IL1RAP and IL1R2

Number of citations of the paper that reports this interaction (PubMedID 9862719)
0

Data Source:
HPRD (in vivo)

		IL1RAP	IL1R2
Description		interleukin 1 receptor accessory protein	interleukin 1 receptor type 2
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Cell Surface Membrane Synapse Glutamatergic Synapse	Extracellular Region Cytoplasm Plasma Membrane Cell Surface Membrane
	Molecular Function	Interleukin-33 Receptor Activity Interleukin-1 Receptor Activity Coreceptor Activity Hydrolase Activity Signaling Receptor Activity NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating	Interleukin-1 Receptor Activity Interleukin-1, Type II, Blocking Receptor Activity Protein Binding Interleukin-1 Binding
	Biological Process	Immune System Process Inflammatory Response Immune Response Signal Transduction Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-5 Production Positive Regulation Of Interleukin-6 Production Interleukin-33-mediated Signaling Pathway Innate Immune Response Positive Regulation Of Synapse Assembly Protein-containing Complex Assembly Interleukin-1-mediated Signaling Pathway Regulation Of Postsynaptic Density Assembly Trans-synaptic Signaling By Trans-synaptic Complex Synaptic Membrane Adhesion Regulation Of Presynapse Assembly	Immune Response Cell Surface Receptor Signaling Pathway Negative Regulation Of Protein Processing Protein Processing Cytokine-mediated Signaling Pathway Negative Regulation Of Interleukin-1 Alpha Production Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Interleukin-1-mediated Signaling Pathway
Pathways			Interleukin-10 signaling Interleukin-1 signaling
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Longitudinal change in brain amyloid plaque burden ( 26268530) Lung cancer ( 18385676) Waist circumference ( 20966902)	Ankylosing spondylitis ( 20062062 23749187) Asthma ( 31619474) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood protein levels ( 30072576) C-reactive protein levels ( 30388399) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422) Inflammatory bowel disease ( 23128233 28067908) Parkinson's disease ( 28892059 32201043) Ulcerative colitis ( 21297633)
Interacting Genes		20 interacting genes: CCNI IL18R1 IL1A IL1B IL1R1 IL1R2 IRAK1 KPNA1 MARCHF8 MC4R MYD88 PIK3R1 PRKCI PRPF40A PTPRD RAC1 SIRPA STAT3 TICAM2 TOLLIP	5 interacting genes: IL1A IL1B IL1RAP IL1RN USP15
Entrez ID		3556	7850
HPRD ID		04021	00995
Ensembl ID		ENSG00000196083	ENSG00000115590
Uniprot IDs		A8K6K4 Q9NPH3	P27930
PDB IDs		3O4O 4DEP 7FCC	3O4O
Enriched GO Terms of Interacting Partners?		Regulation Of Cytokine Production Cytokine-mediated Signaling Pathway Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 Positive Regulation Of Multicellular Organismal Process Regulation Of Canonical NF-kappaB Signal Transduction Immune Response Positive Regulation Of Cytokine Production Inflammatory Response Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Multicellular Organismal Process Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Interleukin-1 Receptor Activity Immune System Process Regulation Of Tumor Necrosis Factor Production Regulation Of Immune System Process Positive Regulation Of T-helper 1 Cell Cytokine Production Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Immune System Process Defense Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Interleukin-1 Receptor Binding Regulation Of Defense Response Positive Regulation Of Cellular Component Organization Positive Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Regulation Of Interleukin-6 Production Positive Regulation Of T-helper 1 Type Immune Response Response To Lipopolysaccharide Cellular Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cytokine Production Signal Transduction Regulation Of Cytokine Production Involved In Inflammatory Response Response To Cytokine Cellular Response To Molecule Of Bacterial Origin Glutamatergic Synapse Positive Regulation Of Cytokine Production Involved In Immune Response Response To Peptide Fever Generation Positive Regulation Of Transport Positive Regulation Of Interleukin-6 Production Positive Regulation Of T Cell Cytokine Production Negative Regulation Of Multicellular Organismal Process	Interleukin-1 Receptor Binding Acute-phase Response Fever Generation Acute Inflammatory Response Positive Regulation Of Immature T Cell Proliferation In Thymus Heat Generation Positive Regulation Of Interleukin-6 Production Regulation Of Immature T Cell Proliferation In Thymus Inflammatory Response Regulation Of Interleukin-6 Production Ectopic Germ Cell Programmed Cell Death Programmed Cell Death Involved In Cell Development Cytokine Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Interleukin-1-mediated Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Production Temperature Homeostasis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Interleukin-2 Production Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Mitotic Nuclear Division Immune Response Regulation Of Apoptotic Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Interleukin-2 Production Defense Response Negative Regulation Of Signal Transduction Positive Regulation Of Cytokine Production Positive Regulation Of Cell Division Negative Regulation Of Cell Communication Regulation Of Cell-cell Adhesion Negative Regulation Of Signaling Positive Regulation Of Cell Adhesion Molecule Production Interleukin-1 Type I Receptor Antagonist Activity Interleukin-1 Type II Receptor Antagonist Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of T Cell Proliferation Extrinsic Apoptotic Signaling Pathway Regulation Of Mitotic Nuclear Division Negative Regulation Of Gap Junction Assembly Interleukin-33 Receptor Activity Interleukin-1, Type II Receptor Binding Interleukin-1, Type I Receptor Binding Negative Regulation Of Antifungal Innate Immune Response Immune System Process Regulation Of Nuclear Division Positive Regulation Of Lymphocyte Proliferation
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