IL1RAP and CCNI

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		IL1RAP	CCNI
Description		interleukin 1 receptor accessory protein	cyclin I
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Cell Surface Membrane Synapse Glutamatergic Synapse	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Cytoplasm Membrane Nuclear Membrane
	Molecular Function	Interleukin-33 Receptor Activity Interleukin-1 Receptor Activity Coreceptor Activity Hydrolase Activity Signaling Receptor Activity NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
	Biological Process	Immune System Process Inflammatory Response Immune Response Signal Transduction Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-5 Production Positive Regulation Of Interleukin-6 Production Interleukin-33-mediated Signaling Pathway Innate Immune Response Positive Regulation Of Synapse Assembly Protein-containing Complex Assembly Interleukin-1-mediated Signaling Pathway Regulation Of Postsynaptic Density Assembly Trans-synaptic Signaling By Trans-synaptic Complex Synaptic Membrane Adhesion Regulation Of Presynapse Assembly	G1/S Transition Of Mitotic Cell Cycle Spermatogenesis
Pathways
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Longitudinal change in brain amyloid plaque burden ( 26268530) Lung cancer ( 18385676) Waist circumference ( 20966902)
Interacting Genes		20 interacting genes: CCNI IL18R1 IL1A IL1B IL1R1 IL1R2 IRAK1 KPNA1 MARCHF8 MC4R MYD88 PIK3R1 PRKCI PRPF40A PTPRD RAC1 SIRPA STAT3 TICAM2 TOLLIP	10 interacting genes: AKT1 CDC25A CDK3 CDK6 CEP63 IL1RAP KRT18 MSRA RND1 ZMYND19
Entrez ID		3556	10983
HPRD ID		04021	16690
Ensembl ID		ENSG00000196083	ENSG00000118816
Uniprot IDs		A8K6K4 Q9NPH3	Q14094
PDB IDs		3O4O 4DEP 7FCC
Enriched GO Terms of Interacting Partners?		Regulation Of Cytokine Production Cytokine-mediated Signaling Pathway Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 Positive Regulation Of Multicellular Organismal Process Regulation Of Canonical NF-kappaB Signal Transduction Immune Response Positive Regulation Of Cytokine Production Inflammatory Response Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Multicellular Organismal Process Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Interleukin-1 Receptor Activity Immune System Process Regulation Of Tumor Necrosis Factor Production Regulation Of Immune System Process Positive Regulation Of T-helper 1 Cell Cytokine Production Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Immune System Process Defense Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Interleukin-1 Receptor Binding Regulation Of Defense Response Positive Regulation Of Cellular Component Organization Positive Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Regulation Of Interleukin-6 Production Positive Regulation Of T-helper 1 Type Immune Response Response To Lipopolysaccharide Cellular Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cytokine Production Signal Transduction Regulation Of Cytokine Production Involved In Inflammatory Response Response To Cytokine Cellular Response To Molecule Of Bacterial Origin Glutamatergic Synapse Positive Regulation Of Cytokine Production Involved In Immune Response Response To Peptide Fever Generation Positive Regulation Of Transport Positive Regulation Of Interleukin-6 Production Positive Regulation Of T Cell Cytokine Production Negative Regulation Of Multicellular Organismal Process	Regulation Of Cell Cycle Phase Transition Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Mitotic Cell Cycle Phase Transition Cell Division Cell Cycle Phase Transition Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Mitotic Cell Cycle Cyclin Binding Regulation Of Cell Cycle Golgi To Plasma Membrane Protein Transport Negative Regulation Of Notch Signaling Pathway Cyclin-dependent Protein Kinase Holoenzyme Complex Establishment Of Protein Localization To Plasma Membrane Regulation Of TRNA Methylation Golgi To Plasma Membrane Transport Cyclin D2-CDK6 Complex L-methionine:thioredoxin-disulfide S-oxidoreductase Activity Peptide-methionine (S)-S-oxide Reductase Activity L-methionine-(S)-S-oxide Reductase Activity Negative Regulation Of Protein Ubiquitination Cellular Response To Stress Protein Serine Kinase Activity Negative Regulation Of Protein Localization To Lysosome Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Interleukin-33 Receptor Activity Negative Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Localization To Endoplasmic Reticulum Cytokine-mediated Signaling Pathway Regulation Of Notch Signaling Pathway Post-Golgi Vesicle-mediated Transport Response To Insulin-like Growth Factor Stimulus Positive Regulation Of Mitotic Cell Cycle Phase Transition Mammalian Oogenesis Stage TRNA (guanine-N7)-methylation Cellular Response To Rapamycin Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Protein Serine/threonine Kinase Activity Positive Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle Positive Regulation Of Cell Cycle Phase Transition Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Protein Kinase Binding TORC2 Complex Binding
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