APP and PSEN1

Number of citations of the paper that reports this interaction (PMID 10593990)
51

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (in vitro)

		APP	PSEN1
Gene Name		amyloid beta (A4) precursor protein	presenilin 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nuclear Envelope Lumen Cytoplasm Endosome Golgi Apparatus Cytosol Plasma Membrane Integral Component Of Plasma Membrane Coated Pit Cell-cell Junction Cell Surface Integral Component Of Membrane ER To Golgi Transport Vesicle Axon Platelet Alpha Granule Lumen Neuromuscular Junction Ciliary Rootlet Dendritic Spine Dendritic Shaft Intracellular Membrane-bounded Organelle Receptor Complex Membrane Raft Apical Part Of Cell Synapse Perinuclear Region Of Cytoplasm Spindle Midzone Extracellular Vesicular Exosome	Golgi Membrane Kinetochore Nuclear Outer Membrane Mitochondrion Mitochondrial Inner Membrane Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Centrosome Integral Component Of Plasma Membrane Cell Cortex Cell Surface Membrane Integral Component Of Membrane Apical Plasma Membrane Z Disc Axon Growth Cone Cytoplasmic Vesicle Neuromuscular Junction Nuclear Membrane Ciliary Rootlet Neuronal Cell Body Dendritic Shaft Membrane Raft Perinuclear Region Of Cytoplasm Gamma-secretase Complex
	Molecular Function	DNA Binding Serine-type Endopeptidase Inhibitor Activity Receptor Binding Protein Binding Heparin Binding Peptidase Activator Activity Enzyme Binding Acetylcholine Receptor Binding Identical Protein Binding Transition Metal Ion Binding PTB Domain Binding Growth Factor Receptor Binding	Endopeptidase Activity Aspartic-type Endopeptidase Activity Calcium Channel Activity Protein Binding Beta-catenin Binding PDZ Domain Binding Cadherin Binding
	Biological Process	Suckling Behavior Platelet Degranulation MRNA Polyadenylation Regulation Of Translation Protein Phosphorylation Cellular Copper Ion Homeostasis Endocytosis Response To Oxidative Stress Cell Adhesion Regulation Of Epidermal Growth Factor-activated Receptor Activity Notch Signaling Pathway Axonogenesis Blood Coagulation Mating Behavior Locomotory Behavior Axon Cargo Transport Cholesterol Metabolic Process Adult Locomotory Behavior Visual Learning Negative Regulation Of Endopeptidase Activity Positive Regulation Of Peptidase Activity Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Axon Midline Choice Point Recognition Neuron Remodeling Dendrite Development Platelet Activation Extracellular Matrix Organization Forebrain Development Neuron Projection Development Ionotropic Glutamate Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Multicellular Organism Growth Regulation Of Protein Binding Innate Immune Response Negative Regulation Of Neuron Differentiation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Collateral Sprouting In Absence Of Injury Regulation Of Synapse Structure Or Activity Neuromuscular Process Controlling Balance Synaptic Growth At Neuromuscular Junction Neuron Apoptotic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis	Autophagic Vacuole Assembly Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of MAPKK Activity Blood Vessel Development Cell Fate Specification Somitogenesis Neuron Migration Positive Regulation Of Receptor Recycling Heart Looping Hematopoietic Progenitor Cell Differentiation T Cell Activation Involved In Immune Response Protein Glycosylation Membrane Protein Ectodomain Proteolysis Mitochondrial Transport Cellular Response To DNA Damage Stimulus Response To Oxidative Stress Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Notch Signaling Pathway Notch Receptor Processing Memory Post-embryonic Development Protein Transport L-glutamate Transport Choline Transport Synaptic Vesicle Targeting Single Organismal Cell-cell Adhesion Protein Processing Cerebral Cortex Cell Migration Cajal-Retzius Cell Differentiation Dorsal/ventral Neural Tube Patterning Extracellular Matrix Disassembly Extracellular Matrix Organization Embryonic Limb Morphogenesis Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Calcium Ion Homeostasis Beta-amyloid Formation Intracellular Signal Transduction Regulation Of Phosphorylation Amyloid Precursor Protein Catabolic Process Myeloid Dendritic Cell Differentiation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Regulation Of Protein Binding Positive Regulation Of MAP Kinase Activity Negative Regulation Of Neuron Apoptotic Process Skin Morphogenesis Regulation Of Synaptic Plasticity Thymus Development Neuron Development Skeletal System Morphogenesis Brain Morphogenesis Beta-amyloid Metabolic Process Epithelial Cell Proliferation Negative Regulation Of Axonogenesis Positive Regulation Of Coagulation T Cell Receptor Signaling Pathway Neuron Apoptotic Process Negative Regulation Of Ubiquitin-protein Transferase Activity Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Synaptic Transmission, Glutamatergic Canonical Wnt Signaling Pathway Regulation Of Resting Membrane Potential Calcium Ion Transmembrane Transport Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Signaling by GPCR Platelet degranulation Metabolic disorders of biological oxidation enzymes RIP-mediated NFkB activation via ZBP1 Formyl peptide receptors bind formyl peptides and many other ligands Amyloids Toll Like Receptor TLR1:TLR2 Cascade Peptide ligand-binding receptors Toll Like Receptor 5 (TLR5) Cascade The NLRP3 inflammasome Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade G alpha (i) signalling events TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade G alpha (q) signalling events GPCR downstream signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Platelet activation, signaling and aggregation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Class A/1 (Rhodopsin-like receptors) Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Activated TLR4 signalling MyD88 cascade initiated on plasma membrane ZBP1(DAI) mediated induction of type I IFNs ECM proteoglycans MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Advanced glycosylation endproduct receptor signaling Innate Immune System Inflammasomes Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade GPCR ligand binding Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TRAF6 mediated NF-kB activation	Degradation of the extracellular matrix
Drugs
Diseases
GWAS
Protein-Protein Interactions		1995 interactors: A2M AAK1 AAMDC ABCB7 ABCF1 ABHD10 ABHD11 ABL1 ABLIM1 ABR ACAA2 ACAD10 ACAD11 ACBD4 ACBD6 ACHE ACKR2 ACLY ACO1 ACO2 ACSBG1 ACSL3 ACSL4 ACTL6B ACTL7A ACTL7B ACTR1B ACY1 ACYP1 ADAD2 ADAP2 ADARB1 ADAT2 ADD2 ADH4 ADH5 ADI1 ADRM1 AEBP2 AFAP1L2 AFG3L1P AFG3L2 AGAP1 AGER AGFG1 AGFG2 AGO4 AGPAT3 AGR2 AHDC1 AHSA1 AICDA AIDA AIFM3 AIMP1 AIMP2 AK1 AK4 AKAP1 AKNAD1 AKT1 AKT2 ALB ALDH2 ALDH4A1 ALDH7A1 ALDH8A1 ALDOB ALKBH7 ALOX5 AMOT ANGPTL7 ANKRA2 ANKRD13D ANKRD36BP1 ANKRD39 ANKRD45 ANKRD50 ANKS1B ANKS4B ANKS6 ANKZF1 ANP32B ANXA2 ANXA5 ANXA8 ANXA9 AP1M2 AP2A2 AP4S1 APBA1 APBA2 APBA3 APBB1 APBB2 APBB3 APEX1 APEX2 APITD1 APLF APOA1 APOBEC3G APOE APPBP2 APRT ARAP1 ARCN1 AREG ARF6 ARFGAP1 ARFGAP3 ARFIP2 ARGLU1 ARHGAP17 ARHGAP24 ARHGAP9 ARHGDIB ARHGEF40 ARHGEF5 ARID3A ARID3B ARL4C ARL4D ARL5A ARL6IP6 ARL8B ARMC1 ARMC7 ARMC9 ARMCX3 ARNT2 ARPC1B ARPP19 ARRDC1 ART4 ASB6 ASCL3 ASGR1 ASMTL ASPH ASPSCR1 ASS1 ASXL1 ASXL2 ATAT1 ATCAY ATF2 ATF4 ATF6 ATG12 ATG13 ATG16L1 ATG7 ATL3 ATP5A1 ATP5C1 ATP5H ATP6V1E1 ATP6V1G1 ATPAF2 ATRAID ATXN3 AURKA AURKB AVPI1 BAALC-AS2 BACE1 BACE2 BAIAP2 BBX BCAP31 BCAR3 BCAT2 BCKDK BCL11A BCL2A1 BCL2L11 BCL2L13 BCL7C BDH1 BDNF BEGAIN BEND2 BEND5 BET1L BGN BHLHB9 BHMT2 BIK BIN1 BIN3-IT1 BLMH BLOC1S1 BLOC1S2 BLOC1S5 BLOC1S6 BMPR1B BMX BNIP1 BOD1 BOLA1 BRD3 BRF1 BRMS1 BRWD1 BSND BTF3 BTK BUD31 BYSL C10orf88 C11orf45 C11orf52 C11orf53 C11orf54 C11orf63 C11orf71 C11orf73 C12orf5 C12orf65 C14orf159 C14orf93 C15orf39 C15orf43 C16orf70 C17orf70 C17orf85 C18orf21 C19orf12 C19orf18 C19orf33 C19orf40 C19orf43 C19orf57 C1D C1orf105 C1orf110 C1orf111 C1orf112 C1orf115 C1orf131 C1orf174 C1orf35 C1orf64 C1orf87 C21orf33 C21orf59 C22orf46 C2orf47 C2orf49 C2orf57 C3orf20 C3orf33 C3orf36 C3orf62 C4orf22 C4orf46 C5orf15 C5orf28 C6orf106 C6orf118 C6orf201 C6orf203 C7orf31 C7orf50 C8orf33 C9orf142 C9orf41 C9orf43 C9orf72 C9orf78 CAAP1 CACNB1 CACNG2 CACNG3 CALCOCO1 CALR CAMK1 CAMK1D CAMKK1 CAMKK2 CAMKMT CAMKV CAPNS2 CAPRIN1 CAPSL CARF CARS CASC4 CASP3 CASP4 CASP6 CASP8 CASZ1 CAT CATIP CAV1 CBFA2T2 CCBL1 CCDC106 CCDC107 CCDC115 CCDC14 CCDC144NL CCDC149 CCDC15 CCDC28B CCDC33 CCDC40 CCDC59 CCDC60 CCDC88C CCIN CCL13 CCL26 CCNB1IP1 CCNB3 CCND3 CCNE2 CCNG1 CCNL1 CCSER2 CCT7 CCT8 CCZ1B CD300LB CD300LF CD36 CD58 CD74 CDC20 CDC25A CDC37 CDC42EP4 CDC7 CDCA3 CDCA7 CDIPT CDK16 CDK17 CDK18 CDK2AP2 CDK3 CDK4 CDK5 CDK5R1 CDK7 CDKL2 CDKL3 CDKN1A CDKN2B CDKN2D CDPF1 CEACAM6 CELF1 CELF2 CELF4 CENPB CENPI CENPQ CENPT CEP250 CEP57 CERK CFAP53 CFAP58 CFDP1 CFHR2 CFL1 CGB CHAC2 CHAF1B CHCHD6 CHEK1 CHEK2 CHGB CHID1 CHKA CHMP3 CHRAC1 CHRNA7 CHTOP CHURC1 CIAO1 CIART CINP CIRBP CIRH1A CISD2 CLASRP CLDN16 CLDN20 CLDN3 CLEC2B CLEC3B CLIC3 CLIP4 CLK3 CLP1 CLU CLUAP1 CMAS CMTM2 CMTM3 CNDP1 CNOT7 CNPY2 COA5 COASY COIL COL14A1 COL1A2 COL25A1 COL4A1 COL4A2 COL4A3 COL4A5 COL4A6 COLEC12 COMMD2 COPB1 COPS7B COPZ1 COQ6 COX4I1 COX4I2 COX6A2 CPEB1 CPLX2 CRACR2B CRADD CRHR2 CRIP2 CRYAB CSAG1 CSNK1D CSNK1E CSNK1G1 CSNK1G2 CSNK2A1 CSRP1 CST2 CSTF2 CTBP2 CTF1 CTNNA1 CTNNB1 CTNND1 CTSB CTSD CUL3 CUL4B CWC15 CWF19L2 CXCL14 CXCL16 CXorf56 CXXC4 CYB561D2 CYB5B CYP20A1 DAB1 DAB2 DAPK2 DCAF7 DCDC2 DCLK1 DCTN6 DCTPP1 DCUN1D2 DCX DCXR DDHD2 DDRGK1 DDX1 DDX10 DDX17 DDX18 DDX19B DDX20 DDX42 DDX43 DDX47 DDX54 DDX55 DECR1 DECR2 DEDD DEF6 DEFA6 DENND1C DENND6B DEPTOR DERL1 DFFB DGCR6 DGCR8 DGUOK DHRS7B DHRSX DHX16 DHX58 DIDO1 DIEXF DIMT1 DIO3 DIRAS1 DIXDC1 DKFZP434K028 DLGAP1-AS2 DLGAP5 DLK2 DMD DMKN DMTN DNAAF2 DNAH14 DNAJB1 DNAJB14 DNAJB6 DNAJC12 DNAJC19 DNAJC4 DNAJC8 DNALI1 DNM2 DPCD DPCR1 DPP3 DPY19L2P1 DPY19L2P4 DRAM1 DRAP1 DSCR9 DSN1 DTD2 DTWD1 DUS3L DUSP12 DUSP21 DUSP3 DUSP4 DYNC1LI2 DYNLRB2 DYNLT1 DYRK1A DYRK2 DZIP1L E2F6 E2F8 EAF1 EBF4 EBP ECH1 ECHDC1 ECHDC2 ECI1 ECI2 ECSIT EEF1B2 EEPD1 EFHD2 EFS EIF1 EIF1AX EIF2A EIF2B2 EIF2B5 EIF2S2 EIF3F EIF3G EIF3M EIF4E EIF4E2 EIF5 EIF6 ELF2 ELK1 ELK3 EMC8 EME1 EMG1 ENKD1 ENO3 ENTHD2 ENY2 EOGT EP400NL EPB41 EPB41L1 EPB41L2 EPB41L4A EPB41L5 EPHA2 EPHB4 EPS8L2 ERC1 ERG ERH ERMN ERVFRD-1 ESRRG ETFB ETHE1 ETNPPL ETS1 ETV3 ETV4 ETV5 EVI2A EXOC3 EXOC6 EXOSC1 EXOSC3 EXOSC7 F12 FAAH2 FAM114A2 FAM122A FAM126B FAM127A FAM127B FAM131C FAM133B FAM134B FAM151A FAM160B2 FAM184A FAM19A4 FAM200A FAM212A FAM212B FAM213A FAM214B FAM32A FAM3A FAM3B FAM47B FAM50A FAM53A FAM64A FAM90A1 FANCI FANCM FBF1 FBLN1 FBXL7 FBXO38 FBXW9 FCGR3A FCHO1 FDX1L FEN1 FERMT2 FERMT3 FGF12 FGF16 FGFBP2 FGFR2 FHL2 FIBP FILIP1 FIP1L1 FITM1 FKBP1A FKBP5 FKBPL FLCN FLOT1 FLOT2 FMNL1 FMNL2 FMNL3 FN3KRP FNDC3A FOS FOXI1 FOXJ2 FOXS1 FRG1B FRMD8 FSD1L FSIP1 FTSJ1 FUBP3 FUCA1 FYCO1 G3BP1 GABARAPL2 GABPA GABRA4 GADD45G GADD45GIP1 GAGE1 GAK GAL3ST1 GALE GALK1 GALNT12 GAPDH GAPDHS GAS2 GBA2 GCC1 GEMIN8 GFAP GGA1 GGA2 GGCT GIMAP4 GIMAP5 GIMAP6 GIMAP8 GJB1 GLB1L GLOD4 GLRX5 GNA12 GNA15 GNAT2 GNAZ GNB5 GNL2 GNLY GNPTAB GNRH2 GOLGA4 GORAB GORASP2 GOSR1 GOSR2 GPAM GPANK1 GPATCH1 GPC1 GPKOW GPN2 GPR12 GPR61 GPR78 GPT2 GRAMD4 GRB10 GRB2 GRHL2 GSDMB GSK3B GSN GSPT2 GSTA1 GSTA3 GSTO1 GTDC1 GTF2E1 GTF2E2 GTF3C6 GTPBP1 GTPBP8 GUCD1 GUCY1B3 GYG2 GYS1 H1F0 H2AFV H2AFY HADH HADHB HAGH HAPLN1 HAUS6 HAUS8 HAVCR2 HBD HBG1 HBG2 HBS1L HBZ HCFC1R1 HCK HCP5 HDAC4 HDDC3 HELLS HERC2P9 HERPUD1 HEYL HGS HIC2 HIGD2A HINT2 HINT3 HIRIP3 HIST1H2BA HIST1H2BB HIST1H2BM HIST1H4I HIST2H2AA3 HIST2H2AB HK1 HMBOX1 HMBS HMCES HMG20B HMGB2 HMGB4 HMGCS2 HMOX2 HNRNPA1 HOMER2 HOMER3 HOXB7 HOXC6 HP1BP3 HPGD HRASLS HRASLS5 HS3ST1 HSD17B10 HSPA2 HSPA9 HSPB7 HSPBP1 HSPD1 HSPG2 HTRA2 HYPK IARS IARS2 ICAM3 ICK ICT1 IDE IDO1 IER3 IFI16 IFI6 IFIH1 IFNA16 IFNA5 IFNA8 IFNW1 IFRD2 IFT81 IGBP1 IGF1R IGHM IGSF10 IGSF6 IK IKBIP IL15 IL18RAP IL1B IL1RL1 IL26 IL7 IMP4 ING2 ING3 INIP INPP5B INS INTS12 INTS3 IPO4 IPO9 IQCH IREB2 IRF2 IRGC IRS1 ISL1 ISOC2 ITGA6 ITGB1BP1 ITGB3BP ITM2B JAGN1 JTB JUN KANSL2 KAT5 KAT7 KCNAB1 KCNAB3 KCNE5 KCNIP4 KCNJ10 KCNK5 KCNMB2 KCNN3 KCTD18 KIAA0513 KIAA0825 KIAA0930 KIAA1143 KIAA1191 KIAA1841 KIF2C KIF3A KIF3B KIF4A KIFC1 KIFC3 KIR2DL3 KISS1 KLC1 KLC2 KLC4 KLF12 KLF4 KLF6 KLF7 KLF8 KLHL32 KLK2 KLK7 KLK9 KNG1 KPNA2 KPNA4 KPTN KRAS KRT36 KRTAP10-7 KRTCAP2 L3MBTL4 LACRT LAD1 LAIR1 LAMA1 LAMC1 LANCL2 LAP3 LARP1B LARP4 LARP6 LARP7 LATS1 LCP2 LDLRAP1 LENG1 LETM2 LETMD1 LFNG LGALS2 LGALS3 LIG3 LIMA1 LIMCH1 LIMD1 LIMK1 LIMS2 LIN7A LINC00341 LINC00663 LINC00982 LINGO2 LIPT1 LLPH LMAN1 LMCD1 LMNTD1 LMX1B LNX1 LOC142937 LOC254896 LOC401068 LOC403312 LOC541472 LOC554207 LOC554223 LOC90768 LPAR3 LPL LRP1 LRP1B LRP2 LRRC1 LRRC42 LRRC59 LRRC8D LSM6 LSMEM1 LSMEM2 LUC7L2 LURAP1L LY86 LYPLA2 LYRM7 MAB21L2 MAD2L1 MAG MAGEA4 MAGEH1 MAK MAP1LC3A MAP2 MAP2K3 MAP2K4 MAP3K11 MAPK10 MAPK11 MAPK13 MAPK7 MAPK8 MAPK8IP1 MAPK8IP2 MAPKAPK3 MAPRE1 MAPRE2 MAPT MARCH10 MARCH3 MARS2 MAST1 MAST2 MAT2B MB MBD1 MBNL1 MCC MCEE MCFD2 MCM10 MCM2 MCM5 MCM7 MCTP2 MDM2 MDM4 MED11 MED19 MED24 MED30 MED8 MED9 MEF2D MEIS2 MEOX1 MESDC2 MEST METAP2 METTL16 METTL25 METTL2B METTL8 MICU1 MIER1 MINA MITF MKKS MKNK1 MLLT3 MLLT6 MLX MMGT1 MMP12 MND1 MOB1A MOB1B MOB3A MOB3C MOBP MOGAT3 MORF4L1 MPG MPI MPP3 MPV17L MRAP2 MROH8 MRPL1 MRPL10 MRPL11 MRPL19 MRPL20 MRPL24 MRPL27 MRPL28 MRPL3 MRPL34 MRPL35 MRPL48 MRPL49 MRPL52 MRPL53 MRPS18A MRPS2 MRPS24 MRPS6 MRRF MS4A2 MSI1 MSL3 MSMB MSTN MTCP1 MTERF3 MTERF4 MTFMT MTG1 MTMR14 MTURN MURC MVB12A MX1 MXD1 MXI1 MYBBP1A MYL1 MYL10 MYL5 MYOT MYOZ1 MZT2A NAA25 NAAA NAALADL2 NAE1 NAGA NAPA NAPG NARF NARFL NAT2 NAT6 NAV1 NBPF3 NCSTN NDEL1 NDP NDUFA2 NDUFA4 NDUFA5 NDUFAF7 NDUFB1 NDUFB3 NDUFB6 NDUFS2 NDUFS4 NECAB1 NECAB3 NECAP1 NECAP2 NEDD9 NEIL1 NEK11 NELFA NF1 NFKBIB NFYA NGLY1 NID1 NIM1K NKIRAS1 NLN NLRP2 NME3 NME6 NME8 NMNAT1 NMNAT2 NMRK1 NMRK2 NMT2 NNAT NNMT NOB1 NOC2L NOL11 NOL12 NOL7 NOLC1 NOP16 NOS1AP NOS3 NOVA1 NPL NPM1 NR1D1 NR1H3 NRIP1 NSRP1 NTM NTMT1 NTRK3 NUAK1 NUAK2 NUDT16L1 NUDT16P1 NUDT9 NUMB NUMBL NUP50 NUP62CL NUSAP1 NXF2 NXPE3 NXT2 OARD1 OAS2 OBFC1 OCEL1 OCIAD2 ODAM ODF2 ODF2L ODF4 OLFM1 OLFM3 OLFM4 OLFML2A OPA1 OPA3 OR2W1 OR4D6 OR7A5 ORC3 ORC4 ORC6 ORMDL1 ORMDL3 OSBPL11 OSBPL5 OSM OSTCP1 OSTF1 OTUB2 OTX2 OXSM OXSR1 P2RX6 P2RY2 PABPC3 PACRG PADI4 PAEP PAGR1 PAIP2 PAK1 PAK2 PAK4 PAK6 PAPSS2 PARD6B PARP15 PARP3 PARVA PARVG PASD1 PATL1 PAXIP1 PBRM1 PCBD1 PCBD2 PCBP1 PCDHA7 PCDHGA12 PCDHGC3 PCDHGC5 PCIF1 PCK1 PCK2 PCYT1B PDAP1 PDCD7 PDDC1 PDE1A PDE4D PDE6H PDIA3 PDK3 PDPK1 PDS5B PDSS2 PDYN PDZD4 PDZD9 PDZK1 PELI3 PEX2 PFKFB1 PFKL PGM1 PGM3 PHACTR4 PHF20L1 PHF7 PHF8 PHGDH PHLDA1 PHLDA3 PHYH PHYHD1 PI4K2A PIBF1 PIGG PIGO PIK3R2 PIK3R5 PIKFYVE PIM1 PIN1 PIP4K2C PIP5K1A PKM PKNOX1 PLA1A PLA2G4C PLA2G4D PLBD1 PLCD1 PLCD4 PLEKHF2 PLEKHG2 PLEKHJ1 PLEKHO2 PLIN3 PLK1 PLK2 PLRG1 PLS3 PLSCR1 PNKD PNKP PNMAL1 PNPO POGK POGZ POLA2 POLD3 POLDIP2 POLE3 POLH POLI POLL POLR2F POLR2K POLR3C POMC POMGNT2 POMZP3 POP7 POU2F1 PP2D1 PPAN PPAP2B PPARG PPFIBP2 PPHLN1 PPIA PPID PPIL2 PPP1CC PPP1R14A PPP1R17 PPP1R32 PPP1R3C PPP1R8 PPP2R4 PPP2R5C PPP2R5E PPP3CC PPP5C PPP6R2 PQBP1 PRAM1 PRDX2 PRDX5 PRICKLE2 PRKAB1 PRKCD PRKCG PRKCI PRKRIP1 PROSER2 PRPF38A PRPF4 PRPSAP2 PRR14 PRR15 PRR16 PRRC1 PRRC2B PRSS2 PRSS23 PRSS3 PRSS33 PSAT1 PSEN1 PSEN2 PSMA1 PSMA5 PSMA7 PSMB4 PSMC1 PSMD11 PSMD4 PSMD5 PSME1 PSME2 PSRC1 PTBP1 PTBP3 PTGDR PTGIS PTK2 PTK6 PTMS PTP4A1 PTPN12 PTPN7 PTPRO PTTG2 PUS7L PUSL1 PWP1 PYCR2 PYROXD1 QARS QKI QPCTL R3HDML RAB10 RAB11B RAB14 RAB1B RAB26 RAB27A RAB28 RAB2B RAB35 RAB38 RAB39A RAB3A RAB3D RAB40B RAB43 RAB5C RAB7B RAB8B RABL3 RAD51AP1 RAD51C RAI2 RALGPS1 RAP1B RAPGEFL1 RASA1 RASA3 RASGRP2 RASGRP3 RASL10B RASL11B RASL12 RASSF3 RASSF8 RBCK1 RBM39 RBM42 RBM4B RBM8A RBPJ RBPJL RBX1 RCAN1 RCBTB1 RCOR3 RD3 REG1A RETSAT RFWD3 RGL1 RGS1 RGS10 RGS14 RGS18 RGS3 RGS5 RIMS4 RING1 RIOK1 RIOK2 RIT2 RITA1 RLBP1 RMND5A RNASE11 RNF11 RNF115 RNF138 RNF151 RNF183 RNF185 RNF32 RNF34 RNF41 RNMTL1 RNPC3 ROPN1L ROR1 RP9 RPA2 RPA4 RPAP3 RPF2 RPL12 RPL23 RPL30 RPL31 RPL34 RPL36 RPL37 RPL37A RPL3L RPL41 RPS10 RPS11 RPS12 RPS14 RPS16 RPS18 RPS19 RPS20 RPS21 RPS25 RPS26 RPS27A RPS6KA5 RPS6KA6 RPS6KB1 RPS9 RPUSD2 RRAGB RRP15 RSPH10B2 RSPH3 RSRC2 RSRP1 RSU1 RTF1 RTKN RUFY3 RUSC1 RUVBL2 RWDD2B RXFP3 S100A16 S100A8 SAE1 SAMHD1 SAR1A SART1 SASH3 SCAMP3 SCAND2P SCD SCEL SCO2 SCYL1 SDC1 SDCCAG3 SDF4 SEC24C SECISBP2 SENP1 SENP2 SEPT1 SEPT12 SEPT5 SEPT9 SERAC1 SERBP1 SERF1A SERP1 SERPINA3 SERPINB2 SERPIND1 SERTM1 SET SETBP1 SETD3 SF3A3 SF3B2 SF3B6 SGCG SGK2 SGK3 SH2D1B SH3BGRL3 SH3BP5 SH3GL2 SH3GLB1 SH3RF2 SHC1 SHC3 SHMT2 SHOC2 SIGIRR SIK2 SIRT5 SIRT7 SIVA1 SIX2 SKA3 SKAP1 SKAP2 SLAIN2 SLC17A5 SLC1A1 SLC22A6 SLC2A2 SLC35B1 SLC38A2 SLC41A3 SLC48A1 SLC4A1AP SLC7A1 SLCO2B1 SLFNL1 SLIT1-AS1 SLX4 SMAD1 SMAD3 SMAP1 SMARCB1 SMG5 SMIM11 SMTNL2 SMURF1 SMYD3 SNAI2 SNAP25 SNCA SNCB SND1 SNRNP35 SNRNP40 SNRNP70 SNURF SNX1 SNX17 SNX21 SNX27 SOCS3 SOCS5 SOD2 SOX5 SOX7 SP140L SP2 SPAG6 SPANXN3 SPATA2 SPATA4 SPATA7 SPATS2 SPC24 SPEG SPG20 SPIC SPINK6 SPINT2 SPON1 SPRR4 SPSB2 SPX SPZ1 SRPK1 SRPK2 SRR SRRM2 SRRT SRSF1 SRSF3 SRSF6 SRSF8 SRSF9 SSB SSBP3 SSH3 SSTR2 ST3GAL6 STAC STARD10 STAT5B STAU1 STIP1 STK11 STK17B STK25 STK26 STK33 STK40 STOML1 STOML2 STOML3 STRIP2 STX11 STXBP1 SUB1 SULF1 SULT1A3 SUMO1 SUN5 SUPT4H1 SURF2 SUSD3 SYCP2L SYF2 SYK SYNCRIP SYNJ2BP SYT17 SYT6 SYVN1 TAB2 TACO1 TAF11 TAF1B TAF6 TAF7L TAF9 TAF9B TAGLN2 TANK TAP2 TARBP2 TARDBP TARP TASP1 TBC1D10C TBC1D20 TBC1D21 TBC1D3P2 TBC1D7 TBC1D9B TBCC TBCD TBCK TBK1 TBPL1 TBX22 TCEA1 TCEA2 TCEAL2 TCEAL8 TCEANC TCEANC2 TCF19 TCL1B TCN2 TCP10 TCP10L TCP11 TCP11L1 TCP11L2 TEK TET3 TEX2 TEX37 TFPI TFPT TGFB1 TGFB2 TGFBR2 TGIF1 TGM2 THAP3 THAP4 THAP7 TICRR TIGD1 TIMM17B TIMMDC1 TIPIN TIPRL TIRAP TK1 TLE3 TLL1 TM2D1 TMA16 TMA7 TMCC2 TMEM126B TMEM175 TMEM180 TMEM183A TMEM255A TMEM261 TMEM35 TMEM53 TMEM97 TMOD2 TMOD4 TMUB1 TMX3 TNFAIP8L1 TNFRSF14 TNFSF13B TNFSF14 TNIP2 TNNT2 TOB1 TOM1 TOM1L2 TOMM5 TOP1 TOX2 TP53BP2 TP53TG1 TP53TG5 TPD52L2 TPD52L3 TPH1 TPI1 TPMT TPPP TPRA1 TPRXL TPT1 TRAF3IP1 TRAF6 TRAIP TRAM1 TRAP1 TRAPPC2L TRAPPC3 TRAPPC4 TRDMT1 TRIB2 TRIB3 TRIM16 TRIM39 TRIM40 TRIM41 TRIM44 TRIM47 TRIM52 TRIM63 TRIM69 TRIML1 TRMT1L TRMT2A TRPT1 TRUB1 TSKS TSLP TSNAXIP1 TSPAN13 TSPAN5 TSPY2 TSPYL1 TSSC4 TSSK2 TSSK6 TTC23 TTK TTLL6 TTLL7 TTPA TUBB TWF1 TXNDC5 UBAC1 UBB UBE2DNL UBE2E2 UBE2G1 UBE2M UBE2S UBE3A UBE3C UBL3 UBL4A UBQLN1 UBXN10 UBXN6 UBXN7 UCHL5 UGCG UGGT2 UGT1A10 ULK4 UNG UPF3A URI1 USE1 USF1 USP12 USP2 USP39 USP48 USP5 USP6 USP6NL UTP23 UXT VAC14 VAMP3 VAPA VASH2 VAT1L VCY1B VDAC2 VHL VIM VIPR2 VPS29 VPS33B VPS35 VPS37A VPS37C VPS41 VSIG4 VTA1 VTN VWA5A WAC WARS WARS2 WASH2P WASH3P WASL WDR45 WDR45B WDR5 WDR88 WDR89 WHSC1 WIBG WNT4 WWC3 XAF1 YAE1D1 YPEL3 YTHDF2 YWHAB YWHAG YWHAZ YY1 ZADH2 ZAP70 ZC2HC1A ZC3HAV1 ZC3HAV1L ZC3HC1 ZCCHC12 ZCCHC17 ZCCHC6 ZCCHC8 ZDHHC23 ZDHHC7 ZEB2 ZFAND5 ZFC3H1 ZFP36 ZFYVE1 ZFYVE16 ZFYVE27 ZGRF1 ZHX2 ZKSCAN1 ZMAT3 ZMAT4 ZMYM3 ZMYM5 ZNF2 ZNF22 ZNF23 ZNF322 ZNF343 ZNF35 ZNF365 ZNF410 ZNF483 ZNF574 ZNF581 ZNF622 ZNF684 ZNF706 ZNF720 ZNF740 ZNF75A ZNF839 ZRSR2 ZSCAN1 ZSCAN16 ZSCAN18 ZSCAN5A ZW10 ZWINT ZXDC	91 interactors: ACTN1 AP1M2 APBA1 APH1A APH1B APOE APP BACE1 BCL2 BCL2L1 CASP1 CASP3 CASP4 CASP6 CASP7 CASP8 CDH1 CDK5 CFL1 CIB1 CTNNA1 CTNNB1 CTNND1 CTNND2 CYP2C18 CYP2C8 DLL1 DOCK3 DSP ECSIT EFHD1 EFNB2 ENSA EPB41L3 ERN1 ETFA FBXL12 FBXW7 FGF13 FLNA FLNB GAPDH GCDH GDI1 GFAP GSK3B HERPUD1 HMGB1 ICAM5 ITSN2 JUP KANK2 KCNIP3 KCNIP4 MAPT METTL2B MTCH1 NCSTN NOS3 NOTCH1 NOTCH2 NOTCH3 NOTCH4 OXCT1 PDCD4 PIK3R1 PKP4 PRAM1 PRDX2 PRKACA PRKCZ PSENEN PSMA5 PSMB1 RAB11A RAB3A RAD23A RHEB RMDN3 RNF32 SCAF11 SCN1A ST13 STAMBPL1 TCF4 TCF7L2 TDP2 TUBA1B UBQLN1 UMPS YME1L1
Entrez ID		351	5663
HPRD ID		00100	00087
Ensembl ID		ENSG00000142192	ENSG00000080815
Uniprot IDs		B4DGD0 B4DJT9 E9PEV0 E9PG40 P05067	P49768
PDB IDs		1AAP 1AMB 1AMC 1AML 1BA4 1BA6 1BJB 1BJC 1BRC 1CA0 1HZ3 1IYT 1MWP 1OWT 1QCM 1QWP 1QXC 1QYT 1TAW 1TKN 1UO7 1UO8 1UOA 1UOI 1X11 1Z0Q 1ZE7 1ZE9 1ZJD 2BEG 2BOM 2BP4 2FJZ 2FK1 2FK2 2FK3 2FKL 2FMA 2G47 2IPU 2LFM 2LLM 2LMN 2LMO 2LMP 2LMQ 2LNQ 2LOH 2LP1 2LZ3 2LZ4 2M4J 2M9R 2M9S 2OTK 2R0W 2WK3 2Y29 2Y2A 2Y3J 2Y3K 2Y3L 3AYU 3DXC 3DXD 3DXE 3GCI 3IFL 3IFN 3IFO 3IFP 3JTI 3KTM 3L33 3L81 3MOQ 3MXC 3MXY 3NYJ 3NYL 3OVJ 3OW9 3SV1 3U0T 3UMH 3UMI 3UMK 4HIX	2KR6
Enriched GO Terms of Interacting Partners?		Cellular Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Process Cellular Nitrogen Compound Metabolic Process Gene Expression Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Response To Stress Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Organelle Organization Apoptotic Process Positive Regulation Of Cellular Metabolic Process Programmed Cell Death Heterocycle Metabolic Process Cellular Localization Cellular Aromatic Compound Metabolic Process Death Biosynthetic Process Cell Death Developmental Process RNA Metabolic Process Metabolic Process Regulation Of Apoptotic Process Regulation Of Cellular Process Macromolecule Biosynthetic Process Establishment Of Localization In Cell Cellular Macromolecule Biosynthetic Process Response To Stimulus Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Mitotic Cell Cycle Intracellular Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Intracellular Transport Cell Cycle Regulation Of Catalytic Activity Viral Process Regulation Of Signal Transduction Posttranscriptional Regulation Of Gene Expression Regulation Of Signaling Cellular Protein Metabolic Process Mitotic Cell Cycle Process Negative Regulation Of Cellular Metabolic Process Cellular Response To Stress Cellular Component Assembly Regulation Of Cellular Component Organization Negative Regulation Of Protein Metabolic Process Multicellular Organismal Development	Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Cell Death Regulation Of Apoptotic Process Cell Development Notch Receptor Processing Nervous System Development Generation Of Neurons Cell Differentiation Regulation Of Signaling Positive Regulation Of Cell Death Neurogenesis Positive Regulation Of Catalytic Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death System Development Execution Phase Of Apoptosis Neuron Differentiation Anatomical Structure Development Multicellular Organismal Development Cellular Response To Stimulus Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Negative Regulation Of Cell Death Developmental Process Neuron Projection Development Negative Regulation Of Programmed Cell Death Neuron Development Signaling Response To Stimulus Regulation Of Signal Transduction Regulation Of Neurogenesis Regulation Of Cell Differentiation Cell Communication Regulation Of Protein Localization Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Response To Stress Regulation Of Establishment Of Protein Localization Notch Signaling Pathway Positive Regulation Of Proteolysis Negative Regulation Of Apoptotic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Cell Development Cell Projection Organization Negative Regulation Of Cell Differentiation Positive Regulation Of Signal Transduction Cell Morphogenesis Involved In Differentiation Regulation Of Cellular Localization
Tagcloud ?		amino analogues aptp clonal cytotoxic cytotoxicity derivatives equaled formazan humans incubation induces ion methyl methylisoquinolines monoamine mpp mptp oxidase oxidation oxidized parkinsonism pc12 phenyl phenylpyridinium pheochromocytoma synthesized tetrahydropyridine tetrazolium	1795g 2125g abeta37 abeta39 abeta40 advance dementia dementias doi e599k ejhg fus g709s genetics genotyping granulin grn harbored hek293 journal lewy mapt neuropathological pd publically publication shifted tar variants
Tagcloud (Difference) ?		amino analogues aptp clonal cytotoxic cytotoxicity derivatives equaled formazan humans incubation induces ion methyl methylisoquinolines monoamine mpp mptp oxidase oxidation oxidized parkinsonism pc12 phenyl phenylpyridinium pheochromocytoma synthesized tetrahydropyridine tetrazolium	1795g 2125g abeta37 abeta39 abeta40 advance dementia dementias doi e599k ejhg fus g709s genetics genotyping granulin grn harbored hek293 journal lewy mapt neuropathological pd publically publication shifted tar variants
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