Regulation Of Cytokine Production Cytokine-mediated Signaling Pathway Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 Positive Regulation Of Multicellular Organismal Process Regulation Of Canonical NF-kappaB Signal Transduction Immune Response Positive Regulation Of Cytokine Production Inflammatory Response Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Multicellular Organismal Process Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Interleukin-1 Receptor Activity Immune System Process Regulation Of Tumor Necrosis Factor Production Regulation Of Immune System Process Positive Regulation Of T-helper 1 Cell Cytokine Production Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Immune System Process Defense Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Interleukin-1 Receptor Binding Regulation Of Defense Response Positive Regulation Of Cellular Component Organization Positive Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Regulation Of Interleukin-6 Production Positive Regulation Of T-helper 1 Type Immune Response Response To Lipopolysaccharide Cellular Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cytokine Production Signal Transduction Regulation Of Cytokine Production Involved In Inflammatory Response Response To Cytokine Cellular Response To Molecule Of Bacterial Origin Glutamatergic Synapse Positive Regulation Of Cytokine Production Involved In Immune Response Response To Peptide Fever Generation Positive Regulation Of Transport Positive Regulation Of Interleukin-6 Production Positive Regulation Of T Cell Cytokine Production Negative Regulation Of Multicellular Organismal Process	Adult Feeding Behavior Positive Regulation Of Feeding Behavior Neuropeptide Hormone Activity Positive Regulation Of Behavior Regulation Of Feeding Behavior Type 1 Melanocortin Receptor Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding G Protein-coupled Receptor Signaling Pathway Pigmentation Adult Behavior Structural Constituent Of Myelin Sheath G Protein-coupled Receptor Binding Regulation Of Behavior Melanin Biosynthetic Process Melanin Metabolic Process Feeding Behavior Neuropeptide Signaling Pathway Symbiont Entry Into Host Cell Membrane Chemical Homeostasis Regulation Of Appetite Photoperiodism Membrane Raft Organization Cellular Response To Low-density Lipoprotein Particle Stimulus Negative Regulation Of Relaxation Of Smooth Muscle Biological Process Involved In Interaction With Host Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Signaling Receptor Binding Long-day Photoperiodism Secondary Metabolic Process Melanocortin Receptor Binding Cell Communication Cellular Response To Lipoprotein Particle Stimulus Macrophage Fusion Positive Regulation Of Adaptive Immune Memory Response CD4-positive, Alpha-beta T Cell Costimulation Protein Insertion Into Plasma Membrane Plasma Membrane Raft Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Intracellular Monoatomic Ion Homeostasis Short-day Photoperiodism Intracellular Monoatomic Cation Homeostasis Cyclodextrin Metabolic Process Positive Regulation Of Oxytocin Production P-type Magnesium Transporter Activity Magnesium Ion Transport From Cytosol To Endoplasmic Reticulum Regulation Of Macroautophagy Plasma Membrane Cholesterol Binding