ADAM12 and TFAP2D

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ADAM12	TFAP2D
Description		ADAM metallopeptidase domain 12	transcription factor AP-2 delta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Plasma Membrane Membrane	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity SH3 Domain Binding Metal Ion Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Proteolysis Cell Adhesion Myoblast Fusion Positive Regulation Of Angiogenesis	Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Regulation Of Cell Population Proliferation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Inferior Colliculus Development
Pathways		Signaling by EGFR Invadopodia formation	Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Activation of the TFAP2 (AP-2) family of transcription factors
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Blood protein levels ( 30072576) Endometrial cancer ( 24096698) Extremely high intelligence ( 29731509) Heel bone mineral density ( 30598549) Intraocular pressure ( 30054594) Itch intensity from mosquito bite ( 28199695) Loneliness ( 27629369) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Mild influenza (H1N1) infection ( 26379185) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 27021288 26184070) Placental abruption ( 29884306) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Visceral fat ( 22589738)	Age at first sexual intercourse ( 34211149) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body mass index ( 29273807) Breast size ( 22747683) Endometriosis or endometrial cancer (pleiotropy) ( 29608257) Fruit consumption ( 32066663) Hand grip strength ( 29691431) Overweight status ( 25133637) Parahippocampal gyrus volume ( 31530798) Refractive error ( 32231278) Response to citalopram or escitalopram in depression ( 27622933) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Subcutaneous adipose tissue ( 29178545) Systolic blood pressure ( 28135244) Western dietary pattern ( 28644415)
Interacting Genes		40 interacting genes: ACTN2 ADAMTSL4 CYSRT1 EGF ESM1 FHL5 FSTL3 GRB2 GUCD1 HOXA1 IGFBP3 IGFBP5 KRT83 KRTAP1-1 KRTAP1-3 KRTAP10-8 KRTAP12-2 KRTAP3-1 KRTAP3-2 KRTAP4-12 KRTAP5-6 KRTAP5-9 KRTAP6-2 KRTAP9-2 KRTAP9-8 LCE5A MAPKBP1 NBPF19 NOTCH2NLA OTX1 PACSIN3 PIK3R1 RECK SH3D19 SLC15A2 SPRY1 SPRY4 SRC TFAP2D YES1	64 interacting genes: ADAM12 ADAMTSL4 AGR2 AKAP8L BAG4 CAMK2A CARD10 CDPF1 CEP76 CIMIP2B CNFN CSNK2B CYSRT1 FAM168A GUCD1 GYS1 HOXD12 IKZF3 INCA1 KLHL20 KPRP KRT31 KRT34 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP11-1 KRTAP12-3 KRTAP15-1 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP2-3 KRTAP2-4 KRTAP26-1 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP9-2 KRTAP9-3 MLH1 OIP5 PITX1 PLEKHG4 PRR22 PSMB4 RAD54L2 SIVA1 SLAIN1 SPMIP9 SPRY1 SSC4D TEPSIN TLE5 TNS2 TRAF1 TRIM42 TSC1 USP54 VPS37C ZBTB32 ZMYND12
Entrez ID		8038	83741
HPRD ID		04092	11627
Ensembl ID		ENSG00000148848	ENSG00000008197
Uniprot IDs		A8K6G4 O43184 Q5JRP2	Q7Z6R9
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Insulin-like Growth Factor Binding Protein Complex Insulin-like Growth Factor Ternary Complex Developmental Process Fibronectin Binding Insulin-like Growth Factor Receptor Signaling Pathway Neurotrophin TRKA Receptor Binding Phosphotyrosine Residue Binding T Cell Costimulation Insulin-like Growth Factor II Binding Protein Binding Cytosol Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Substrate Binding Insulin-like Growth Factor Binding Insulin-like Growth Factor I Binding Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Epidermis Development Hair Cycle Negative Regulation Of Cell-substrate Adhesion Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Keratinization Positive Regulation Of Membrane Protein Ectodomain Proteolysis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ERBB Signaling Pathway Type B Pancreatic Cell Proliferation Regulation Of MAPK Cascade Angiotensin-activated Signaling Pathway Actin Filament Cellular Response To Platelet-derived Growth Factor Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway	Intermediate Filament Keratin Filament Protein Binding Keratinization Identical Protein Binding
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