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IL1RAP
Description
interleukin 1 receptor accessory protein
Image
GO Annotations
Cellular Component
Extracellular Region
Plasma Membrane
Cell Surface
Membrane
Synapse
Glutamatergic Synapse
Molecular Function
Interleukin-33 Receptor Activity
Interleukin-1 Receptor Activity
Coreceptor Activity
Hydrolase Activity
Signaling Receptor Activity
NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating
Biological Process
Immune System Process
Inflammatory Response
Immune Response
Signal Transduction
Cytokine-mediated Signaling Pathway
Positive Regulation Of Interleukin-13 Production
Positive Regulation Of Interleukin-4 Production
Positive Regulation Of Interleukin-5 Production
Positive Regulation Of Interleukin-6 Production
Interleukin-33-mediated Signaling Pathway
Innate Immune Response
Positive Regulation Of Synapse Assembly
Protein-containing Complex Assembly
Interleukin-1-mediated Signaling Pathway
Regulation Of Postsynaptic Density Assembly
Trans-synaptic Signaling By Trans-synaptic Complex
Synaptic Membrane Adhesion
Regulation Of Presynapse Assembly
Pathways
Drugs
Diseases
GWAS
Blood protein levels (
30072576
)
Longitudinal change in brain amyloid plaque burden (
26268530
)
Lung cancer (
18385676
)
Waist circumference (
20966902
)
Novel Interacting Genes
2 novel interacting genes:
AP2M1
FXR1
Interacting Genes
20 interacting genes:
CCNI
IL18R1
IL1A
IL1B
IL1R1
IL1R2
IRAK1
KPNA1
MARCHF8
MC4R
MYD88
PIK3R1
PRKCI
PRPF40A
PTPRD
RAC1
SIRPA
STAT3
TICAM2
TOLLIP
Entrez ID
3556
HPRD ID
04021
Ensembl ID
ENSG00000196083
Uniprot IDs
A8K6K4
Q9NPH3
PDB IDs
3O4O
4DEP
7FCC
Enriched GO Terms of Interacting Partners
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Regulation Of Cytokine Production
Cytokine-mediated Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Response To Interleukin-1
Positive Regulation Of Multicellular Organismal Process
Regulation Of Canonical NF-kappaB Signal Transduction
Immune Response
Positive Regulation Of Cytokine Production
Inflammatory Response
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Multicellular Organismal Process
Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Interleukin-1 Receptor Activity
Immune System Process
Regulation Of Tumor Necrosis Factor Production
Regulation Of Immune System Process
Positive Regulation Of T-helper 1 Cell Cytokine Production
Positive Regulation Of Signal Transduction
Cell Surface Receptor Signaling Pathway
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Immune System Process
Defense Response
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Interleukin-1 Receptor Binding
Regulation Of Defense Response
Positive Regulation Of Cellular Component Organization
Positive Regulation Of Gene Expression
Regulation Of Intracellular Signal Transduction
Regulation Of Interleukin-6 Production
Positive Regulation Of T-helper 1 Type Immune Response
Response To Lipopolysaccharide
Cellular Response To Lipopolysaccharide
Response To Molecule Of Bacterial Origin
Positive Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Cytokine Production
Signal Transduction
Regulation Of Cytokine Production Involved In Inflammatory Response
Response To Cytokine
Cellular Response To Molecule Of Bacterial Origin
Glutamatergic Synapse
Positive Regulation Of Cytokine Production Involved In Immune Response
Response To Peptide
Fever Generation
Positive Regulation Of Transport
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of T Cell Cytokine Production
Negative Regulation Of Multicellular Organismal Process
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